Publications by authors named "Ian Mcadams"

Article Synopsis
  • Continuous sacral neuromodulation (SNM) effectively treats overactive bladder by reducing leakage and increasing storage capacity, while conditional SNM adapts stimulation based on bladder conditions.
  • A study using a wireless bladder pressure sensor and the Medtronic Summit RC+S system tested four conditional SNM methods over five days on four female sheep, aiming to prove the effectiveness of a closed-loop system.
  • Results showed that the neurostimulator successfully executed stimulation commands rapidly, and while there was weak correlation with catheter-based pressure measurements, the system could still accurately trigger SNM, indicating potential for personalized treatment in future human applications.
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New research and diagnosis tools are needed to continuously measure bowel state and activity. We investigated functionality of several sensors in vivo and in vitro. Five sensor types, including pressure, infrared, color, conductivity and capacitance, were tested to validate functionality inside the colon.

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New research tools are essential to help understand the neural control of the lower urinary tract (LUT). A more nuanced understanding of the neuroanatomy of bladder function could enable new treatment options or neuroprosthesis to eliminate incontinence. Here we describe the design, prototyping and validation of a sensing mechanism for a catheter-free fluid volume estimating system for chronic neurophysiological studies of the lower urinary tract and ambulatory urodynamics.

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The role of peripheral nerves in regulating major organ function in health and disease is not well understood. Elucidating the relationships between biomarkers and neural activity during conditions free form anesthesia is essential to advancing future investigations of autonomic organ control and improving precision for neuromodulation treatment approaches. Here we present a simple, customizable, off-the-shelf component sensor platform to meet research needs for studying different organs under conscious, free movement.

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