Epidemiology of Rectal Cancer Patients in the Kingdom of Bahrain: A Retrospective Cohort Study.

Aim And Background: As rectal cancer diagnosis becomes more prevalent due to the increased awareness caused by campaigns, this study aims to focus on the demographics of patients diagnosed with rectal cancer in the Kingdom of Bahrain.

Methods: A retrospective cross-sectional study design was conducted on 184 patients diagnosed with primary or second primary rectal cancer. Stage and site of tumor at diagnosis, gender, BMI, family history, histology, and metastasis are discussed throughout the paper.

Effects of Combination Taping Technique on Disability, Functional Capacity, and Knee Isokinetic Torque in Patients with Knee Osteoarthritis: A Blinded Randomized Controlled Study.

Background: Treatments that combine both elastic and rigid taping in knee osteoarthritis have not yet been investigated in the literature. Thus, the purpose of the present study is to investigate how the combination taping technique affects functional status, disability, and quadricep isokinetic torque in cases of knee osteoarthritis. Patient Methods: A total of fifty-four patients were assigned to the experimental group or control group.

Fullerenol nanoparticles and AMF application for optimization of Brassica napus L. resilience to lead toxicity through physio-biochemical and antioxidative modulations.

Crop plants are severely affected by heavy metals (HMs), leading to food scarcity and economical loss. Lead (Pb) is outsourced by use of lead-based fertilizers, batteries, mining, smelting and metal processing. It significantly reduces growth, development and yield of crops cultivated on contaminated sites.

The contraceptive active ingredient levonorgestrel disrupts the physiology of Macrocyclops albidus.

Active pharmaceutical ingredients, such as levonorgestrel (LNG), continue to increase in aquatic ecosystems and are detected in environmental matrices; however, their ability to bioaccumulate and cause reproductive, developmental, and biochemical defects in benthic organisms, such as Macrocyclops albidus, is unknown. This study investigated the effects of LNG on the oxidative stress response, reproduction, and development of M. albidus.

New α-glucosidase inhibitors and antioxidants in optimized Jack leaves extract identified by gC-MS-based metabolomics and molecular docking.

Our earlier research demonstrated α-glucosidase inhibitory (AGI) and antioxidant activities of the optimised extract of leaves. It was reported having numerous compounds, although it was unclear which compounds exhibit the bioactivities as well as their binding interaction to the enzyme. This study aimed to identify the compounds possessing AGI and antioxidant activities in the extract utilising GC-MS-based metabolomics, and to analyse the ligand-enzyme binding interactions molecular docking.

Survey of anatomic and clinical pathology services and infrastructure in Nigeria.

Objectives: The paucity of data regarding the availability and extent of diagnostic medical services across sub-Saharan Africa hinders appropriate allocation of resources to improve health care in these regions. We assessed anatomic pathology (AP) and clinical pathology (CP) services in Nigeria, one of the most populous and fastest-growing countries in the world.

Methods: Two individual surveys (AP focused and CP focused) were developed by subject matter experts and administered to individuals involved in pathology and laboratory medicine diagnostic services at hospitals and laboratories across Nigeria between June and August 2022 using the American Society for Clinical Pathology email listserv.

Correction: Circulating microRNAs as potential biomarkers of early vascular damage in vitamin D deficiency, obese, and diabetic patients.

[This corrects the article DOI: 10.1371/journal.pone.

A Case Report on Sternal Tuberculosis Osteomyelitis: From Diagnosis to Recovery.

Sternal tuberculosis (TB) is a rare extrapulmonary manifestation of TB that usually manifests with nonspecific symptoms. Timely diagnosis and intervention are essential to avoid complications. Here, we discuss a case involving a 46-year-old male who experienced right scapular pain for six months and sternal swelling for 11 months.

A Double-Blinded Randomized Controlled Trial: Can Pulsed Electromagnetic Field Therapy Be a Novel Method for Treating Chronic Rhinosinusitis?

: Pulsed electromagnetic field (PEMF) therapy offers a promising approach to treating inflammatory diseases. Its notable anti-inflammatory and antimicrobial effects and enhancement of microcirculation in the nasal mucosa make it a valuable treatment option. Despite its potential, the use of PEMF for chronic rhinosinusitis (CRS) is still in its early stages, with limited exploration of its effectiveness.

The Additional Effect of Neurodynamic Slump and Suboccipital Muscle Inhibition to Passive Stretching of the Short Hamstring: A Single-Blind, Randomized Controlled Trial.

Background/objectives: Hamstring shortening is a significant musculoskeletal condition affecting the posture and mobility of the spine and lower extremities. This study examined the impact of incorporating neurodynamic slump stretch and suboccipital muscle inhibition into passive static stretching on hamstring flexibility in individuals with short hamstrings.

