[The age peculiarities of metabolism and structure of the brain tumors and its clinical significance].

Retrospective analysis of the treatment results in 476 patients, suffering the brain glioma (BG), was conducted. Peculiarities of diagnosis, clinical course and morphological features of the BG in elderly patients were noted. Morphological criteria of meta- bolic paraneoplastic signs were established.

[The peculiarities of stability of vertical posture in patients with segmental lesions of the spinal cord].

Using computer stabilography, vertical posture has been studied in 3 groups of children and adolescences with traumatic lesion of the spinal cord after surgery of congenital myelocele (n=10) and myelodysplasia (n=10) and in 124 healthy controls. Also, an extent of segmental lesions was investigated by electroneuromyography of lower extremities muscles. Patients with pronounced segmental lesion had small-amplitude, -velocity and -frequency variations of body center of gravity (BCG) during standing with visual control.

[Natural head-forelimb coordination in dogs after vestibular de-afferentation].

We studied the influence of the vestibular lesion on the natural head--forelimb coordination. This coordination exists in intact dogs at the early stage of acquisition of the instrumental feeding reaction of tonic forelimb flexion in order to hold a cup with meat during eating when the head is bent down to foodwell. In untrained dogs, the forelimb flexion is preceded by lifting the head bent down to the food; the following lowering of the head leads to extension of the flexed forelimb.

[Kinesthetic characteristics of vertical stability in patients with infantile cerebral palsy].

The study aimed at analyzing, a speed of body center of gravity (BCG) displacement and a frequency of its vibrations in sagittal and frontal planes in healthy adolescents and children as well as patients with spastic diplegia hemiparetic, hyperkinetic and atonic-astatic forms of infantile cerebral palsy (ICP) using a platform of computer stabilography in Romberg position. The results obtained suggest the presence of kinesthetic peculiarities of BCG vibration parameters, characteristic of CCP patients and pathognomic for a certain disease type that can be used for differential diagnosis. A low level of the visual control for BCG displacement speed is a common feature for all CCP types.

[An analysis of the gait in patients with different type of infantile cerebral paralysis].

The issue related with impaired temporal movements as observed in patients with infantile cerebral paralysis (ICP) during walking still needs more research since it is a vital problem. The authors analyzed the temporal parameters of the step and of the phase of the key goniography spots within the stretch of the step cycle. The results are indicative of a presence of specific gait temporal indices typical of all ICP variations; they also reveal such indices typical of a certain disease type.

[New possibilities of the use of space technologies in the treatment of children with injuries of the central nervous system].

The computerized stabilography was used to study the role of the visual analyzer (VA) in vertical posture acquisition and specifics of posture implementation by patients with craniocerebral injury (CCI) wearing suit Adele for dynamic proprioception correction (SDPC). Results of the investigation revealed a decreased vertical stability (VS) of CCI patients and a greater reliance on VA, which may be a compensatory instrument. Following the SDPC course, vertical stability was improved and the VA role in posture acquisition normalized suggesting alteration of the interanalyzer interaction in CCI patients owing to the treatment of proprioception impulsation.

[Various mechanisms of the depriming effect of bacterial endotoxin on drug metabolism].

The effect of an endotoxin from Sh. Boydii on the biotransformation of amidopyrine and acetanilide, the activity of microsomal monooxygenases, hemoxygenase, and xanthine oxidase, the lipid peroxidation (LPO) intensity, the phospholipid spectrum, and the solubilization of microsomal membrane components was studied by intraperitoneal injections (2.5 mg/kg) in rats.

[Regulation of vertical posture in patients with children's cerebral paralysis treated with the method of proprioceptive correction].

Maintenance of vertical posture is a complex coordination act dependent on a multi-level system of regulation. Functional state of the visual system may contribute significantly to the implementation of the mechanisms of vertical posture maintenance. Stabilographic examination of healthy teenagers and patients afflicted with the main CCP forms with the method of dynamic proprioceptive correction revealed dependence of posture stability and involvement of the visual analyzer on sex.

[Use of computer-assisted stabilography and the method of computer-assisted biomechanical study of gait in the diagnosis of posture and motor disorders in patients with different forms of infantile cerebral paralysis].

The paper presents and analyzes the results of assessment of vertical stability and walk in patients with infantile cerebral paralysis before and after dynamic proprioceptive correction, which is of great importance for differential diagnosis of different forms of this disease, for controlling the course of therapeutical measures, for working out criteria for the efficiency of treatment.

[The individual profile characteristics of cerebral interhemispheric asymmetry during visual stimulation in healthy subjects and in patients with the spastic form of infantile cerebral palsy].

Individual profiles of brain interhemispheric asymmetry (IPA) and stability in maintenance of the vertical posture have been studied in healthy children and adults and patients with the spastic form of the infantile cerebral palsy before and after visual stimulation. The IPA were built on the basis of motor asymmetry of hands, asymmetry of visual half-fields, and asymmetry of muscle extension tone in vertical position in Romberg test at computer stabilograph. The visual stimulation was realized by unilateral tachistoscopic administration of a verbal stimulus in the visual half-field on the side of worst detection of the master stimulus during the procedure of initial IPA construction.

[The influence of space loading suits on interhemispheric asymmetry of the brain in infantile spastic cerebral palsy].

