Publications by authors named "Ian R Fleming"

The biochemical methane potential (BMP) test is significant for the landfill industry as it provides a means to evaluate the gas potential, and therefore potential degradability, of both incoming and in-place municipal solid waste (MSW). However, the BMP test is not standardized making comparison of BMP results across sites problematic. For example, the BMP test duration has historically ranged from 20 days to several months with most current BMP tests lasting 60 days.

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Ras family GTPases (H/K/N-Ras) modulate numerous effectors, including the lipid kinase PI3K (phosphatidylinositol-3-kinase) that generates growth signal lipid PIP (phosphatidylinositol-3,4,5-triphosphate). Active GTP-Ras binds PI3K with high affinity, thereby stimulating PIP production. We hypothesize the affinity of this binding interaction could be significantly increased or decreased by Ras mutations at PI3K contact positions, with clinical implications since some Ras mutations at PI3K contact positions are disease-linked.

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