A multi-objective optimization framework through genetic algorithm for hyperthermia-mediated drug delivery.

This study presents an approach to the multi-objective optimization of hyperthermia-mediated drug delivery using thermo-sensitive liposomes (TSLs) for the treatment of hepatocellular carcinoma. The research focuses on addressing the non-optimal coupling methods that combine thermal treatments and chemotherapy by employing a Multi-Objective Genetic Algorithm (MOGA) optimization process, in order to identify the right combination of design variables to achieve better treatment outcomes. The proposed model integrates Computational Fluid Dynamics (CFD) analysis using the Pennes' Bioheat equation for tissue heating and a convection-diffusion model for drug delivery.

Optimization of the thermal performance of a lobed triplex-tube solar thermal storage system equipped with a phase change material.

The thermal performance of a PCM-based triple-tube lobed heat exchanger storage system is here simulated and optimized, including performance improvements via lobed surfaces, Y-shaped fins, dispersed multi-walled carbon nanotubes, and metal foams, to be used in combination, or singly. Such computations are done with the finite volume method under different operating conditions. The reason behind this study is to look for solutions to improve the poor thermal performance of phase change materials (PCMs) as thermal energy storage materials, that limits their compactness and instantaneous heat stored/released.

Implementing a group-based online mental well-being program for women living with and beyond breast cancer - A mixed methods study.

Purpose: There is a gap in available mental well-being services in Australia for women diagnosed with breast cancer. This pilot mixed-methods uncontrolled study aimed to assess the feasibility of an online mental health and well-being intervention, the Be Well Plan (BWP), which enables participants to create a personalized, flexible well-being strategy.

Methods: Women diagnosed with stages I-IV breast cancer were recruited into 4 asynchronous groups to participate in the BWP, a 5-week facilitator-led group-based mental health and well-being program.

Microwave ablation modeling with AMICA antenna: Validation by means a numerical analysis.

Background And Objectives: Percutaneous microwave thermal ablation is based on electromagnetic waves that generate dielectric heating, and it is widely recognized as one of the mostly used techniques for tumor treatment. The aim of this work is to validate a predictive model capable of providing physicians with guidelines to be used during thermal ablation procedures avoiding collateral damage.

Methods: A finite element commercial software, COMSOL Multiphysics, is employed to implement a tuning-parameter approach.

Emprint Microwave Thermoablation System: Bridging Thermal Ablation Efficacy between Human Patients and Porcine Models through Mathematical Correlation.

To investigate the in vivo ablation characteristics of a microwave ablation antenna in the livers of humans with tumors, a retrospective analysis of the ablation zones was conducted after applying Emprint microwave ablation systems for treatment. Percutaneous microwave ablations performed between January 2022 and September 2022 were included in this study. Subsequently, immediate post-ablation echography images were subjected to retrospective evaluation to state the long ablated diameter, short ablated diameter, and volume.

The Importance of Measuring Mental Wellbeing in the Context of Psychological Distress: Using a Theoretical Framework to Test the Dual-Continua Model of Mental Health.

Unlabelled: The dual-continua model of mental health suggests that psychological distress and mental wellbeing operate on two distinct yet related continua, both uniquely contributing to overall mental health. Previous literature provides support for the dual-continua model; however, inconsistent methodologies lacking a common theoretical underpinning have led to findings that are difficult to compare across studies. Using archival data, this study aimed to test the following three theoretically derived criteria proposed to accurately examine the dual-continua model: (1) confirming independent existence, (2) disconfirming bipolarity, and (3) quantifying functional independence.

Effects of Pulsed Radiofrequency Source on Cardiac Ablation.

Heart arrhythmia is caused by abnormal electrical conduction through the myocardium, which in some cases, can be treated with heat. One of the challenges is to reduce temperature peaks-by still guaranteeing an efficient treatment where desired-to avoid any healthy tissue damage or any electrical issues within the device employed. A solution might be employing pulsed heat, in which thermal dose is given to the tissue with a variation in time.

The experience of individuals affected by Australia's international border closure during the COVID-19 pandemic.

