Temporalities of peer support: the role of digital platforms in the 'living presents' of mental ill-health.

This paper considers matters of time in online mental health peer support. Significant evidence of the value of peer support exists, with new digital platforms emerging as part of the digitisation of mental health support. This paper draws from a project exploring the impact of digital platforms on peer support through interviews with users of a major UK-based online peer support platform.

Evaluation of an on-farm culture system for the detection of subclinical mastitis pathogens in dairy cattle.

The purpose of this observational study was to compare the performance of a novel on-farm culture (OFC) test with the reference method (RM) in identifying pathogens, and in particular , associated with subclinical mastitis (SCM) in dairy cattle. The OFC test (Mastatest HiSCC; Mastaplex Limited) for SCM uses a cartridge with 2 × 12 wells allowing 1 sample to be analyzed in duplicate (24 wells) or 2 samples analyzed simultaneously, each in 12 wells. Results of the milk analyses are reported hierarchically ( → coagulase-negative staphylococci (CNS) → other gram positive or coliform/gram negative → no bacteria present) and emailed within 24 h.

Digital community assets: Investigating the impact of online engagement with arts and peer support groups on mental health during COVID-19.

The digitisation of mental health support has accelerated since the outbreak of the COVID-19 pandemic. This study investigated the impact of digital engagement with community assets on mental health during COVID-19. Digital engagement is typically not location-bound, but the restricted movement enforced during 'lockdowns' meant that people were primarily accessing digital community assets from their home environments.

In vitro Dissolution Testing of Rifampicin Powder Formulations For Prediction of Plasma Concentration-Time Profiles After Inhaled Delivery.

Purpose: The purpose of this study was to evaluate the in vitro lung dissolution of amorphous and crystalline powder formulations of rifampicin in polyethylene oxide (PEO) and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and to predict the in vivo plasma concentration-time profiles using the in vitro data.

Methods: The in vitro dissolution and permeation profiles of respirable rifampicin particles were studied using a custom-made dissolution apparatus. Data from the in vitro dissolution test were used to estimate the parameters to be used as the input for the simulation of in vivo plasma concentration-time profiles using STELLA® software.

Modeling the interaction of polymeric nanoparticles functionalized with cell penetrating peptides at the nano-bio interface.

The interaction of nanoparticles with Caco-2 monolayers in cell culture underpins our predictions of the uptake of nanoformulations in vivo for drug delivery. Cell-penetrating peptides (CPP), such as oligoarginine, are currently of interest to enhance cellular uptake of bioactives and nanoparticles. This paper assesses the cellular association of poly(ethyl-cyanoacrylate) nanoparticles functionalized with di-arginine-histidine (RRH) in a Caco-2 cell model.

Dynamics and local environment of an aromatic counterion bound to di-chain cationic surfactant bilayers studied by avoided level crossing muon spin resonance: evidence for counterion condensation.

Avoided level crossing muon spin resonance (ALC-μSR) has been used to study the reorientational dynamics of muon-spin-labelled 2,4,6-trimethylbenzoate (246TMB) counterions and their interaction with DODMAC (dioctadecyldimethylammonium chloride) bilayers in the L and L liquid crystalline states. The muoniated radical anion formed by the addition of muonium to the secondary carbons of the aromatic ring of 246TMB is used as a local spin probe. The muon and methylene proton hyperfine parameters and the electron spin relaxation rate () of the muoniated spin probe were determined as a function of temperature by modelling the ALC-μSR spectra with Monte Carlo numerical simulations.

Pharmacokinetics of rifampicin after repeated intra-tracheal administration of amorphous and crystalline powder formulations to Sprague Dawley rats.

Rifampicin is one of the key drugs used to treat tuberculosis and is currently used orally. The use of higher oral doses of rifampicin is desired for better therapeutic efficacy, but this is accompanied by increased risk of systemic toxicity thus limiting its recommended oral dose to 10 mg/kg per day. Inhaled delivery of rifampicin is a potential alternative mode of delivery, to achieve high drug concentrations in both the lung and potentially the systemic circulation.

