[Our 3-years experience in surgical management of cervical cancer].

Objectives: To share our experience in surgical management of cervical cancer, combined adiotherapy (RT) and neoadjuvant chemotherapy (NCT) and to evaluate the 2-year overall and desease free survival, the incidance and sites of relapses.

Material: One hundred eight cervical cancer patients, staged IB-IVB according to FIGO had been operated on by the author between the period XI. 2003-VI.

[Complications following surgery and radiotherary in 108 patients with cervical cancer].

Objective: To evaluate the most common complications following surgery and radiotherary of cervical cancer based on own experience and to compare them to the complications rates reported by other authors.

Material: One hundred eight patients with invasive cervical cancer, staged (IB-IVB) are enrolled in the study. They all had been operated on in Varna between the period XI.

[Retroperitoneal approach and pelvic peritoneoectomy in the surgical management of advanced ovarian cancer].

Objective: To share our experience in surgical management of advanced ovarian cancer applying a retroperitoneal approach and performing pelvic peritoneoectomy for the achievement of an optimal debulking in this disease.

Material: Thirty eight patients age ranging from 36 to 77 years (average 55,7 years) staged: I - 2 (5,3%), II - 4 (10,5%), //III/ - 28 (73,7%) and IV - 4 (10,5%) had been operated on. Thirty patients presented without previous therapy, 3 - after total abdominal hysterectomy with adnexes, 1 - after supravaginal hysterectomy with adnexes, 1 - after unilateral adnexectomy and 3 - after neoadjuvant chemotherapy.

[COX-2 expression and ovarian cancer].

The aim of the present review is to study the significance of the COX-2 expression for unfavourable prognosis and aggressive clinicopathological parameters in certain malignancies. The main directions for future research on COX-2 as a prognostic factor of decreased survival and predictive factor of chemotherapy resistance in ovarian cancer are discussed.

[A multicenter study of the antimicrobial effect of Macmiror and Macmiror Complex in the treatment of vaginal infections].

Unlabelled: The aim of the present multicentre study was to examine the therapeutic possibilities of the wide-spectrum medicament MACMIROR & MACMIROR COMPLEX for the treatment of the vaginal infections.

Materials And Methods: The study included 159 nonpregnant women among 15 and 54 years (middle age 35.6) with different by kind and intensity colpitis complaints.

[A rare case of a variant cervical polyp in adolescence].

The authors, stress on the importance of the examination of the vagina and the cervix in case of a mucous bleeding at adolescent girls. The following case is being introduced: after examination of a 16-year-old patient who had undergone a two-year treatment for a vaginal discharge, a bleeding polyp, the size of an egg and attached to a leg was found and extirpated. The histological examination read as "a myomatous polyp of the cervical canal with hemorrhagic necrosis".

[Endometriosis in clinical practice].

The authors are investigated the frequency of the cases of genital endometriosis, its most frequent localization and the choice of treatment on 864 women patients who have undergone operations connected with other gynaecological disorders and on 32 women patients, suffering sterility and proved endometriosis. Most frequent are the cases of combination between uterine myoma and endometriosis of the uterine wall-5.74% and with the patients who have undergone surgery for malignant disease between endometrium carcinoma and uterine endometriosis.

[Indices of a threatened pregnancy in the first trimester].

Studies were carried out on 167 pregnant women, divided into 4 groups in accordance with the values of human chorionic gonadotropin (HCH). Fetal death was established by ultrasound in 41 of the pregnant women including all cases with HCG under 5000 IU, but it was also found in 19.18% of women with values of HCG over 10,000 IU.

[The course of pregnancy and labor following artificial insemination].

The course of pregnancy and its final outcome--delivery of alive and viable fetus, is of special significance for women becoming pregnant after artificial insemination because of their limited possibilities for new pregnancy. 131 pregnancies, occurring after artificial insemination with fresh and frozen seminal plasma, were investigated. Analysis of the results showed that in basic lines the course of pregnancy and delivery as well as the state of the newborns did not differ substantially from those of normally conceived women.