Antiplasmodial and interferon-gamma-modulating activities of the aqueous extract of stone breaker (Phyllanthus niruri Linn.) in malaria infection.

Plasmodium falciparum parasites are the primary cause of malaria across Africa. The problem of drug resistance to malaria is ever growing and novel therapeutic strategies need to be developed, particularly those targeting the parasite and also the host or host-pathogen interaction. Previous studies have shown that the development of cerebral malaria (CM) is related to dysregulation of the immune system in a murine malaria model of experimental cerebral malaria.

Upregulation of PCSK9, rho kinase and cardiac troponin by leaf extract improves fructose-streptozotocin-induced diabetic cardiac dysfunction in rats.

Context: The effect of in diabetic cardiac dysfunction and the possible mechanisms involved have not been explored.

Objective: To evaluate the effect of ethanol leaf extract of (NEE) on the cardiac function of fructose/streptozotocin-induced diabetic rats.

Materials And Methods: Type-2 diabetes was induced in rats with 10% fructose feeding for 14 days and an intraperitoneal administration of 40 mg/kg streptozotocin.

Abortifacient efficacy of aqueous-acetone extracts of Benth seed in female albino rats.

The present study evaluated the abortifacient potential of aqueous-acetone extract of Benth Seed on the reproductive health of matured female albino rats by monitoring the indices of dysfunctions in reproductive system. Prior to the conduction of the fertility studies, the oral acute toxicity of the seed extract was evaluated for autonomic, behavioral and neurological changes, within 24 h to determine the LD.The influence of aqueous-acetone extract of Benth Seed was evaluated for antioxidant, reproductive hormones and histology of uteri tissues primarily to monitor effects in female fertility.

Quail (Coturnix japonica) egg yolk bioactive components attenuate streptozotocin-induced testicular damage and oxidative stress in diabetic rats.

Introduction: The testicular milieu is the machinery for the metabolism of testosterone in the male reproductive system.

Purpose: The dysfunction of this highly regenerating system is inevitable in the condition of glucose imbalance as a result of insulin machinery impairment. Therefore, it is imperative to recommend dietary intervention for attenuating the testicular dysfunction and oxidative stress resulting from STZ-induction of diabetes.

Sun-drying diminishes the antioxidative potentials of leaves of Eugenia uniflora against formation of thiobarbituric acid reactive substances induced in homogenates of rat brain and liver.

Extracts from leaves of Pitanga cherry (Eugenia uniflora) are considered to be effective against many diseases, and are therefore used in popular traditional medicines. In the present study, the antioxidative effect of sun-dried (PCS) and air-dried (PCA) ethanolic extracts of Pitanga cherry leaves were investigated. The antioxidant effects were tested by measuring the ability of both PCS and PCA to inhibit the formation of thiobarbituric acid reactive species (TBARS) induced by prooxidant agents such as iron (II) and sodium nitroprusside (SNP) in rat brain and liver tissues.