[Thrombosis of the sinus durae matris as a complication of therapy in patients with Hodgkin lymphoma].

Aim: To describe thrombosis of the sinus durae matris (TSDM) in lymphomas.

Subjects And Methods: 402 patients with Hodgkin lymphoma were treated using the BEACOPP-14 protocol in 2006 to 2013. Thrombotic events occurred in 6% of the patients, including 3 (0.

[Tuberculous sacroiliitis in a patient with Gaucher disease].

Gaucher disease (GD) is an inherited enzymatic defect resulting from a deficiency of acid [3-glucosidase, a lysosomal enzyme involved in the degradation of cell metabolic products. The major clinical manifestations of GD are hepatosplenomegaly, cytopenia, and bony involvement varying from asymptomatic osteopenia to severest osteoporosis and ischemic necrosis to develop irreversible orthopedic defects. Timely enzyme replacement therapy with recombinant glucosidase makes it possible to arrest disease progression and to prevent damage to the vital organs.

[Diagnosis of cryptococcal encephalitis in a patient with mature B-cell lymphoblastic leukemia].

Fungal meningoencephalitides are one of the most menacing infectious complications in hematologic cancer patients in the presence of myelotoxic agranulocytosis. Due to diagnostic difficulties, mortality in these cases can be as high as 100%. The causative agent of cryptococcosis is Cryptococcus neoformans; damage to the brain arachnoid membranes and substance is diagnosed in 70-90% of cases.

[Immunophenotypic characteristics of blood lymphocytes and expression of cytokine receptors in newborn infants].

Formation of the immune system during the neonatal period was studied in 88 infants aged 3 days-1 month (gestation age 28-41 weeks) with the primary diagnosis of cerebral ischemia. The patients were allocated to 4 groups based on chronological and gestational age at the moment of examination and a reference group. A total of 16 umbilical blood samples were available for analysis.

[Problems and prospects of care for newborn babies with an extremely low body weight].

The paper is designed to discuss problems of morbidity, treatment, rehabilitation, and late follow-up development in children of extremely low birth weight (500-999 g). Despite the use of modern methods of rehabilitation and nursing, the overwhelming majority of such children develop severe combined somato-neurologic pathology leading to disability (polymorphic lesions in the nervous system, broncho-pulmonary dysplasia, retinopathy, etc.).

[Early computed tomography signs in diagnosis of some pulmonary mycoses in myelotoxic agranulocytosis].

Aim: To characterize minimal CT signs of initial pulmonary lesion in candidomycosis and invasive aspergillesis of the lungs.

Material And Methods: A multislice computer tomograph Light Speed+ (GE) was used to examine 67 patients with hematological malignancy in the condition of myelotoxic agranulocytosis (MTA). A CT picture considered as early presentation of fungal lesion of the lungs was seen in 25 (37%) of 67 patients.

[Selenium contents in human milk after term and preterm labor and in breast milk substitutes].

Selenium contents in breast milk of Russia's and Vietnam's women after term and preterm childbirth and in breast milk substitutes were studied. The concentration of selenium in breast milk of Russia's women was normal after term and preterm childbirth. The level of selenium in breast milk of Vietnam's women was decreased and could not satisfy completely the need of breasted infants.

[The characteristics of amino acid metabolism in premature infants on different types of feeding].

Analysis of the free amino acids (AA) in a blood plasma of premature infants receiving kinds of baby food has allowed to reveal a feature of AA metabolism. A significant increasing of sum of the free AA and stable contents of aromatic AA have been found in blood of premature infants fed Prepiltti [correction of 'Prepilti'] that testified to adequacy of protein in Prepiltti [correction of 'Prepiltu'] to requirements of premature infants. Also it has been established different changes of concentration methionine and cystine in this group of the babies that confirms a hypothesis about immature of liver enzymes catabolizing a methionine.

[Rhythmic fluctuations in hemoglobin oxygen affinity in premature infants over the space of 24 hours].

