Publications by authors named "Ian C Bowater"
Article Synopsis
- The study analyzes the effects of halofantrine (Hf) on soybean oil fat emulsions, noting that Hf increases the zeta potential and shifts the isoelectric point to higher pH values.
- Despite initially destabilizing the emulsion at low Hf concentrations, higher amounts of Hf help maintain stability, as shown by changes in particle size and polydispersity.
- To ensure the emulsions remain stable, it's essential to keep the pH away from the isoelectric point and maintain a higher concentration of halofantrine.
We report on the successful incorporation of the antimalarial drug, halofantrine, into laboratory based soybean oil emulsions which were designed to mimic the commercially available parenteral fat emulsion, Intralipid. A high pH (minimum of pH 9, preferable pH of 11) was required for the drug laden emulsion to remain stable on storage and also to resist breaking under various stresses. Ageing of lecithin samples on storage was noted to result in degradation and a decrease in pH.
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