Studies on the safety and the tissue distribution of inhaled high-dose amorphous and crystalline rifampicin in a rat model.

Inhaled delivery of rifampicin has the potential to achieve high drug concentrations in the lung and the blood for efficient treatment of tuberculosis (TB). Due to its existence as polymorphs, in vivo evaluation of the respiratory tract safety of inhalable amorphous and crystalline rifampicin particles, at clinically relevant high-dose, is necessary. This study investigates the lung and liver safety and the tissue distribution of rifampicin after intra-tracheal administration of high (≥25 mg/kg) doses of amorphous and crystalline powder formulations to Sprague Dawley rats.

Cell-based, animal and H receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers.

Objectives: Ketotifen (K) and its active metabolite norketotifen (N) exist as optically active atropisomers. They both have antihistaminic and anti-inflammatory properties but the S-atropisomer of N (SN) causes less sedation than K and RN in rodents. This study investigated whether this could be related to a lower concentration of SN in brain or a lower affinity of SN for rat brain H receptors.

A STELLA simulation model for in vitro dissolution testing of respirable size particles.

In vitro dissolution testing is a useful quality control tool to discriminate the formulations and to approximate the in vivo drug release profiles. A dissolution apparatus has been custom-made for dissolution testing of dry powder formulations in a small volume of stationary medium (25 μL spread over 4.91 cm area i.

Temporalities of mental distress: digital immediacy and the meaning of 'crisis' in online support.

The Internet is increasingly used to seek support by those suffering with mental distress (Bauman, S. and Rivers, I. Mental Health and the Digital Age.

Crystalline adduct of moxifloxacin with trans-cinnamic acid to reduce the aqueous solubility and dissolution rate for improved residence time in the lungs.

A crystalline adduct of the anti-tubercular drug, moxifloxacin and trans-cinnamic acid (1:1 molar ratio (MCA)) was prepared to prolong the residence time of the drug in the lungs by reducing its solubility and dissolution rate. Whether the adduct is a salt or cocrystal has not been unequivocally determined. Equilibrium solubility and intrinsic dissolution rate measurements for the adduct (MCA) in phosphate buffered saline (PBS, pH 7.

Carrier-free combination dry powder inhaler formulation of ethionamide and moxifloxacin for treating drug-resistant tuberculosis.

This study aimed to develop a combination dry powder formulation of ethionamide and moxifloxacin HCl as this combination is synergistic against drug-resistant (Mtb). L-leucine (20% w/w) was added in the formulations to maximize the process yield. Moxifloxacin HCl and/or ethionamide powders with/without L-leucine were produced using a Buchi Mini Spray-dryer.

Aniracetam does not improve working memory in neurologically healthy pigeons.

Understanding the effects of cognitive enhancing drugs is an important area of research. Much of the research, however, has focused on restoring memory following some sort of disruption to the brain, such as damage or injections of scopolamine. Aniracetam is a positive AMPA-receptor modulator that has shown promise for improving memory under conditions when the brain has been damaged, but its effectiveness in improving memory in neurologically healthy subjects is unclear.

The influence of storage relative humidity on aerosolization of co-spray dried powders of hygroscopic kanamycin with the hydrophobic drug rifampicin.

The purpose of this study was to investigate the influence of storage humidity on aerosolization and physicochemical properties of co-spray dried powders of kanamycin with rifampicin. The powders were stored for one-month in an open Petri dish at different relative humidities (RHs) (15%, 43%, and 75%) and 25 ± 2 °C. The aerosolization (fine particle fraction, FPF) of the powders was determined by a next generation impactor (NGI).

In vitro dissolution testing of respirable size anti-tubercular drug particles using a small volume dissolution apparatus.

