Publications by authors named "Ian J Bishop"
Re-Evaluating the Association Between Hormonal Contraception and Breast Cancer Risk.
Breast Cancer (Dove Med Press)
March 2023
Article Synopsis
- This review summarizes studies on hormonal contraception and its potential link to breast cancer risk, highlighting that long-term estrogen exposure is a debated factor.
- Key hormonal contraception methods—including oral, transdermal, and transvaginal—are assessed for associated risks, with gaps in current knowledge emphasized.
- Challenges in research include accounting for established risk factors, determining causes of associations, and differentiating between statistical and clinical significance, which are crucial for guiding women's healthcare decisions.
Objective: To compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm.
Study Design: Sub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples.
Results: Plasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.
Objectives: To evaluate whether etonogestrel concentrations are reduced to a level that could potentially reduce contraceptive efficacy when the etonogestrel contraceptive implant is used concomitantly with dolutegravir-based antiretroviral therapy (ART).
Study Design: We conducted a non-randomized, open-label, cross-sectional pharmacokinetic study among women using single-rod etonogestrel contraceptive implants in Botswana. We compared plasma etonogestrel concentrations, sampled at a single time-point between 3 and 12 months from implant insertion, among implant users living with HIV and receiving dolutegravir-based ART with HIV-negative implant users.