Publications by authors named "Ian Herron"
Animal models of infectious disease often serve a crucial purpose in obtaining licensure of therapeutics and medical countermeasures, particularly in situations where human trials are not feasible, i.e., for those diseases that occur infrequently in the human population.
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- The study investigates Pim-1, a protein linked to cancer and autoimmunity, as a potential therapeutic target for early rheumatoid arthritis (RA).
- Researchers developed a flow cytometry assay to measure Pim-1 activity in patients with early RA and discovered that Pim-1 levels were significantly higher in these patients compared to others.
- Inhibiting Pim kinases in CD4+ T cells reduced their activation and inflammatory cytokine production, and also demonstrated promising results in limiting arthritis progression in animal models, suggesting that Pim inhibitors could be repurposed for treating early RA.