Resilience Factors in Reentry From Juvenile Legal Facility Settings: A Scoping Review.

Internationally, there has been a decline in the use of juvenile legal facilities (Puzzanchera et al., 2022). Yet, it is well documented that the process of reentering the community following placement in these settings presents numerous challenges for young people.

Evolution of antibiotic cross-resistance and collateral sensitivity in using the mutant prevention concentration and the mutant selection window.

In bacteria, evolution of resistance to one antibiotic is frequently associated with increased resistance (cross-resistance) or increased susceptibility (collateral sensitivity) to other antibiotics. Cross-resistance and collateral sensitivity are typically evaluated at the minimum inhibitory concentration (MIC). However, these susceptibility changes are not well characterized with respect to the mutant prevention concentration (MPC), the antibiotic concentration that prevents a single-step mutation from occurring.

The crystal structure of superoxide dismutase from Plasmodium falciparum.

Background: Superoxide dismutases (SODs) are important enzymes in defence against oxidative stress. In Plasmodium falciparum, they may be expected to have special significance since part of the parasite life cycle is spent in red blood cells where the formation of reactive oxygen species is likely to be promoted by the products of haemoglobin breakdown. Thus, inhibitors of P.

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum.

Plasmodium falciparum possesses a single mitochondrion with a functional electron transport chain. During respiration, reactive oxygen species are generated that need to be removed to protect the organelle from oxidative damage. In the absence of catalase and glutathione peroxidase, the parasites rely primarily on peroxiredoxin-linked systems for protection.

Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.

The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B.