Publications by authors named "Ichiro Hamanaka"
Article Synopsis
- Primary Percutaneous Coronary Intervention (PCI) has become the standard treatment for ST-segment elevation myocardial infarction (STEMI) in Japan, effectively reducing mortality rates, even for patients in cardiogenic shock.
- Key guideline updates include recommending radial access and drug-eluting stents (DES) over bare-metal stents (BMS) for STEMI patients, and endorsing complete revascularization before discharge as a Class IIa recommendation.
- For Non-ST-Elevation Myocardial Infarction (NSTEMI) patients, early invasive strategies and complete revascularization without cardiogenic shock are now highlighted, along with changes in antithrombotic therapy for patients with atrial fibrillation, leading to
Objectives: We analyzed the effect of high flow-volume intermittent hemodiafiltration (HF-IHDF) on patients with advanced chronic kidney disease (CKD) undergoing procedures requiring administration of contrast medium.
Background: There is no effective method for preventing contrast-induced nephropathy (CIN), especially in patients with advanced CKD. We established HF-IHDF as a renal protective therapy with a filtration flow rate up to 5 times greater than standard continuous HDF.
The impact of the fractional flow reserve (FFR) on clinical decision-making remains unclear in daily practice. The CVIT-DEFER registry is a prospective multicenter registry enrolling consecutive patients with angiographically intermediate coronary stenosis for whom FFR measurement is clinically indicated. The treatment strategy determined from angiographic findings alone and the strategy selected after FFR measurement were compared.
View Article and Find Full Text PDFThe fractional flow reserve (FFR) is considered to be a reliable index for the assessment of clinically relevant coronary artery stenosis. However, mismatch in assessing the severity of coronary stenosis between coronary angiography and the FFR has been pointed out. The cardiovascular intervention therapeutics (CVIT)-DEFER registry is a prospective multicenter registry study that has enrolled 3,228 consecutive patients among 3,804 patients with angiographically moderate coronary artery lesions in whom FFR analysis was clinically indicated.
View Article and Find Full Text PDFAntiplatelet therapy could prevent stent thrombosis, but may be associated with an increased risk of bleeding. Recent studies have revealed that bleeding complications are relatively frequent in patients with acute coronary syndromes. Our aim was to describe the current status of antiplatelet therapy for Japanese patients with acute myocardial infarction (AMI).
View Article and Find Full Text PDFThe door-to-balloon time and total ischemic time are important predictors of the outcome in patients with ST elevation myocardial infarction (STEMI) receiving primary angioplasty, but the current situation in Japan is unknown. The Japan Acute Myocardial Infarction registry is a prospective observational study of 2,030 consecutive STEMI patients admitted to 213 Japanese institutions. The time from symptom onset to hospital arrival, door-to-balloon time, and in-hospital outcome were assessed.
View Article and Find Full Text PDFWe previously reported that continuous intravenous (IV) administration of nicorandil (NIC) inhibits QT dispersion (QTd). However, no prior study has evaluated the efficacy of NIC when administered orally to acute myocardial infarction (AMI) patients following continuous IV administration. Thirty patients with anteroseptal infarction in whom revascularization was performed successfully within 6 hours of AMI onset were included in the study and assigned to one of 3 groups: group A (continuous IV administration of NIC), group B (continuous IV and oral administration of NIC), and group C (no treatment with NIC).
View Article and Find Full Text PDFArticle Synopsis
- SOCS1 is a regulator of cytokine signaling that is activated by cardiotrophin-1 (CT-1) in the heart, and its expression may play a role in protecting the heart from inflammation-related damage during sepsis.!* -
- In a rat model, LPS exposure led to decreased heart function and increased inflammatory markers, but administering CT-1 before LPS helped prevent these negative effects.!* -
- The study suggests that boosting SOCS1 expression in heart cells could be a potential strategy to combat sepsis-induced heart issues by lowering the production of harmful inflammatory proteins.!*
Article Synopsis
- * In studies with GC-A knockout mice, males displayed more significant cardiac hypertrophy and fibrosis than females, but this was not observed in wild-type mice; treatments like castration reduced these effects in males.
- * The findings suggest that androgens play a role in gender differences in cardiac conditions through mechanisms involving AT1A receptors and GC-A, as treatments had no impact on cardiac conditions in double-knockout mice lacking both genes.
Objective: Brain natriuretic peptide (BNP) is a cardiac hormone mainly synthesized in ventricles and its expression is markedly increased in ventricular hypertrophy that involves the accumulation of extracellular matrix proteins, such as fibronectin (Fn). We recently reported that Fn signaling stimulated BNP secretion accompanied by hypertrophic responses in vitro.
Methods: To elucidate the regulatory mechanism for BNP gene transcription, we examined cis-acting elements downstream of Fn signaling in rat ventricular myocytes transfected with either the -1812 human BNP-luciferase reporter gene (-1812hBNP/Luc) or one of several truncated forms.