Publications by authors named "Ian M Heger"
Article Synopsis
- Recurrent brain tumors are a major cause of cancer-related deaths in children, and the study focused on indoximod, which inhibits a metabolic checkpoint called IDO and may enhance anti-tumor immunity post-chemotherapy.
- A phase I trial was conducted with 81 pediatric patients, using indoximod in combination with temozolomide or radiation, to assess its safety and determine the appropriate dosage.
- Results showed a median overall survival of 13.3 months for recurrent cases, with patients who responded to treatment experiencing significantly longer survival, and the findings indicate potential for further trials to evaluate indoximod's effectiveness in treating pediatric brain tumors.
Optic nerve sheath diameter (ONSD) is used clinically as a noninvasive measure for elevated intracranial pressure (ICP). This study had two purposes: to investigate the immediate effects optic nerve sheath (ONS) dilation post-ICP increase on trabecular fibers connecting the optic nerve to the ONS and to document any changes in these fibers 30 days post-increased ICP. In a swine model, ICP was increased by inflating a Foley catheter balloon in the epidural space.
View Article and Find Full Text PDFObjective: Occipitocervical fusions in the pediatric population are rare but can be challenging because of the smaller anatomy. The procedure is even more exacting in patients with prior suboccipital craniectomy. A proposed method for occipitocervical fusion in such patients is the use of occipital condyle screws.
View Article and Find Full Text PDFVenous air embolism (VAE) is a potential complication during cranial vault remodeling requiring early detection and prompt therapeutic intervention. The incidence of VAE has been reported to be as high as 82.6% during open craniectomy for craniosynostosis repair.
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