Assessing the effectiveness of topical betamethasone to treat chronic chilblains: a randomised clinical trial in primary care.

Background: GPs prescribe topical corticosteroids to patients with chronic chilblains despite poor evidence for their effectiveness. The authors of the current study therefore decided to assess the effectiveness of topical steroids in a primary care setting.

Aim: To assess the effectiveness of topical application of betamethasone valerate 0.

Nifedipine vs Placebo for Treatment of Chronic Chilblains: A Randomized Controlled Trial.

Purpose: Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial. We aimed to confirm the proposed superiority of oral nifedipine 60 mg per day over placebo for treatment of chronic chilblains in primary care.

Methods: We performed a randomized, placebo-controlled, double-blind, crossover trial, closely following the design of the older trial.

Phenotypic familial aggregation in chronic chilblains.

Background: Our clinical observations and two earlier studies indicate familial clustering to be involved in chronic chilblains. Demonstrating phenotypic familial aggregation is a next step to investigate the origin of familial clustering.

Objective: This study was initiated to assess evidence for phenotypic familial aggregation in chronic chilblains.