[Computer technologies in the hygienic studies of children and adolescents].

Computer technologies were used to develop new hygienic technologies of the activities of civil service in providing sanitary and epidemiological well-being to the population, to devise methods for evaluating and predicting the influence of environmental factors on human health. The specific developmental features of the psychophysiological status in schoolchildren were revealed in relation to their age, sex, the hygienic schooling and living conditions, which may substantiate a package of goal-oriented measures for health promotion and preservation in children.

[Clinicofunctional changes of heart in patients with clinically different variants of toxic diphtheria].

A clinicofunctional examination of 72 patients with toxic diphtheria (mean age 36.8 +/- 7.1 years) has been made to study the course and outcome of diphtheria-related damage to the heart.

[General principles of a formal model of the system of occupational training of workers].

The authors suggested a concept of occupational training as four-level system with the subsystems (orientation, selection, education, adaptation) integrated functionally for longer and more effective occupational life. More intensive occupational training through modern educational technologies was proved to strengthen health and qualification of professional schools' graduates providing longer occupational life.

[Physiologic and hygienic problems in improving human life conditions in the North].

Industrial and occupational factors can modify natural processes of human adaptation towards environment, lead to strain of human protective mechanisms and increase risk of various diseases. Defined dependence between industrial, environmental factors and pathologic changes in humans is helpful to justify scientific strategy and tactics for health preservation.

[Prognosis in the treatment outcome of patients with occlusive atherosclerosis of the arteries of lower extremity arteries by evaluation of lipid metabolism].

The authors discuss the results of correlative analysis of the relative content of the main lipid classes in blood of central and regional venous blood flow with the results of treatment of 75 patients with atherosclerosis obliterans of the lower limb vessels in the stage of collateral circulation decompensation. In patients without anatomo-functional reserves of collateral circulation the amount of phospholipids in the venous blood of the affected limb was found to be significantly lower (by more than 22%) than that in blood collected from the vein in the cubital fossa. This regularity may serve as a criterion for prognosticating the results of treatment of patients in the stage of severe decompensation.

[Changes in phosphatidylinositol content in patients with myocardial infarct].

The changes of phosphatidylinositol content in blood of patients with myocardial infarction was studied. A procedure is developed for multiple estimation of phosphatidylinositol content within short-time intervals which enabled one to obtain additional data on the functional state of biomembranes. In the clinical practice the data obtained may be used for diagnosis and evaluation of efficiency of ischemic heart disease treatment.

[The dynamic change in the content of total lipids in myocardial infarct patients].

The dynamics of the content of total lipids (cholesterol and cholesterol esters) was studied in patients with acute large-focal uncomplicated myocardial infarction in different disease periods. Rapid quantitative changes that occur in the content of cholesterol and its esters in the test groups were established to be characterized by marked specificity and by the form of its own in different disease periods (in the acute period--days 2-5 and on day 15--the health status stabilization). It is advisable that the characteristics of the dynamics of rapid reversible changes in the content of total lipids may be used for estimating the status gravity of patients with uncomplicated large-focal myocardial infarction.

[The dynamics of the blood level of phosphatidylinositol in patients with myocardial infarction].

Phospholipids, particularly inositol-containing ones, that serve as secondary messengers and bioregulators of fundamental biochemical processes, essentially contribute to the origination of cardiovascular diseases. These compounds are highly labile and the data on their levels in the blood and its components in various cardiovascular conditions are contradictory. This may be explained by the fact that phosphatidylinositol levels change immediately after blood collection.