[Role of calcium ions in frequency accomodation of rat hippocampal neurons].

Electrophysiological investigations of extracellular Ca ions the influence on the mechanism of frequency accommodation were carried out on isolated rat hippocampal neurones. It is established that interpulse interval during potential generation action linearly depended on quantity of Ca ions, which enter the cell through Ca2+ channels. Analysis of the results has shown that Ca ions influenced the forming and parameters of frequency accommodation in hippocampal neurones, probably via activation of Ca-dependent outward K-currents.

[Immunophenotype of lymphocytes of patients with malignant melanoma and its dynamics during immunotherapy with interleukin-2].

A Mab set was used to study immunological phenotype of lymphocytes of five patients bearing stage IV malignant melanoma and its changes developing in the course of interleukin-2 (Euro cetus) immunotherapy. Patients were shown to have lowered counts of T cells (mainly due to T-helper/inducers), B cells and lymphocytes expressing adhesion and activation molecules as well as abnormal immunoregulatory cell ratio. Two patients receiving interleukin-2 achieved a response.

[Multifactorial analysis in the prognostication of the incidence of recurrences, metastases and survival of patients with squamous cell cancer of the skin].

A retrospective analysis of the data on 116 cases of squamous cell carcinoma of the skin of the body and extremities was undertaken. Eight parameters were found to influence metastasis formation and five-year survival: extent of involvement according to TNM classification, background conditions of tumor development, duration of disease, rate of tumor growth, gross appearance of tumor, site, contour and histologic pattern of malignancy. Recurrence development was influenced by nine parameters including those mentioned above plus extent of surgery.

[Combined treatment of patients with metastases of skin melanoma using cryotherapy].

Cryotherapy or cryotherapy plus intratumoral injection of BCG vaccine were used in combination with either prospidin or imidazole-carboxamide and multidrug chemotherapy including vincristine, dactinomycin and CCNU for the treatment of 106 cases of cutaneous and subcutaneous metastases of skin malignant melanoma. Five-year survival for the entire group was 36 +/- 5.1%.

[Prognostic significance of histologic signs in squamous cell carcinoma of the skin of the trunk and extremities].

One hundred sixteen cases of squamous cell skin cancer were studied: 83 male and 33 female patients, with their age range being 21-73 yr (mean 50.1 +/- 4.3 yr.

[Melanoma of the skin and pregnancy].

Out of 2018 patients, skin melanoma occurred in IO2 (5%) cases during pregnancy. Three-, five- and ten year survival was analysed in the latter cases versus term of pregnancy, abortion and the stage of the disease. Also comparison was made between the said group, another 42 females who developed tumors during lactation period and 599 normally-cycling females of reproductive age who were not pregnant when melanoma appeared (controls).

[Metastases of skin melanoma from unknown primary site].

Out of 3,822 cases of malignant skin melanoma from an unknown primary site, metastases were registered in 53 (1.4%). The male/female ratio was 3:1.

[Complex therapy of melanoma metastases in the lung].

The authors present the therapeutic results of 25 patients with melanoma metastases of the lungs: 9 of them received radiotherapy only, 16 radiotherapy combined with i.v. injection of the antitumor antibiotic dactinomycin.

[Effect of chronic alcoholic intoxication on liver alcohol dehydrogenase activity in progeny].

Effect of chronic alcoholic poisoning on the activity of alcohol dehydrogenase (ADH) in the liver of rats was studied during ontogenesis. The activity of the enzyme was detectable for the first time in the fetal liver days 17-18 of the ontogenesis and reached the level seen in adult rats day 25 after the birth. ADH activity was dramatically increased in the liver of fetuses and progeny of females alcoholized before and during the entire pregnancy period as well as of females alcoholized before and during mating.

[Immunological reactions of skin melanoma patients to nonspecific and adaptive immunotherapy].

Patients with malignant skin melanoma were given different kinds of immunotherapy; nonspecific immunotherapy with BCG vaccine, adaptive immunotherapy with methotrexate or phytohemagglutinin activated autolymphocytes, and also a combination of polychemotherapy with BCG. The state of cell immunity was determined prior to, during and at the end of the therapy, in accordance with the courses. As a result of the conducted therapy an increased level of cell immunity was observed, that usually corresponded to clinical development of the disease.