Methods: 117 female participants were classified into three groups: the control group, which received passive static stretch of the hamstring muscle; the neurodynamic slump group, which received neurodynamic slump stretch with passive static stretch; and the suboccipital muscle inhibition group, which received suboccipital muscle inhibition with passive static stretch, for three sessions a week, 10 min each, for four weeks.

Gamma-Aminobutyric Acid (GABA) as a Defense Booster for Wheat against Leaf Rust Pathogen ().

Wheat leaf rust, caused by , poses a growing threat to global wheat production, necessitating alternative strategies for effective disease management. This study investigated the potential of gamma-aminobutyric acid (GABA) to enhance resistance to leaf rust in two wheat cultivars: the susceptible Morocco and moderately resistant Sakha 94 cultivar. Our findings revealed that GABA significantly improved resistance in both cultivars to , particularly in Morocco, by mitigating disease severity and reducing pustule density and size while extending both incubation and latent periods.

Environmental stress and salivary cortisol levels in preterm infants.

Background: Preterm infants are exposed to numerous environmental stressors during their Neonatal Intensive Care Unit (NICU) stay, particularly during the first week after birth. The aim of this study is to assess whether salivary cortisol levels are correlated with Neonatal Infant Stressor Scale (NISS) scores in preterm infants during the first week of life. We also quantified the changes in both NISS scores and cortisol levels in the first week, and whether cortisol levels are associated with gestational age.

IL-8 and PI3K pathway influence the susceptibility of TRAIL-sensitive colorectal cancer cells to TRAIL-induced cell death.

Background: Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an apoptosis inducer that exhibits an ideal therapeutic safety profile with less adverse effects than conventional chemotherapy. However, the occurrence of TRAIL resistance has been reported in various cancers including colorectal cancer (CRC). Substantial efforts have been channelled towards managing TRAIL resistance including identifying molecular targets.

Noise-Induced Hearing Loss Awareness and Prevention: A Cross-Sectional Study Among the Population of the Southern Region of Saudi Arabia.

Background: Noise-induced hearing loss (NIHL) is a prevalent and preventable health issue globally. This study aims to evaluate the symptoms, knowledge, beliefs, and preventive practices regarding NIHL among the general population of the southern region of Saudi Arabia.

Materials & Methods: A cross-sectional study was conducted from May to July 2024, using a self-administered, validated electronic questionnaire distributed in Arabic via social media platforms.

Prevalence of Sleep Disturbance Potential-Associated Factors among Undergraduate Pharmacy Students in Saudi Arabia.

Background: Many studies across the globe have observed the significant effect of sleep disturbance on the academic achievement of medical students. Objective: This research was conducted to define the prevalence of sleep disturbance and to discover the consequences and management of this condition among undergraduate pharmacy students of Mohammed Al-Mana College for Medical Sciences (MACHS).

Methods: We conducted a questionnaire-based online survey among different levels of MACHS pharmacy students.

Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being.

The gut microbiota and its secreted metabolites play a significant role in cardiovascular and musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a significant threat to cardiovascular and skeletal muscle well-being. Nonetheless, the precise molecular mechanisms underlying these changes remain unclear.

Identification of putative α-glucosidase inhibitors and antioxidants in rhizome using LCMS-based metabolomics and molecular docking.

Metabolite profiling is required to reveal bioactive chemicals in ginger rhizome for supporting its traditional claim as anti-diabetic agent. This study aimed to evaluate α-glucosidase inhibitory (AGI) and antioxidant activities of the rhizome, to identify its putative α-glucosidase inhibitors, and to analyse the protein-ligand interaction of the inhibitors. The ginger extracts were tested to AGI assay and analysed using LCMS-based metabolomics to pinpoint the putative α-glucosidase inhibitors.

Synergistic sequential oxidative extraction for nanofibrillated cellulose isolated from oil palm empty fruit bunch.

This research presents a comprehensive study of sequential oxidative extraction (SOE) consisting of alkaline and acidic oxidation processes to extract nanocellulose from plant biomass. This proposed process is advantageous as its operation requires a minimum process with mild solvents, and yet successfully isolated high-quality nanofibrillated cellulose (NFC) from raw OPEFB. The SOE involved ammonium hydroxide (NH4OH, 2.

Mapping pollution dynamics: utilizing GNOME to model oil spill trajectories in tanker terminals.

The aim of this study is to uncover the multifaceted environmental threats posed by Oil Spill Water Pollution (OSWP) originating from tanker terminals situated in the Qeshm and Hormozgan regions of Iran. In this region, water pollution arises from diverse sources, mostly from ruptured pipelines, corroded valves, unforeseen accidents, and aging facilities. The Qeshm Canal and Qeshm Tanker Terminal emerged as pivotal sites for investigation within this study.