Early specialization in formative basketball: A machine learning analysis of shooting patterns in U14 and professional players.

Growing evidence supports that early sport specialization in children and adolescents may compromise long-term athlete development and high-performance acquisition. This study aimed to determine the presence of specialised shooting roles in formative men's basketball players compared to professionals. Data from shot charts of U14 and professional basketball players during the 2020-21 and 2021-22 seasons were retrieved.

Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources.

Cancer cells in acidic tumor regions are aggressive and a key therapeutic target, but distinguishing between acid-exposed and hypoxic cells is challenging. Here, we use carbonic anhydrase 9 (CA9) antibodies to mark acidic areas in both hypoxic and respiring tumor areas, along with an HRE-GFP reporter for hypoxia, to isolate distinct cell populations from 3D tumor spheroids. Transcriptomic analysis of CA9-positive, hypoxia-negative cells highlights enriched fatty acid desaturase activity.

The Persistence of Biologic Therapies for Psoriatic Arthritis: A Narrative Review.

Drug persistence is a crucial measure of long-term efficacy, safety, and patient satisfaction. Lack of persistence can increase healthcare costs and morbidity and mortality rates. This review aimed to consolidate available data on drug persistence for various biological treatments used as the primary intervention for psoriatic arthritis and identify factors associated with nonpersistence.

In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis.

Background: Immunogenic cell death (ICD) and ferroptosis have recently emerged as key factors in the anticancer immune response. Among the treatments able to induce ICD and the associated release of danger signals is photodynamic therapy (PDT). Ferroptosis for its part results from lipid peroxidation and is induced by CD8 T cells to kill nearby cancer cells on IFN-γ production.

Neuromuscular Load in Professional Women's Handball: Segmentation of the Player Load and the Impacts at Group and Individual Level.

Handball is a team sport characterised by physical interaction with other opponents. This interaction produces a high load on the players that can manifest itself in various ways, from discomfort to prolonged injuries due to tears caused by excessive load. In order to establish correct protocols for application in women's teams, context- and gender-specific reference data must be available.

A corannulene-based metallobox for the encapsulation of fullerenes.

A corannulene-bis-N-imidazolium salt was used for the synthesis of two corannulene-bis-N-heterocyclic carbenes of dirhodium(i) complexes of formula (corannulene-di-NHC)[RhCl(COD)] and (corannulene-di-NHC)[RhCl(CO)]. Both complexes were characterized by spectroscopic techniques, and the electron-donating properties of the corannulene-di-NHC ligand were studied by means of infrared spectroscopy and cyclic voltammetry. The complex (corannulene-di-NHC)[RhCl(COD)] was used for the encapsulation of fullerenes C and C, generating host-guest complexes with 2 : 1 stoichiometry, as evidenced by H NMR and ITC titrations.

Discrete Quadruple Stacks Formed in a Nanosized Metallorectangle.

An iridium-cornered nanosized metallorectangle was obtained by combining a quinoxalinophenanthrophenazine-connected Janus-di-imidazolylidene ligand and 4,4'-bipyridine. This metallorectangle was used as host for a series of planar molecules, including pyrene, triphenylene, perylene, coronene, and N,'-dimethyl-naphthalenetetracarboxy-diimide (NTCDI). The binding of coronene and NTCDI followed a strongly positive cooperative 1:2 stoichiometric binding model, as the inclusion of the first guest generates the geometrical requirements for the optimum encapsulation of the second planar molecule.

Myelin dystrophy impairs signal transmission and working memory in a multiscale model of the aging prefrontal cortex.

Normal aging leads to myelin alterations in the rhesus monkey dorsolateral prefrontal cortex (dlPFC), which are positively correlated with degree of cognitive impairment. It is hypothesized that remyelination with shorter and thinner myelin sheaths partially compensates for myelin degradation, but computational modeling has not yet explored these two phenomena together systematically. Here, we used a two-pronged modeling approach to determine how age-related myelin changes affect a core cognitive function: spatial working memory.

Comparative metabolomics reveals how the severity of predation by the invasive insect Cydalima perspectalis modulates the metabolism re-orchestration of native Buxus sempervirens.

The recent biological invasion of box tree moth Cydalima perspectalis on Buxus trees has a major impact on European boxwood stands through severe defoliation. This can hinder further regrowth and threaten survival of populations. In a mesocosm approach and controlled larval density over a 2-month period, responses of B.

Examining the Effects of Altitude on Workload Demands in Professional Basketball Players during the Preseason Phase.

Basketball involves frequent high-intensity movements requiring optimal aerobic power. Altitude training can enhance physiological adaptations, but research examining its effects in basketball is limited. This study aimed to characterize the internal/external workload of professional basketball players during preseason and evaluate the effects of altitude and playing position.

