Publications by authors named "Ichiro Oda"
Objective To evaluate the influence of sample collection time during esophagogastroduodenoscopy (EGD) on the accuracy of a newly approved point-of-care test (POCT)-based polymerase chain reaction kit for detecting Helicobacter pylori and clarithromycin susceptibility in gastric wash fluid. Methods Intragastric fluid was collected at three time points: Collection Time 1 (start of EGD), Collection Time 2 (during EGD), and Collection Time 3 (after indigo carmine spraying). POCT-based quantitative PCR (qPCR) targeting 23S rRNA domain V (2142/2143) was used to quantify H.
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- Measuring the size of lesions in the gastrointestinal tract is challenging due to the fisheye lens used in endoscopy, which can distort visual data.
- To address this, a new phase-shift method was developed for accurately measuring 3D shapes on curved surfaces during endoscopic examinations.
- Testing showed that the new system's measurements had a height difference of only 0.24 mm compared to standard methods, with a path length error of less than 1% for lesions, indicating improved accuracy in assessing lesion sizes.
Background And Aim: Perforation is one of the most important complications of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Several studies have examined risk factors for intraoperative and delayed perforations, but most were retrospective analyses with small numbers of patients.
Methods: This study represents a secondary analysis of a Japanese multicenter prospective cohort study.
Article Synopsis
- This study investigates long-term surveillance for gastric cancer, particularly focusing on cases diagnosed 10 or more years after initial treatment.
- It analyzes 377 patients across 14 institutions, revealing that invasive cancers diagnosed after 10 years tend to be more aggressive and have a higher pathological stage compared to those diagnosed sooner.
- The findings emphasize the importance of ongoing surveillance for all patients, regardless of mucosal atrophy, especially after 10 years post-eradication.
Article Synopsis
- A study was conducted to evaluate the effectiveness of endoscopic resection (ER) for elderly patients (≥75 years) with early gastric cancer (EGC), as previous evidence was limited.
- The analysis involved 3,371 patients with 3,821 EGCs, highlighting key outcomes such as high rates of successful resections and low rates of complications, particularly for lesions within the established treatment guidelines.
- The findings suggest that lesions of ≤3 cm and those classified as elderly-low have the potential to be new indicators for ER suitability, demonstrating favorable curative outcomes for elderly patients.
Article Synopsis
- - Messenger RNA (mRNA) vaccines, like the one used for COVID-19, effectively help the immune system, but the specifics of how they work and why responses vary among individuals remain unclear.
- - Researchers studied gene expression changes in 200 vaccinated healthcare workers by analyzing blood samples taken before and after vaccination at multiple time points, using advanced techniques like UMAP for data visualization.
- - The study identified different groups based on gene expression patterns over time and demonstrated that high-throughput transcriptome analysis is valuable for conducting large-scale clinical research efficiently.
Background: Several studies have reported the metachronous gastric cancers (MGCs) with possible lymph node metastasis (LNM) after endoscopic submucosal dissection (ESD) and Helicobacter pylori (H. pylori) eradication in which a curative ESD had not been achieved. There have been no published reports of evaluations of the features of patients with MGC with possible LNM after ESD and H.
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- A follow-up survey conducted in 2022 assessed radiation protection practices among medical staff in endoscopy-fluoroscopy departments in Japan, following a 2020 study that reported low protective equipment usage and insufficient knowledge.
- The survey included 464 participants, with high lead apron usage (98%) but much lower rates for other gear like thyroid collars (27%) and lead glasses (35%), indicating limited improvement since the 2020 survey.
- While many staff attended radiation protection lectures (76%) and were aware of key concepts such as cancer risk related to radiation exposure, knowledge about specific dosage limits and diagnostic reference levels remained low, signaling further educational needs.
Article Synopsis
- This study focused on understanding the clinical outcomes and management of adverse events (AEs) in patients who had endoscopic resection (ER) for superficial duodenal epithelial tumors (SDETs).
- Researchers examined data from patients treated between January 2008 and July 2018 across 18 Japanese hospitals, specifically looking at the occurrence and management of AEs and the risks associated with surgical conversion.
- Findings showed an 8% surgical conversion rate among patients with AEs, with higher rates linked to delayed perforations and involvement of the major papilla, highlighting the need for preventive measures against delayed perforations in the first three days post-surgery.
Article Synopsis
- The study examined endoscopic resection outcomes for duodenal tumors, focusing on the occurrence of synchronous (present at the same time) and metachronous (developing later) lesions, and their links to colorectal advanced adenoma (CAA) and colorectal cancer (CRC).
- A total of 2,658 patients were analyzed, revealing that 7.0% had synchronous lesions and 2.0% had metachronous lesions, with a 5-year incidence rate of 4.1% for metachronous lesions.
- While the incidence of CAA was higher in patients with synchronous lesions (11.8% vs 7.5%), and CRC was more common in metachronous
Background: The clinicopathological features and the distribution of lymph node metastasis in patients with T1a-MM and T1b-SM1 superficial esophageal squamous cell carcinoma remain unclear; therefore, the optimal treatment strategy is still controversial.
