Implications of p53 gene mutations on patient survival in transitional cell carcinoma of the bladder: a long-term study.

Objective: To determine the prognostic value of p53 gene mutations and P53 overexpression for predicting the incidence of recurrence, progression and long-term survival of patients with transitional cell carcinoma (TCC) of the bladder.

Methods: Prospective cohort study with 94 consecutive patients diagnosed and treated for TCC. DNA was obtained from tumor tissue to perform PCR-SSCP of p53 exons 5-9, with automatic sequencing of any mutated samples.

[Large retroperitoneal malignant fibrohistiocytoma: report of one case].

Objectives: To report one case of a large retroperitoneal malignant fibrohistiocytoma.

Methods/results: 40-year-old female with the diagnosis of a large right retroperitoneal mass after a study for right flank pain and weight loss over several months. Surgery was performed with excision of a large tumor; the pathologic diagnosis was malignant fibrohistiocytoma.