[Influence of perlite sand on the skin in experiment].

In the present work influence of perlite sand has been studied on a skin of Sprague-Dawley male rat (300-350 g). The biopsy of intact rat skin has been used as control. Contact of the perlite sand with animals' skin causes the reaction of an inflammation amplifying with increase of duration of the influence of substance.

[The sequence of nephron tubule differentiation in the definitive human kidney during the fetal period].

The regularities of the formation of the undifferentiated renal tubules in the definitive kidney were studied in 174 human embryos and fetuses at 4.5 to 40 gestational weeks. On the basis of the study of morphological and morphometrical parameters of these tubules, it was shown that the increase of the average tubular crossectional area was associated with the consecutive formation of the nephrons of the definitive kidney and the differentiation of the segments of their tubular portions.

[Provisionality phenomenon in the histo- organo- and systemogenesis].

This review summarizes the results of the study of the provisionality phenomenon in the development of the organs of the urinary system (mesonephros, metanephros) in viviparous (human, rat) and oviparous (bird) amniotes, human organs of mixed origin (pituitary, ovary, stomodeum) reparative regeneration of supporting tissues (in humans and Syrian hamster), morphogenesis of primary hepatic cancer developing against the background of superinvasive opisthorchiasis. It is shown that during the development of tissues and organs, the stages of provisional and definitive histo- and organogenesis could be determined; saltatory mechanism is typical for embryonic organogenesis (formation of cartilaginous skeletal primordia, meso- and metanephrons) and foci of oncogenesis. Transformation zones of the type of tissue organization in the epithelium are located in the areas of contacts of the derivatives of different embryonic primordia.

[Effect of negative air ions on respiratory organs and blood].

The effect of negatively charged ions on respiratory organs and blood of rats has been studied. It was shown that the inhaling of negative air ions (NAI) for 60 min with a concentration of NAI at the place of location of animals 320-350 000 ions/cm2 activated the secretion of goblet cells without damaging the mucosa of the trachea and changed the spectrum of proteins of bronchopulmonary lavage. It was also found that the spontaneous production of reactive oxygen species (ROS) by cells of nonfractionated blood after the exposure to NAI increased in both males and females; the intensity of ROS generation induced by opsonized zymosan increased only in females.

[Human pituitary embryonic morphogenesis].

Basic stages of pituitary gland organogenesis were studied using the methods of light microscopy in human embryos at Carnegie stages (CS) 12-23 (25-57 postovulatory days). It is shown that Rathke's pouch (RP) is formed like a traction fold along the whole width of the stomodeum roof in embryos at CS 12 as a result of a neural tube bend, to which the epithelium is closely connected anatomically (attached part of RP front wall) in the middle plane of the embryo. At CS 15 the primordia of hypothalamic infundibulum and of neurohypophysis are formed as a thickening of diencephalic posterior wall.

[Role of provisionality principle in realization of phylembryogeneses].

The analysis of histogenesis of skeletogenic tissues and of organogenesis of the mesonephros and metanephros in higher mammalian animals and man, is presented. The new conception of provisionality is formulated, according to which embryonic primordium and/or its derivatives possess a determined capacity to form, on its course to definitive state, temporary structures (tissues or organs), which fulfil the vital functions in the developing organism and modeling the mechanisms of development and formation of structural and functional units or the whole organ at the level of definitive morphological substrate. Provisionality is regarded as the universal principle in realization of of phylembryogeneses.

[Some regularities in the distribution of autooscillation frequencies in the neuromuscular system].

This paper is devoted to the problem of biofeedback and self-regulation in the human neuromuscular system. On the base of our experimental data we revealed the existence of the three informative frequency band in the range 100-150, 140-210 and 180-300 p.s.