Methods: One hundred and ninety-one patients who had undergone a thoracic esophagectomy with 3-field lymphadenectomy and who were pathologically confirmed to have thoracic superficial esophageal squamous cell carcinoma that had reached the T1a-MM or T1b-SM1 stage were retrospectively reviewed. Risk factors of lymph node metastasis, the distribution of lymph node metastasis, and long-term outcomes were evaluated.
Objectives: The multi-institutional, single-arm, confirmatory trial JCOG0607 showed excellent efficacy of endoscopic submucosal dissection (ESD) for the expanded indication of intramucosal intestinal-type early gastric cancer (EGC), which consists of two groups: lesions >2 cm if clinical finding of ulcer (cUL)-negative, or those ≤3 cm if cUL-positive because of the expected low risk of lymph node metastasis. However, the proportion of noncurative resections (NCR) requiring additional surgery was high (32.4%).
View Article and Find Full Text PDFOur study aimed to compare the treatment outcomes between endoscopic submucosal dissection (ESD) with an insulated-tip knife (ESD-IT) and a needle-type knife (ESD-N) for large superficial esophageal neoplasms, as no study of this kind has been previously reported. We used the dataset of a multicenter, randomized controlled trial that compared conventional ESD (C-ESD) and traction-assisted ESD (TA-ESD) for superficial esophageal neoplasms. We compared the procedural outcomes between ESD-IT and ESD-N in a post hoc analysis and conducted sub-analyses based on traction assistance and electrical knife type.
View Article and Find Full Text PDFBackground & Aims: We aimed to clarify the long-term outcomes of endoscopic resection (ER) for early gastric cancers (EGCs) based on pathological curability in a multicenter prospective cohort study.
Methods: We analyzed the long-term outcomes of 9054 patients with 10,021 EGCs undergoing ER between July 2010 and June 2012. Primary endpoint was the 5-year overall survival (OS).
Introduction: Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic even after vaccination. We aimed to identify immunological heterogeneity over time in vaccinated healthcare workers using neutralization antibodies and neutralizing activity tests.
Methods: Serum samples were collected from 214 healthcare workers before vaccination (pre) and on days 22, 90, and 180 after receiving the first dose of BNT162b2 vaccine (day 0).
Objective: There are little data regarding the efficacy of texture and color enhancement imaging (TXI) for early gastric cancer (EGC) diagnosis. This study aimed to compare the color difference and visibility of EGC between white light imaging (WLI) and TXI.
Methods: This study included 20 EGCs of 18 patients undergoing endoscopic submucosal dissection.
Endoscopic resection (ER) is an alternate minimally invasive treatment for superficial esophageal squamous cell carcinoma (SESCC). We aimed to review the clinical indications and treatment outcomes of ER for SESCC. Endoscopic mucosal resection is relatively easy and efficient for SESCC ≤ 15 mm.
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- * A questionnaire survey conducted with 282 participants revealed that while most staff wore lead aprons, very few used other protective gear like thyroid collars (32%) and lead glasses (21%), and only 69% wore radiation dosimeters.
- * The findings suggest that knowledge about radiation exposure correlates with better adherence to protective measures, emphasizing the need for improved education and training on radiation safety for medical professionals.
Article Synopsis
- Management of elderly patients with early gastric cancer is crucial in aging societies like Japan, where endoscopic resection is preferred for cancers with minimal lymph node metastasis risk (<1%).
- Endoscopic submucosal dissection is the recommended procedure due to its effective 'en bloc' resection and favorable short-term outcomes, while considerations for patients' physical and nutritional states are increasingly important.
- Data shows lower 5-year survival and significant post-operative mortality in older patients, prompting the need for less invasive treatment options and the development of tools to better assess lymph node metastasis risk.
Background And Aims: Multiple developments of squamous dysplasia and squamous cell carcinoma (SCC) in the upper aerodigestive tract have been explained by field cancerization phenomenon and were associated with alcohol and cigarette use. Second primary SCC development after curative treatment impairs patients' quality of life and survival; however, how these consumption and cessation affect field cancerization is still unknown.
Methods: This is a multicenter cohort study including 331 patients with superficial esophageal SCC (ESCC) treated endoscopically and pooled data from 1022 healthy subjects for comparison.
Background: The heterotopic submucosal gland (HSG) is a common incidental finding in gastrectomy specimens. The majority of HSGs are small incidental lesions, which are also known as gastritis cystica profunda. However, larger lesions may appear as an inverted growth of well-organized mucosa referred to as gastric inverted polyps.
View Article and Find Full Text PDFBackground And Aims: Endoscopic resection (ER) for early gastric cancer (EGC) can preserve the stomach; however, the remaining stomach can develop second gastric cancer. Few reports have prospectively investigated the incidence and treatment outcomes of second gastric cancer.
Methods: This post-hoc analysis used the dataset of the single-arm confirmatory trial, JCOG0607.