This study explored the experiences of individuals who reported being negatively affected by Australia's international border closure during the COVID-19 pandemic. Qualitative data from 1930 adults who responded to a cross-sectional online survey exploring the mental health and wellbeing of individuals affected by border closure were analysed using theoretical thematic analysis, drawing on understandings of the relationship between place and wellbeing. Four themes were identified: 'Disconnection from family and social connections', 'Disconnection from a sense of home and belonging', 'Disconnection and sense of self', and 'A desire for reconnection'.

The Effect of Psychological Distress on Measurement Invariance in Measures of Mental Wellbeing.

A growing literature supports the expansion of mental health assessment to include indicators of mental wellbeing; however, the concurrent use of measures of wellbeing and distress introduces potential sources of measurement error. The current study examines whether the mental health continuum short form is invariant to the level of participants' psychological distress. Measurement invariance testing was conducted within an Australian population ( = 8406) who participated in an online survey.

A Group-Facilitated, Internet-Based Intervention to Promote Mental Health and Well-Being in a Vulnerable Population of University Students: Randomized Controlled Trial of the Be Well Plan Program.

Background: A growing literature supports the use of internet-based interventions to improve mental health outcomes. However, most programs target specific symptoms or participant groups and are not tailored to facilitate improvements in mental health and well-being or do not allow for needs and preferences of individual participants. The Be Well Plan, a 5-week group-facilitated, internet-based mental health and well-being group intervention addresses these gaps, allowing participants to select a range of activities that they can tailor to their specific characteristics, needs, and preferences.

Mono- and Multi-Objective CFD Optimization of Graded Foam-Filled Channels.

Graded foam-filled channels are a very promising solution for improving the thermal performance of heat sinks because of their customized structures that leave large amounts of room for heat transfer enhancement. Accordingly, this paper proposes a comprehensive optimization framework to address the design of such components, which are subjected to a uniform heat flux boundary condition. The graded foam is achieved by parameterizing the spatial distributions of porosity and/or Pores Per Inch (PPI).

A cross-sectional investigation of the mental health and wellbeing among individuals who have been negatively impacted by the COVID-19 international border closure in Australia.

Background: The COVID-19 pandemic resulted in the Australian government implementing strict international border closures. However, research has not yet investigated the mental health status of individuals impacted negatively by these international border closures.

Methods: The present study was a cross-sectional online survey of 3968 adults who reported being negatively affected by the border closure during June and July 2021.

Mathematical modeling of microwave liver ablation with a variable-porosity medium approach.

Background And Objectives: Thermal ablation of tumors plays a key role to fight cancer, since it is a minimally invasive treatment which involves some advantages compared to surgery and chemotherapy, such as shorter hospital stays and consequently lower costs, along with minor side effects. In this context, computational modeling of heat transfer during thermal ablation is relevant to accurately predict the obtained ablation zone in order to avoid tumor recurrence risk caused by incomplete ablation, and the same time to save the surrounding healthy tissue. The aim of this work is to develop a more realistic porous media-based mathematical model to simulate a microwave thermal ablation (MWA) of an in vivo liver tumor surrounded by healthy tissue.

Using the Intervention Mapping Approach to Develop a Mental Health Intervention: A Case Study on Improving the Reporting Standards for Developing Psychological Interventions.

Replicating or distilling information from psychological interventions reported in the scientific literature is hindered by inadequate reporting, despite the existence of various methodologies to guide study reporting and intervention development. This article provides an in-depth explanation of the scientific development process for a mental health intervention, and by doing so illustrates how intervention development methodologies can be used to improve development reporting standards of interventions. Intervention development was guided by the Intervention Mapping approach and the Theoretical Domains Framework.

Testing the Differential Impact of an Internet-Based Mental Health Intervention on Outcomes of Well-being and Psychological Distress During COVID-19: Uncontrolled Intervention Study.

Background: During COVID-19, the psychological distress and well-being of the general population has been precarious, increasing the need to determine the impact of complementary internet-based psychological interventions on both positive mental health as well as distress states. Psychological distress and mental well-being represent distinct dimensions of our mental health, and congruent changes in outcomes of distress and well-being do not necessarily co-occur within individuals. When testing intervention impact, it is therefore important to assess change in both outcomes at the individual level, rather than solely testing group differences in average scores at the group level.

A systematic review and meta-analysis of psychological interventions to improve mental wellbeing.

