Publications by authors named "Ichiro Nakahara"

Purpose: The safety and efficacy of Woven EndoBridge (WEB) treatment has been proven. However, only a few standard techniques for safe and versatile WEB deployment have been described in the literature. In this study, we introduce the "make a flower bud and push at neck" technique to achieve safety and versatility during WEB treatment, referred to simply as the "flower bud" technique.

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Background: Dislocation is a major complication of total hip arthroplasty (THA). This study aimed to assess the dislocation rate after THA using the combined strategy of using CT-based navigation, large diameter heads, and posterior soft tissue repair in a large cohort.

Methods: We included 1410 patients who had undergone primary cementless THA using the CT-based navigation system.

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Background: We aimed to quantify the incidence of atrial fibrillation (AF) in patients with cryptogenic stroke globally, as well as separately in patients in and outside of Japan, using an implantable loop recorder from a prospective, observational, Reveal LINQ Registry.

Methods And Results: Patients developing cryptogenic stroke and monitored by implantable loop recorder for searching AF were studied. The primary end point was incidence of AF within 36 months after insertion.

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  • The study aimed to classify medullary bridging vein-draining dural arteriovenous fistulas (MBV-DAVFs) near the foramen magnum and analyze their structure and treatment outcomes.
  • It categorized these fistulas into four groups: JV-BV (jugular vein proximity), ACV-BV (anterior condylar vein), MS-BV (marginal sinus), and SCS-BV (suboccipital cavernous sinus), and observed a male predominance among patients.
  • Results showed varying treatment success rates with transarterial embolization (TAE) - complete obliteration was highest in the JV-BV group and lowest in the SCS-BV group, highlighting treatment challenges
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Objective: LEONIS Mova (SB-KAWASUMI LABORATORIES, Kanagawa, Japan, hereinafter called LEONIS Mova) is a steerable microcatheter (MC) that enables angle adjustment of the catheter tip using a hand-operated dial. LEONIS Mova may be useful for flow diverter placement when access to the distal parent artery with a conventional MC and microguidewire (MGW) is considered difficult or impossible. Here, we report three such cases encountered during flow diverter placement in large and giant internal carotid artery aneurysms.

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It is impossible to predict underlying anomalies in acute large vessel occlusion and it could be a problem when performing mechanical thrombectomy (MT). We report a case of MT for occlusion of the fenestrated middle cerebral artery (MCA) M1 segment. A 49-year-old woman presented to our hospital with dysarthria and left hemiparesis.

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  • The study aimed to compare clinical outcomes between endovascular coiling (EC) and surgical clipping (SC) for patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH), due to ongoing debates about which procedure is more effective.
  • Using data from a specific study, the researchers matched patients based on their characteristics to analyze outcomes and in-hospital mortality, focusing on those graded III-V on the World Federation of Neurological Societies (WFNS) scale.
  • Results showed that EC was associated with significantly better clinical outcomes compared to SC, although there was no significant difference in in-hospital mortality between the two methods; several risk factors for poor outcomes were identified for both procedures.
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Ischemia-induced postoperative scalp necrosis in the superficial temporal artery (STA) region is known to occur after STA-middle cerebral artery anastomoses. However, no reports have evaluated the risk of postoperative scalp necrosis in the occipital artery (OA) region. This study examined the surgical procedures that pose a risk for postoperative scalp necrosis in the OA region following posterior cranial fossa surgery.

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Purpose: Prasugrel is not approved for patients treated with flow diverters, which have a high metal coverage ratio. However, robust antiplatelet therapy with prasugrel may prevent thromboembolic complications. We administered prasugrel and aspirin to all patients treated with flow diverters and reported the safety of the antiplatelet therapy regimen.

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  • A new hip stem made of carbon fiber-reinforced polyetheretherketone (CFR/PEEK) is being developed to help treat periprosthetic joint infections (PJIs) through an antibiotic release mechanism.
  • In an experimental study with sheep, researchers tested how well the antibiotic vancomycin eluted from the implants and assessed their effectiveness in treating induced PJIs caused by Staphylococcus aureus.
  • Results showed that the implant released about 70% of vancomycin over 21 days, and all successfully infected joints exhibited negative cultures and no signs of infection three weeks after surgery, demonstrating the efficacy of the therapeutic stem.
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Objective: This retrospective study aimed to investigate factors associated with inhibition of early aneurysm obliteration after flow diverter (FD) treatment. We also created the early obliteration inhibition (EOI) score for pre-operative evaluation.

Methods: We examined 110 cerebral aneurysms in 104 patients who underwent FD treatment.

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Background And Purpose: There has been limited literature regarding the bridging veins (BVs) of the medulla oblongata around the foramen magnum (FM). The present study aims to analyze the normal angioarchitecture of the BVs around the FM using slab MIP images of three-dimensional (3D) angiography.

Methods: We collected 3D angiography data of posterior fossa veins and analyzed the BVs around the FM using slab MIP images.

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Objective: The Woven EndoBridge (WEB) was developed to treat wide-neck bifurcation intracranial aneurysms. Occasionally, persistent contrast-filling has been observed in the WEB after treatment. The purpose of our study was to investigate its incidence, predictive factors, and clinical impact.

