Vesicular Stomatitis Virus: Insights into Pathogenesis, Immune Evasion, and Technological Innovations in Oncolytic and Vaccine Development.

Vesicular stomatitis virus (VSV) represents a significant advancement in therapeutic medicine, offering unique molecular and cellular characteristics that make it exceptionally suitable for medical applications. The bullet-shaped morphology, RNA genome organization, and cytoplasmic replication strategy provide fundamental advantages for both vaccine development and oncolytic applications. VSV's interaction with host cells through the low-density lipoprotein receptor (LDL-R) and its sophisticated transcriptional regulation mechanisms enables precise control over therapeutic applications.

Toward Universal Health Coverage: What Socioeconomic and Clinical Factors Influence Health Insurance Coverage and Restrictions in Access to Viral Hepatitis Services in Nasarawa State, Nigeria?

Viral hepatitis B and C (HBV and HCV) pose significant public health concern in Nigeria, where access to healthcare and treatment affordability are limited. This study investigated sociodemographic and clinical predictors of health insurance coverage and access to care among patients with HBV and HCV in Nasarawa State, Nigeria. A cross-sectional facility-based study was conducted at two secondary hospitals in Nasarawa State, Nigeria.

Lessons Learned From Global Hepatitis C Elimination Programs.

In 2016, the World Health Organization introduced global targets for the care and management of hepatitis C virus (HCV) infection to eliminate hepatitis C as a public health threat by 2030. Despite significant improvements in testing and treatment, in 2020 only 23% of all persons infected with HCV globally were diagnosed. We explore examples from global hepatitis C programs in Georgia, Rwanda, and Nigeria that have used decentralized and integrated models to increase access to HCV testing.

The challenges of addressing the cholera outbreak in Cameroon.

Cholera is an enteric disease caused by the ingestion of food or water contaminated by the toxins of the bacteria - Its transmission is exacerbated by poor sanitary conditions and poor hygiene practices. Affected individuals may present with severe symptoms such as watery diarrhoea and vomiting that can lead to death within few hours. Cameroon is experiencing its worst cholera outbreak in decades.

Sacrococcygeal Agenesis with Sacral Lipoma in a Child of a Non-Diabetic Mother.

Sacrococcygeal agenesis or caudal regression syndrome is an uncommon disorder in which there is partial or total agenesis of the sacrum with or without lumbar involvement. Very few cases have been reported in the literature. We report a case of a 7-year-old child of a non-diabetic mother who presented with complaints of urinary and faecal incontinence since birth.

Short-term dynamics and long-term relationship between natural gas consumption and economic growth in Nigeria: an ARDL approach with breaks.

This paper investigates the short-term dynamics as well as the long-term relationship between natural gas consumption and economic growth in Nigeria, taking breaks into account. The techniques employed include Shahbaz-Omay-Roubaud unit root test with sharp and smooth breaks and autoregressive distributed lag (ARDL) model with breaks. The results revealed that natural gas consumption is positively related to growth both in the short-term and long-term but only significant in the latter.

Effect of Using Different Chemical Dispersing Agents in Grain Size Analyses of Fluvial Sediments via Laser Diffraction Spectrometry.

Laser diffraction spectrometry allows for efficiently obtaining high-resolution grain size data. However, pretreatment and dispersion of aggregates in sediment samples are essential pre-requisites for acquiring accurate results using this method. This study evaluates the effectiveness of five dispersing agents in deflocculating the investigated fluvial sediments and the resulting grain size distribution obtained by laser diffraction spectrometry.

Alpha Amylase Inhibitory Potential and Mode of Inhibition of Oils from (Garlic) and (Onion).

Background: Alpha amylase inhibitors are used in the treatment of type II diabetes mellitus. and , widely consumed as spices have several medicinal uses which include their traditional use in the management of diabetes. This study was conducted to investigate the alpha amylase inhibitory potential and mode of inhibition of and oils.

Impact of socio-demographic factors on the mitigating actions for climate change: a path analysis with mediating effects of attitudinal variables.

Socio-demographic factors play a significant role in increasing the individual's climate change awareness and in setting a favorable individual attitude towards its mitigation. To better understand how the adversative effects of climate change can be mitigated, this study attempts to investigate the impact of socio-demographic factors on the mitigating actions of the individuals (MAOI) on climate change. Qualitative data were collected from a face-to-face survey of 360 respondents in the Kuala Lumpur region of Malaysia through a close-ended questionnaire.

Knowledge of HIV prevention and willingness to collaborate in vaginal microbicides trials-survey of Nigerian gynecologists.

Background: Gynecologists being the primary care physicians and advocates for women sexual and reproductive health are critical in delivering messages on effective intervention to prevent heterosexual HIV transmission. Their knowledge and opinions on the effectiveness of HIV prevention technologies may influence the acceptance and use of these technologies among women at risk.

Methods: A cross sectional survey was self-administered to Nigerian gynecologist attending an Annual Scientific conference; "Kanon Dabo" between November 17 and 21, 2009, in Kano, Nigeria.

Splenic rupture and intracranial haemorrhage in a haemophilic neonate: case report and literature review.

Splenic rupture and intracranial haemorrhage are life-threatening conditions infrequently encountered in neonates without history of birth trauma. External manifestations of birth trauma; namely, capput succadeneum and cephalhematoma, when present raise suspicions for more serious intracranial or visceral damage. Rupture of normal spleen without an obvious source of trauma in haemophilic neonate is a rare event.

Review of intrauterine adhesiolysis at the Aminu Kano Teaching Hospital, Kano, Nigeria.

Background: Hysteroscopic adhesiolysis is shown to significantly improve the outcome of intrauterine adhesions (IUA). The Minimally Invasive Surgical Unit (MISU) of our Department recently acquired a hysteroscope which is being used for hysteroscopic adhesiolysis among others.

Materials And Methods: There were 57 patients diagnosed to have IUA of which 54 case notes were available for analysis, giving a retrieval rate of 95%.