Publications by authors named "Iasmym Mendes de Jesus"
The effects of antimicrobial photodynamic therapy (aPDT) with nanotechnology-applied curcumin and 450nm blue led irradiation on multi-species biofilms in root canals.
Lasers Med Sci
November 2023
This study aimed to evaluate the effectiveness of antimicrobial photodynamic therapy (aPDT) utilizing nanotechnology-applied curcumin activated by blue LED (450 nm) on the elimination of microorganisms arranged in multispecies biofilms inside the root canals of extracted human teeth. Forty single-rooted human teeth were used; these were randomized into four experimental groups, each comprising 10 teeth: control group, no treatment; photosensitizer (PS) group, nanotechnology-applied curcumin alone; light group, blue LED used separately; and aPDT group, nanotechnology-applied curcumin activated by blue LED. To carry out the tests, the interiors of the root canals were inoculated with species of Candida albicans (ATCC 90029), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25922), and methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300), using a multispecies biofilm.
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- HIV/AIDS leads to changes in the immune system, causing increased systemic and local infections, particularly in the mouth, due to an altered oral microbiota and the emergence of drug-resistant pathogens.
- Antimicrobial photodynamic therapy (aPDT) using a 660-nm red LED and porphyrin shows promise in treating these oral infections in AIDS patients, offering a potential alternative to conventional treatments.
- A study found that aPDT effectively reduced oral enterobacteria and Streptococcus spp., as well as the overall microbial count, correlating with improvements in immune markers like TCD4 and TCD8 lymphocytes.