Publications by authors named "Ian Sanchez"
Prenatal arsenic exposure is a major public health concern, associated with altered birth outcomes and increased respiratory disease risk. However, characterization of the long-term effects of mid-pregnancy (second trimester) arsenic exposure on multiple organ systems is scant. This study aimed to characterize the long-term impact of mid-pregnancy inorganic arsenic exposure on the lung, heart, and immune system, including infectious disease response using the C57BL/6 mouse model.
View Article and Find Full Text PDFObjective: We investigated the effects of chronic waterpipe (WP) smoke on pulmonary function and immune response in a murine model using a research-grade WP and the effects of acute exposure on the regulation of immediate-early genes (IEGs).
Methods: WP smoke was generated using three WP smoke puffing regimens based on the Beirut regimen. WP smoke samples generated under these puffing regimens were quantified for nicotine concentration.
Article Synopsis
- The study investigated how a high fat diet (HFD) influences airway hyperresponsiveness (AHR) in mice, comparing results with a regular chow diet over two weeks.
- While body weight increased by 11% on HFD, it did not change baseline respiratory resistance but significantly heightened airway responses to methacholine, with a notable 40.5% increase at the highest concentration.
- The HFD led to a substantial increase in IL-1β expression and secretion in lung tissue, indicating a link between high fat intake and inflammatory responses in the airways, despite no changes in bronchoalveolar lavage or other measured factors.