[The informative laboratory biomarkers for detection of negative impact of vibration on organism of workers].

The analysis was carried out concerning new characteristics of diagnostic informativeness of particular biochemical, immunologic, cytochemical and hematologic indicators under impact of vibration on human organism. It is established that high diagnostic informativeness is typical for indicators of oxidation metabolism (alpha-superoxide dismutase, myeloperoxidase in neutrophils, alpha-tokopherol), humoral immunity (IgA, IgG), hematologic indicators (corpuscular volume, peroxide hemolysis of erythrocytes, thrombocytes aggregation velocity) and level of creatinine in urine reflecting damages of muscular tissue. The levels of biomarkers mentioned above begin to alter in healthy workers and in individuals under suspicion of vibration disease.

[Influence of perlite sand on the skin in experiment].

In the present work influence of perlite sand has been studied on a skin of Sprague-Dawley male rat (300-350 g). The biopsy of intact rat skin has been used as control. Contact of the perlite sand with animals' skin causes the reaction of an inflammation amplifying with increase of duration of the influence of substance.

[The levels of enzymes of blood neutrophilic leukocytes during the impact on the organism of vibration, vibration in aggregate with nickelous dust and nickel hydroaerosol].

The predominant impact of vibration and vibration in aggregate with nickelous dust and nickel hydroaerosol on the organism of workers administer significant influence on the levels of blood neutrophilic leukocytes and such neutrophil enzymes as acid and alkaline phosphatase and myeloperoxidase. In addition to that the activity of acid and alkaline phosphatases increases and the activity of myelopemroxidase reliably decreases. The intensive alteration of enzymes' activity develops already on the preclinical stage and even worsens in patients with vibratory disease.

[The epidemiology, risk factors and present-day aspects of allergic disease prevention in an industrial center].

The article is dedicated to the topical problem of allergic diseases in various population groups of a large industrial region of Moscow suburb, and presents a brief review of present-day epidemiological data on allergic pathology prevalence as well as authors' own data on the morbidity of bronchial asthma, allergic dermatoses, and allergic rhinitis. The paper also contains the results of an analysis of allergic pathology dynamics within 5 to 10 years, and a retrospective analysis of allergic pathology structure in adolescents. The researchers undertook a multifactor analysis of population habitat in the town Mitishchy, based upon ecological and hygienic data concerning atmospheric air and water composition.

[The manifestation of immune reactions and the chromium content of the blood in patients with occupational allergic dermatoses].

One of the mechanisms responsible for occupational dermatoses of constructors in contact with Cr-containing substances is supposed to be antibodies production as a result of Cr ion migration in the blood. The authors' measurements led them to the conclusions that no significant rise in blood Cr content occurs with an increase in the service duration, there is a close relationship between Cr blood concentrations and specific skin tests as well as between blood Cr and allergic manifestations. In patients with initial and established forms of occupational dermatosis the number of positive responses to Cr skin tests and frequency, intensity of allergic reactions grow with elevation of Cr concentrations in the blood.