[Problems and specific features of antituberculous work among pediatric population].

The paper defines the problems and priorities in putting antituberculous measures into effect among children. The formation of risk groups, the use of the compulsory diagnostic minimum during their examination for tuberculosis, the increase of the scope and quality of immunoprophylaxis, the phthisiologist's contacts with general medical network are the main thing in work on early detection and prevention of tuberculosis. The sanatorium stage assumes a great significance under the present conditions due to changes in the periods and treatment regimen of patients with tuberculosis.

[Current socioepidemiologic and clinico-pathogenetic aspects of pulmonary tuberculosis in the Republic of Moldova].

Among the first detected patients, there was a reduction in the proportion of subjects with posttuberculous changes in the lung decreases in the presence of the deteriorating epidemiological situation. Risk factors of social diseases are of much importance in the development of tuberculosis at present. Infiltrative processes with lung tissue destruction and bronchogenic dissemination are essential in the clinical pattern of the disease.

[Detection of Mycobacterial antigens in tuberculous pleuritis, empyema and meningitis].

Mycobacterial antigens were identified by inhibition solid-phase enzyme immunoassay specific antibodies to M.H37Rv labelled with horse radish peroxidase in 20, 27, 24, 47 and 21 patients with tuberculous pleurisy, tuberculous empyema, meningitis, pleurisy and nontuberculous empyema, respectively. Mycobacterial antigens were found more frequently and in greater quantities in pleural and cerebrospinal fluids in tuberculosis than in the above nontuberculous affections.

[Contemporary methods in the diagnosis and treatment of intrathoracic tuberculosis in children].

Reduced chemotherapy courses (6-10 months) were studied for effectivity in 108 children with advanced intrathoracic tuberculosis. Intramuscular isoniazid, pyrazinamide+rifampicin produced a complete response in 87.9% of the cases who suffered side effects 2 times less frequently.

[Risk factors of the development of destructive forms of pulmonary tuberculosis in children].

Data are presented on the follow-up of 120 children between the ages of 3 months and 14 years with different forms of destructive pulmonary tuberculosis. The factors responsible for the origination of destructive tuberculosis include the absence or improper conduction of BCG vaccination, contact with patients sick with active pulmonary tuberculosis at the moment of detection or primary contamination, the absence of systematic and high-quality tuberculosis diagnosis; childhood infectious diseases, pneumonias, bronchitis, untimely diagnosed poorly and well manifested forms of intrathoracic tuberculosis in children of the risk groups.

[Disseminated tuberculosis of the lungs in children].

The infiltration phase of disseminated pulmonary tuberculosis has recently become a severe form of tuberculosis in children. It is accompanied by bacillary excretion (61.3%), lung tissue destruction (29.

[New methods of prevention, diagnosis and treatment of tuberculosis in children].

The follow-up included two groups of schoolchildren: 862 were repeatedly given BCG and 725, BCG-M vaccines. It was demonstrated that both vaccines had the same effectiveness and the latter could also be used. Upright tomographic findings in 70 children showed that it was highly informative for the diagnosis of intrathoracic tuberculosis in children, especially for that of bronchoadenitis.

[Detection of destructive pulmonary tuberculosis in children at a hospital for somatic diseases].

Tuberculosis-related examination of 123 children during hospital treatment in 2 pneumologic departments has revealed 9.8% of tuberculosis patients. Among the children with destructive lung processes one-third had tuberculosis in a destructive phase.