Preimplantation genetic diagnosis: a national multicenter obstetric and neonatal follow-up study.

Objective: To study whether women conceiving after preimplantation genetic diagnosis (PGD) and their children have greater risks of adverse pregnancy and birth outcomes compared with children conceived spontaneously or after IVF with or without intracytoplasmic sperm injection (ICSI).

Design: Historical cohort study.

Setting: Not applicable.

Derivation and characterisation of hESC lines from supernumerary embryos, experience from Odense, Denmark.

The derivation and characterisation of human embryonic stem cells provides a source of pluripotent stem cells with potential for clinical applications. Utilising locally sourced embryos from two IVF clinics, we derived and characterised five new cell lines for use in a non-clinical setting. Analysis of clinical data showed that the majority of embryos (94.