Publications by authors named "Ibrahim Razu"
Article Synopsis
- * In experiments on mice and human subjects, Dex-CI showed a significant reduction in electrical impedance and inflammatory response compared to standard implants.
- * Locally delivered dexamethasone (Dex-local) was found to be ineffective for long-term improvement, indicating that Dex-CI is a better option than current clinical practices for reducing inflammation and improving implant performance.
Analyzing confocal microscopic data of biological samples using the Imaris software poses challenges due to its time-consuming nature involving tedious multiple steps and possibility of human errors. Here, we developed a supervised automation protocol to minimize manual input in cell and spot counting on confocal images obtained from mouse cochlear sections. The protocol increases efficiency by incorporating image recognition and object-oriented macros.
View Article and Find Full Text PDFBackground: Cochlear implants (CIs) restore hearing to deafened patients. The foreign body response (FBR) following cochlear implantation (post-CI) comprises an infiltration of macrophages, other immune and non-immune cells, and fibrosis into the scala tympani, a space that is normally devoid of cells. This FBR is associated with negative effects on CI outcomes including increased electrode impedances and loss of residual acoustic hearing.
View Article and Find Full Text PDFArticle Synopsis
- Cochlear implants (CIs) can help restore hearing in deaf individuals but often lead to negative outcomes due to the foreign body response (FBR), which includes immune cell infiltration and fibrosis.
- This study examines the effects of a specific drug, PLX-5622, that depletes macrophages to see if it can improve this tissue response and enhance neural health post-implantation.
- Researchers used a mouse model to measure the impact of the treatment on cochlear health and the fibrosis response after cochlear implantation, analyzing tissue samples at several time points following the procedure.