Publications by authors named "Ibrahim Bin Sa'id"
Article Synopsis
- The review focuses on the challenges and methodologies for producing Plasmodium gametocytes in vitro, which is crucial for research in drug and vaccine development.
- A systematic analysis of 23 studies published since 2000 revealed that most in vitro research utilized environmental stressors to induce gametocyte formation, with mature gametocytemia reaching up to 4%.
- The findings emphasize the importance of understanding biological factors for effective gametocyte production and point out the necessity for protocols addressing other Plasmodium species beyond P. falciparum.
Background: Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral treatment before transportation to the hospital in case of severe symptoms with an unavailable parenteral and oral treatment. However, negative cultural perception of the rectal route, and limited access to artesunate suppositories, could limit the use of artesunate suppositories.
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