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Purpose: Optimal size selection is important for successful Woven EndoBridge (WEB) treatment. Conventional recommendations for WEB sizing based on aneurysm width and height sometimes require device exchange. We aimed to design a novel volume-based parameter, the ideal WEB-aneurysm volume (iWAVe) ratio, for optimal WEB sizing.

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  • Periprosthetic joint infection (PJI) can occur after total hip replacement, leading to severe complications, prompting the development of a new drug-loaded carbon fiber-reinforced polymer (CFRP) prosthesis that allows for one-stage surgery.
  • The study aimed to analyze how vancomycin, an antibiotic, diffuses from CFRP implants by modifying the mixing ratio of vancomycin paste and the size of holes in the implants.
  • Results showed the best diffusion occurred with a 1:1.4 mixing ratio of vancomycin paste and a 2 mm hole diameter, both in laboratory tests and in a rabbit model, indicating drug release can be optimized by adjusting these parameters.
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Objective: Although a qualitative diagnosis of plaque causing carotid stenosis has been attempted with carotid computed tomography angiography (CaCTA), no clear findings have been reported. We examined the correlation between the plaque CT values and plaque images obtained by magnetic resonance imaging to derive a qualitative diagnosis of the plaque using CaCTA.

Methods: Preoperative CaCTA images acquired from patients stented for carotid stenosis were retrospectively analyzed with respect to magnetization-prepared rapid acquisition with gradient echo and time-of-flight magnetic resonance angiography data.

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Objective: Some aneurysmal subarachnoid hemorrhage (SAH) patients are delayed in their presentation. This can cause a washout of the subarachnoid hematoma and a potential misdiagnosis. As a result, they may suffer rerupture of the aneurysm and preventable deterioration.

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Objectives: This study aimed to determine the impact of the approval of prothrombin complex concentrates on the treatment of vitamin K antagonist-related intracerebral hemorrhage.

Materials And Methods: We retrospectively studied all patients with vitamin K antagonist-related intracerebral hemorrhage treated with prothrombin complex concentrate at our institutes between January 2010 and June 2021. Before approval, prothrombin complex concentrate was administered as either 500 or 1000 IU at the physician's discretion (previous dose group).

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The posterior condylar vein is an emissary vein that connects the extracranial and intracranial venous systems through the posterior condylar canal (PCC). Dural arteriovenous fistulas (DAVF) of the PCC are rare, and only seven cases have been reported. Transvenous embolization (TVE) is the first-line treatment for PCC DAVF and is predominantly performed through the internal jugular vein.

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Objectives: The benefit of mechanical thrombectomy for acute ischemic stroke is highly time dependent. However, time to treatment is longer for in-hospital stroke patients than community-onset stroke patients. This study aimed to clarify the cause of this difference.

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Background: Cerebral amyloid angiopathy-related inflammation (CAA-I) presents with slowly progressive nonspecific neurological symptoms, such as headache, cognitive function disorder, and seizures. Pathologically, the deposition of amyloid-β proteins at the cortical vascular wall is a characteristic and definitive finding. Differential diagnoses include infectious encephalitis, neurosarcoidosis, primary central nervous system lymphoma, and glioma.

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  • The study compares two methods of measuring cerebral blood flow (CBF) in patients with cerebrovascular disease: Bayesian estimation with advanced noise reduction (BEANR) and reformulated singular value decomposition (rSVD), using single-photon emission computed tomography (SPECT) as the reference standard.
  • Results showed that BEANR's CBF measurements had a significant positive correlation with SPECT, while rSVD did not correlate well with SPECT, indicating BEANR's reliability.
  • The analysis revealed that BEANR had smaller limits of agreement than rSVD and a significantly different mean difference in CBF indices compared to SPECT, suggesting BEANR is more effective for C
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Artificial joints are exposed to loads on a daily basis. Loads on the bone through the artificial joint and the joint's sliding surface shear force may cause implant fixation failure, fatigue fractures, wear of the bearing and foreign body reactions. Artificial joints can experience sudden internal damage, which can be fatal if it occurs during activities performed at high altitudes or in water.

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This study used a rabbit model to investigate the osteocompatibility of SiN-coated carbon fiber-reinforced polyetheretherketone (CFRP) and hydroxyapatite (HA)-coated CFRP with antibiotics (vancomycin [VCM]) and antithrombotic drugs (polyvinylpyrrolidone [PVP]). HA-coated cylindrical CFRP implants were used as the controls (HA), and HA-coated implants treated with VCM and PVP were prepared (HA-VP) as the test groups; a cylindrical CFRP coated with SiN was also prepared (SiN). Ten implants from each group were randomly inserted into the femoral diaphysis of rabbits.

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We report a case of vertebral artery dissecting aneurysm (VADA) that developed with subarachnoid hemorrhage and was found to be occluded based on subsequent digital subtraction angiography. Few reports have been published on ruptured VADA in which ipsilateral vertebral arteries are occluded. The proper management of this type of aneurysm is controversial.

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