The paper presents the study concerning influence of somatosensory stimulation (single wearing of either space loading costume "PENGUIN" or its modification--"ADELY" costume) on the individual profile of interhemispheral cerebral assymmetry (IPIHCA) in patients with spastic form of infantile cerebral paralysis (ICP). The computer stabilograph analyzed motor arms' asymmetry, sensory asymmetry of visual hemiareas, asymmetry of the position of centre of gravity. It is shown that peculiarities of the realization of the standing position either with visual control or without it both in healthy individuals and in patients depended on initial IPIHCA.

[Changes in individual profiles of cerebral hemispheric asymmetry during somatosensory stimulation due to wearing of G-suits by healthy adults and children].

Presented are results of the investigations of individual profiles of the brain interhemispheric asymmetry (IPIHA) in healthy grown-ups and children prior to, during, and immediately after somatosensory stimulation. The somatosensory stimulation was performed by one-time wearing of space g-loading suit PENGUIN and its modification ADELIE. IPIHA was studied by the main functional asymmetries including motor hand asymmetry, sensory asymmetry of the visual hemispheres, body mass center asymmetry (BMA) using a computerized stabilimeter indirectly measuring the muscle tone of contralateral extensor.

[Fiber optics oximetry of blood in the upper bulb of the internal jugular vein in heart surgery].

The authors assess the potentialities of a new method; fiber optic oxyhemometry of the blood flowing from the brain (at the level of the upper bulb of the internal jugular vein) during heart surgery. They demonstrate a sufficiently high accuracy of the method. Using it during cardiosurgical operations under artificial circulation, they found it highly informative and sensitive to even suddenly emerging and short-term changes in the ratio of oxygen delivery/consumption by the brain.

[The significance of visual analyzer in controlling the standing posture in individuals with the spastic form of child cerebral paralysis while wearing "Adel" suit].

The paper discussed the results of stabilographic examination of the children suffered from the spastic form of child cerebral paralysis (CCP) treated by means of graded wearing of "Adel" suit which is a modification of the "Penguin" spacesuit. There has been studied the state of 30 children before treatment with the use of "Adel" suit and after the treatment as well as following the several courses of wearing the suit. Besides the patients, eleven healthy volunteer subjects (control group) were examined.

[Role of vestibular and visual analyzers in changes of postural activity of patients with childhood cerebral palsy in the process of treatment with space technology].

The paper presents the findings of stabiligraphic investigations of children afflicted with the hyperkinetic child's cerebral paralysis treated with the method of graduated wearing suit ADELI. This suit is a modification of space-designated PINGUIN used to counteract the adverse effect of long-term microgravity on the skeletal muscles and the skeleton. 30 children were investigated prior to, immediately after, and in a delayed period after this treatment.

[Vitamin A and enzyme systems of metabolic activation of genotoxic compounds].

The study was undertaken to study the effects of N-nitrosodimethylamine (NDMA) on the formation of single-strand DNA breaks and gamma-glutamyltransferase-positive knots, the status of the enzymatic systems involved in NDMA metabolism and some other biochemical parameters when rats were on retinol-deficient diets and when they were given excessive vitamin A. The action of retinol on NDMA effects were analyzed by evaluating the activity of glutathione-S-transferase (EC 2.5.

[Transport of 2,5-dimethoxy-4-methylamphetamine by macroheterocycles across erythrocyte membranes].

Transport of 2,5-dimethoxy-4-methylamphetamine across human erythrocytes by the 18-crown-6, monoaza-15-crown-5 and diaza-18-crown-6 is studied and evaluated spectrophotometrically. It is shown that crown-ethers at low concentration (1-2 mM) protect erythrocytes against their natural homolysis. 2,5-dimethoxy-4-methylamphetamine provides 2-5% hemolysis of erythrocytes.

[The influence of modulators of enzyme activity on the pharmacological effect of thiopental sodium and ketamine and on the pharmacokinetics of thiopental sodium].

The rat experiments studied the impact of inductors and inhibitors of enzymatic activity of xenobiotic metabolism on the pharmacological activity of sodium thiopental and ketamine and on the pharmacokinetics of sodium thiopental. Cocarboxylase, cobalt chloride and cimetidine enhanced the pharmacological action of sodium thiopental, but failed to exert any action on the effect of ketamine. The preparations of vitamin K, particularly vikasol and menadione sodium bisulfite, and phenobarbital attenuated the effects of these anesthetics, but tocopherol unchanged it.

[The prolonged use of calcium antagonists in myocardial infarct in rats: their effect on hemodynamics and the contractile function and morphology of the heart muscle].

Experiments on rats with myocardial infarction induced by occlusion of the left coronary artery were made to explore the influence of calcium antagonists injected intraperitoneally for a long time (daily, for 21 days) on hemodynamics, contractile function and morphology of the heart muscle. It has been shown that verapamil (0.5 mg/kg), diltiazem (2 mg/kg) and nimodipine (20 micrograms/kg) do not exert under those conditions any noticeable effect on pump and contractile heart functions.

[Synthesis, conformation analysis, and antiviral activity of benzimidazole ribofuranosides].

To study the structure-biological effect correlation in the series of nucleoside analogues containing deazapurines, a number of 2-R-benzimidazole 1-beta-D-ribofuranosides (R = H, CF3, SCF3, CH2SCF3, CH2Ph, CH2CN) have been prepared by the modified silyl method. On the basis of CD and PMR data it was shown that the compounds exist in solution mainly as syn-conformers. Calculation of the furanose ring pseudorotation parameters in terms of N-S model indicates the predominance of S-population.