Sarcoidosis and ulcerative colitis: overlap or coexistence.

We show an unusual case of ulcerative colitis and sarcoidosis. This case has detailed images of skin lesions, biopsies and PET-CT results. There is limited evidence regarding the association of inflammatory bowel disease and other granulomatous diseases, especially sarcoidosis.

Exploring the geometry of the bifurcation sets in parameter space.

By studying a nonlinear model by inspecting a p-dimensional parameter space through -dimensional cuts, one can detect changes that are only determined by the geometry of the manifolds that make up the bifurcation set. We refer to these changes as geometric bifurcations. They can be understood within the framework of the theory of singularities for differentiable mappings and, in particular, of the Morse Theory.

Effect of COVID-19 on Key Performance Indicators of Spanish Professional Soccer League.

The unprecedented COVID-19 health crisis severely disrupted global sports in 2020, prompting lengthy suspensions followed by resumed competitions under abnormal behind-closed-doors conditions without fans. These disruptions necessitated tactical adaptations by coaches and teams, attempting to still achieve successful outcomes. This study investigates the pandemic's impacts on performance metrics and indicators within Spanish professional soccer.

Intensity Thresholds for External Workload Demands in Basketball: Is Individualization Based on Playing Positions Necessary?

Currently, basketball teams use inertial devices for monitoring external and internal workload demands during training and competitions. However, the intensity thresholds preset by device manufacturers are generic and not adapted for specific sports (e.g.

Non-Infectious Uveitis and Pregnancy, is There an Optimal Treatment? Uveitis Course and Safety of Uveitis Treatment in Pregnancy.

In pregnancy, a plethora of factors causes changes in maternal immunity. Uveitis flare-ups are more frequent in the first trimester and in undertreated patients. Management of non-infectious uveitis during pregnancy remains understudied.

Guest-Shuttling in a Nanosized Metallobox.

An iridium-conjoined long and narrow metallorectangle was obtained by combining a quinoxalinophenanthrophenazine-connected Janus-di-imidazolylidene ligand and pyrazine. The size and shape of this assembly together with the fused polyaromatic nature of its panels provides it with properties that are uncommon for other metallosupramolecular assemblies. For example, this nanosized 'slit-like' metallobox is able show very large binding affinities with planar organic molecules in such a way, that the cavity is asymmetrically occupied by the guest molecule.

Medical supervised duodenal-enteral feeding for the treatment of overweight and obesity: MESUDEFT.

Background: the development of specialised nutritional support techniques allows the maintenance of an adequate supply of nutrients in those patients in whom oral feeding is not possible or is insufficient in relation to their requirements, trying to improve the quality of life, especially in those with chronic diseases. Methods: single-center clinical study carried out in a clinical-nutritional center consisting of a medically supervised nasogastric-duodenal tube feeding treatment for overweight, obesity and increased body fat percentage in patients requiring it by means of duodeno-enteral feeding, expecting losses of more than 10 %. Results: twenty-nine patients completed the protocol (20.

Universal Access to On-Demand Treatment of Patients with Hereditary Angioedema, the Chilean Experience.

In Chile, patients with hereditary angioedema (HAE) type I and type II are protected under Ley Ricarte Soto (LRS), which guarantees access to on demand plasma-derived C1-INH (pdC1-INH) since 2018. We aimed to analyze the first 3 years of LRS. Review of the LRS database between 2018 and 2021.

Analysis of the External and Internal Load in Professional Basketball Players.

The quantification of the external load and internal load of professional players is of vital importance since it provides a great deal of information on the state of the physical condition of athletes during competition and training. The aim of the present study was to quantify the external load and internal load of the players of a first level team of the Spanish basketball league for two weeks corresponding to the pre-season 2022/2023. Seventeen load variables were analyzed and organized into kinematics external load, neuromuscular external load, and internal load.

Myelin dystrophy in the aging prefrontal cortex leads to impaired signal transmission and working memory decline: a multiscale computational study.

Normal aging leads to myelin alternations in the rhesus monkey dorsolateral prefrontal cortex (dlPFC), which are often correlated with cognitive impairment. It is hypothesized that remyelination with shorter and thinner myelin sheaths partially compensates for myelin degradation, but computational modeling has not yet explored these two phenomena together systematically. Here, we used a two-pronged modeling approach to determine how age-related myelin changes affect a core cognitive function: spatial working memory.

Importance of Maintaining Net Position in Men's and Women's Professional Padel.

The objective of this research was to analyze the importance of maintaining the net position in men's and women's professional padel. The data sample was drawn from 2,756 padel rallies ( = 1,434 men's and = 1,322 women's) in matches played during the 2021 season of the World Padel Tour circuit. The results showed that there was no net exchange in 50.