Our current understanding of the efficacy of psychological interventions in improving mental states of wellbeing is incomplete. This study aimed to overcome limitations of previous reviews by examining the efficacy of distinct types of psychological interventions, irrespective of their theoretical underpinning, and the impact of various moderators, in a unified systematic review and meta-analysis. Four-hundred-and-nineteen randomized controlled trials from clinical and non-clinical populations (n = 53,288) were identified for inclusion.

Pennes' bioheat equation vs. porous media approach in computer modeling of radiofrequency tumor ablation.

The objective of this study was to compare three different heat transfer models for radiofrequency ablation of in vivo liver tissue using a cooled electrode and three different voltage levels. The comparison was between the simplest but less realistic Pennes' equation and two porous media-based models, i.e.

Numerical analysis of the pulsating heat source effects in a tumor tissue.

Background And Objectives: Hyperthermia treatment is nowadays recognized as the fourth additional cancer therapy technique following surgery, chemotherapy, and radiation; it is a minimally or non-invasive technique which involves fewer complications, a shorter hospital stay, and fewer costs. In this paper, pulsating heat effects on heat transfer in a tumor tissue under hyperthermia are analyzed. The objective of the paper is to find and quantify the advantages of pulsatile heat protocols under different periodical heating schemes and for different tissue morphologies.

The effects of exterior boundary conditions on a internally heated tumor tissue with a thermoporoelastic model.

Modeling flow field in tumor regions interstitial space is of primary importance, because of the importance of advection in macromolecule drug delivery. Its deformation has also to be taken into account because of the forces caused by the fluid; if the tumor region is not isothermal, this deformation can be also strongly affected by temperature fields. In this paper, the effects of thermal boundary conditions on a tumor region periphery with an internal heat source are investigated.

Effects of pulsating heat source on interstitial fluid transport in tumour tissues.

Macromolecules and drug delivery to solid tumours is strongly influenced by fluid flow through interstitium, and pressure-induced tissue deformations can have a role in this. Recently, it has been shown that temperature-induced tissue deformation can influence interstitial fluid velocity and pressure fields, too. In this paper, the effect of modulating-heat strategies to influence interstitial fluid transport in tissues is analysed.

Improving the Wellbeing of Female Prisoners via Psychological Skills Training: A Feasibility Study.

Prisoners display significantly higher rates of mental disorders and lower mental wellbeing than the general population. The integration of positive psychological interventions in offender supervision has received recent advocacy. The aim of the current pre-post pilot study was to determine the short-term effects of group-based resilience training on mental health outcomes for female offenders and explore intervention acceptability.

Using Internet-Based Psychological Measurement to Capture the Deteriorating Community Mental Health Profile During COVID-19: Observational Study.

Background: The coronavirus disease (COVID-19) is expected to have widespread and pervasive implications for mental health in terms of deteriorating outcomes and increased health service use, leading to calls for empirical research on mental health during the pandemic. Internet-based psychological measurement can play an important role in collecting imperative data, assisting to guide evidence-based decision making in practice and policy, and subsequently facilitating immediate reporting of measurement results to participants.

Objective: The aim of this study is to use an internet-based mental health measurement platform to compare the mental health profile of community members during COVID-19 with community members assessed before the pandemic.

A thermoporoelastic model for fluid transport in tumour tissues.

In this paper, the effect of coupled thermal dilation and stress on interstitial fluid transport in tumour tissues is evaluated. The tumour is modelled as a spherical deformable poroelastic medium embedded with interstitial fluid, while the transvascular fluid flow is modelled as a uniform distribution of fluid sink and source points. A hyperbolic-decay radial function is used to model the heat source generation along with a rapid decay of tumour blood flow.

Positive mental health as a predictor of recovery from mental illness.

Background: High levels of positive mental health protect individuals from mental illness. This study investigates longitudinal change in positive mental health as a predictor of mental illness recovery in a cohort group.

Methods: Using data from the 1995 and 2005 Midlife in the United States cross-sectional surveys (n = 1,723), logistic regression was used to estimate the odds ratio that individuals diagnosed with a mental illness in 1995 would have recovered in 2005 based on whether their level of positive mental health changed over the 10-year period.