A dissolution apparatus that uses a small volume of stationary medium (25 μL) has been developed for in vitro dissolution testing of respirable drug particles and used to evaluate the dissolution of two anti-tubercular drugs, moxifloxacin and ethionamide. Solubilities of moxifloxacin and ethionamide in phosphate buffered saline (PBS, pH 7.4) were 17.

Markov Chain Modeling of Surfactant Critical Micelle Concentration and Surface Composition.

A Markov chain (MC) model has been used to model the following binary surfactant mixtures: linear alkylbenzenesulfonate (LAS4)/octaethylene glycol monododecyl ether (C12E8) at 10 and 25 °C, LAS6/acidic sophorolipid (AS), C12Betaine/C12Maltoside, sodium lauryl ether sulfate (SLES2)/C12E8, and rhamnolipid (R1)/LAS6. The critical micellar concentration and the composition of the adsorbed layer, for each system, can be modeled using the same monomer reactivity ratio values, g and g. This implies that the interactions between the surfactants in the bulk solution and at the interface are the same, within error.

Living 'in between' outside and inside: The forensic psychiatric unit as an impermanent assemblage.

This paper presents analysis from 'a study of staff and patient experiences of the restrictive environments of a forensic psychiatric unit. The paper conceptualises the forensic unit as an impermanent assemblage, enacted in and through practices that hold a future life outside the unit simultaneously near, yet far. We show how the near-far relations between life inside and outside the unit operate in three ways; 1) in relation to the 'care pathway', 2) practices of dwelling, and 3) creating and maintaining connections to life 'beyond' the unit.

Preadmission predictors of academic performance in a pharmacy program: A longitudinal, multi-cohort study.

Introduction: This study examined the extent to which a preadmission health science program and demographic variables predicted academic performance throughout an undergraduate pharmacy degree (BPharm) program.

Methods: A longitudinal, multi-cohort study was undertaken of 557 students admitted to the University of Otago School of Pharmacy BPharm program between 2008 and 2012, from a preceding health science year (HSFY). Preadmission baseline data including health science grade point average (GPA), sex, age, ethnicity, residency status, and high school qualifications were matched against outputs of GPA performances in all three years of the BPharm program using regression analyses.

High dose dry powder inhalers to overcome the challenges of tuberculosis treatment.

Tuberculosis (TB) is a major global health burden. The emergence of the human immunodeficiency virus (HIV) epidemic and drug resistance has complicated global TB control. Pulmonary delivery of drugs using dry powder inhalers (DPI) is an emerging approach to treat TB.

Temperature Resistant Binary SLES/Nonionic Surfactant Mixtures at the Air/Water Interface.

Surface compositions of adsorbed monolayers at the air/water interface, formed from binary surfactant mixtures in equilibrium, have been studied using neutron reflectivity at three discrete temperatures: 10, 25, and 40 °C. The binary compositions studied are sodium lauryl dodecyl ether sulfate (SLES EO3)/C12E n, where n = 6 and 8, at a fixed concentration of 2 mM with and without the addition of 0.1 M NaCl.

How do mental health services respond when child abuse or neglect become known? A literature review.

Child abuse and neglect are strongly associated with many subsequent mental health problems. This review summarizes the research on how adult mental health services respond when child abuse or neglect become known. MEDLINE, PsycINFO, and Scopus were searched for studies with rates of responding in various ways to child abuse and neglect by mental health professionals.

Manipulation of spray-drying conditions to develop dry powder particles with surfaces enriched in hydrophobic material to achieve high aerosolization of a hygroscopic drug.

This study aimed to develop dry powder particles with surfaces enriched in hydrophobic material by manipulation of spray-drying conditions and to investigate the effect of hydrophobic surface enrichment on aerosolization of hygroscopic drug. The composite dry powder formulations of kanamycin (hygroscopic drug) and rifampicin (hydrophobic drug) were produced by systematically (2 full factorial design) varying the drug ratio, co-solvent composition and inlet temperature using Buchi B-290 Mini Spray-Dryer. All the composite powder particles were inhalable in size (3.