Publications by authors named "Ibrahim Ozcelik"
Introduction: Bisphenols are widely used in the production of polycarbonate plastics and resin coatings. Bisphenol A (BPA) is suggested to cause a wide range of unwanted effects and "low dose toxicity". With the search for alternative substances to BPA, the use of other bisphenol derivatives namely bisphenol F (BPF) and bisphenol S (BPS) has increased.
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- Researchers used a machine learning model to identify potentially toxic molecules that resemble known drugs, specifically focusing on the arylhydrocarbon receptor activity of anti-Parkinson’s drugs and FDA-approved medications.
- The model successfully identified apomorphine and 73 other FDA-approved drugs as likely active, prompting further analysis to find similar compounds among these.
- A similarity analysis revealed tetrahydrocannabinol (THC) as a notable candidate, and molecular docking studies indicated that THC has a strong binding affinity to dopamine receptor 1, suggesting it could have potential therapeutic effects for Parkinson's disease.