The noninvasive method for estimating the affinity of hemoglobin for oxygen (expressed as P50, oxygen tension at 50% hemoglobin saturation) allowed the authors to follow its time variations. Significant changes of P50 during 24 hours were demonstrated to occur in 16 preterm babies (the gestational age 30-37 weeks, body weight 1850-3000 g) with perinatal encephalopathy, along with fluctuations of tcpCO2, tcpO2, and SpO2. The changes of all these variables were rhythmic; the periods of best fitting cosine curves for P50 were 3-35 hours; double amplitudes, 2.

[Hypoxia-induced ischemic brain damage in newborns].

Fetal brain lesions are characterized by multifactorial genesis. Hypoxia is the central pathogenetic syndrome causing various structural changes of the brain and its malformations. A variety of morphological changes explains the polymorphism of clinical symptoms and long-term sequelae.

[Development of arterial pressure rhythm and cardiac contraction rate and effects of beta-adrenomimetic agents].

Blood pressure (BP) and heart rate (HR) rhythms were studied in premature infants (299 profiles ranged 24-106 h at 20--min intervals) and 11-13-year-old children (19 profiles for 48 h at 15-min intervals) to explore ultradian-to-circannual rhythm characteristics in BP and HR in preterm human infant and to elucidate the influence of antenatal betamimetic (BM) exposure on adolescent BP and HR rhythms. A circannual modulation of the 3-h amplitude (A) or MESOR of systolic BP (SBP) and diastolic BP (DBP) was seen mainly in prematures with a positive family history of high BP on the father's (f+) side or with both a patro linous and matro-linous history (f+m+), the circannual modulation of HR ultradian A was statistically significant only in "f- m-" infants. In urine collected at 3 h intervals for 24-h spans from 21 premature infants Na+,K+ and 11-oxycorticosteroids had a significant circadian rhythm.

[Reserves for lowering the neonatal mortality of premature children].

A tendency for a decrease in the rate of neonatal mortality among preterm babies could be followed up in industrialized countries for the current decade. This tendency is less pronounced in the USSR. Therefore newer diagnostic and therapeutic approaches developed in the clinical department of the Scientific and Research Institute of Pediatrics, the USSR Academy of Medical Sciences, could be regarded as reserves for the reduction of neonatal mortality in preterm children.

[Enzyme status of blood cells in premature children during the treatment of omphalitis by helium-neon laser radiation].

Helium-neon laser radiation was employed in the treatment of 27 premature children suffering from omphalitis. It has been established that helium-neon laser radiation produces a favourable effect on the healing and epithelization of the umbilical wound, activates lymphocyte succinate dehydrogenase in premature children. The rate of wound healing correlates with the initial enzymic status, with the number of sessions of laser therapy and the general estimation of the previous development of the child in accordance with the prognostic coefficient of sepsis development.

[Suppurative-inflammatory diseases in newborn infants].

Changes in the etiological patterns of suppurative-inflammatory diseases of neonates during 1978-1988 were analysed. Basic trends in the etiological structure changes, growing numbers of individual microorganism families or species, and changes in the clinical manifestations corresponding to the etiology variation were demonstrated. Preventive antibiotic therapy administered to neonates in the maternity hospital is proved ineffective, and its deleterious effect on the postnatal microbial colonization is shown.

[The role of congenital Enterovirus infection in the pathogenesis of suppurative and inflammatory diseases in newborn infants].

Newborns with suppurative-inflammatory disease were found to be at high risk of intrauterine infection with Coxsackie enteroviruses from mothers with persistent enterovirus infection; in 54.9%, congenital Coxsackie virus infection was confirmed by virus antigen identification in the urine sediment cells and autopsy material. Coxsackie A viruses were identified in 68.

[Use of constant negative pressure around the chest for rehabilitation of external respiration in premature infants with respiratory disorders].

A study was of the effect produced by constant negative pressure around the chest on the clinical course and external respiratory function in premature infants with respiratory disorders. Application of constant negative pressure around the chest was followed by rapid elimination of the clinical manifestations of respiratory disorders, by the improvement of the characteristics of external respiratory function and blood gases.