Publications by authors named "Ian Copeland"
Childhood-onset essential hypertension (COEH) is an uncommon form of hypertension that manifests in childhood or adolescence and, in the United States, disproportionately affects children of African ancestry. The etiology of COEH is unknown, but its childhood onset, low prevalence, high heritability, and skewed ancestral demography suggest the potential to identify rare genetic variation segregating in a Mendelian manner among affected individuals and thereby implicate genes important to disease pathogenesis. However, no COEH genes have been reported to date.
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- Irritable Bowel Syndrome (IBS) involves abdominal pain and changes in bowel habits, such as constipation, diarrhea, or both, and is linked to malabsorption of carbohydrates.
- Research has identified several common genetic variants in digestive enzymes associated with IBS symptoms through candidate gene studies.
- Additionally, rare genetic variations may contribute to certain IBS cases, suggesting a genetic basis for moderate to severe gastrointestinal symptoms in these individuals.