[Effects of iron ion additional introduction in radiation therapy of tumor-bearing animals].

The gender differences of the transplantable glioma-35 growth were revealed in tumor-bearing rats. The effect of mineral iron containing water (ICW) as drinking water was studied during radiation therapy (RT) in tumor bearing male rats. It was shown that ICW used separately had a weak anti cancer effect.

[The influence of circadian rhythms of geomagnetic field variations and the background cosmic radiation on nitric oxide production in human organism].

The circadian rhythms of background gamma-radiation and Ki-indexes of geomagnetic activity (GMF) during August-September 2008, January-February 2010 and March 2011 were studied. The authors show that in summer period the maximum of Ki-indexes and gamma-radiation were at 3 p.m.

[The age aspects of geomagnetic field action on the human].

The quantity of information about the influence of geomagnetic field (GMF) on human health increases. However, the age aspects of such influence still are of little studied. Earlier we suggested that GMF influence on reactions with such free radicals as nitric oxide (NO).

[Effect of additional administration of ferric ion on the life span of irradiated animals].

There were established regularity of early biological reactions, restoration and life span shortening in rats after gamma-irradiation of animals with low (25 and 50 cGy) or 600 cGy doses in combination with various regimen of ferric ions introduction with drinking water (60-63 mg/l).

[The influence of ferromagnetic screening from natural electromagnetic fields on the hematological and toxicogenomic indexes in animals].

The aim of the study was to reveal during 45 days consequences of ferromagnetic screening (FS) on the hematological and toxicogenomic indexes in rats. An express-method of nucleiod DNA content in blood by help fluorescent indication was used for alive quantitative evaluation of the toxicogenomic effects. The FS for both gender rats during 48 hrs resulted in both decreased magnetic field by 4-10 microT1 and leucopenia by 14 day of experiment.

[Age diseases depending on geomagnetic field activity inside the womb period].

Between age diseases two are standing out: oncological and cardiovascular ones. They give a main contribution to mortality of the population. Those who avoid these diseases have a chance to live longer.

[Effect of additional administration of iron ions on the efficacy of radiotherapy of glioma-bearing animals].

Our analysis failed to establish any antitumor effect of treatment of rats with transplantable glioma-35 with iron-containing mineral drinking water (ICMW). The latter treatment combined with irradiation (15 Gy) was followed by enhanced genotoxic effect in white blood cells. Post-irradiation administration of ICMW did not influence glioma growth significantly as compared with radiation alone.

[The evolutionary role of nitric oxide in circadian activity and defense of the organism from cosmic rays].

The cosmic rays are one of the constantly acting factors influencing on genetic apparatus and depending from sun activity, which have the circadian rhythm. The nature creates a number of mechanisms, which defend the organism from cosmic rays and free radicals as consequence. However, the malfunctions of these mechanisms damage the genetic apparatus, accelerate the aging and bring to a number of illnesses.

[Prediction of relapse-free period after radio- and chemotherapy in patients with breast cancer].

The study was carried out in 55 females with breast cancer stage III-IV, aged 35-77 yrs. The patients received radiation and standard courses of CMF, or CAF, or CMF+trastuzumab, or carboplatin+vepesid, or taxotere+epirubicin, or mustoforan. Radiation was administered in fractionated single focal doses of 3 Gy.

[Effect of geomagnetic field on leukocyte count in cancer patients. Role of nitric oxide].

Relationships were studied between leukocyte and neutrophil levels in patients with breast, bladder tumors and Hodgkin's disease and in healthy subjects, on the one hand, and geomagnetic field (GMF) status on the day before blood sampling, on the other. In breast and bladder cancer patients, both total leukocyte and absolute neutrophil counts increased when GMF was high. In the Hodgkin's disease group, that correlation was reversed.

[The influence of geomagnetic variations on the formation of nitric oxide in exhaled air in human].

The content of nitric oxide in exhaled air in healthy persons has been studied. It was shown that nitric oxide in exhaled air is formed from saliva nitrite due to the nitrite reductase activity of mouth cavity microflora. A relationship between the nitric oxide level and age, arterial pressure, and geomagnetic field indices was established.

[Geomagnetic field variations in the human prenatal period and cancer in adults].

Our earlier evidence pointed to a relationship between geomagnetic field (GMF) variations in pre- and early postnatal periods and appearance in the future of oncopathology in these patients. It appears to contribute to risk for such malignancies in adults as breast, lung, liver, bladder, kidney, prostate, hypophysis cancer, ovarian carcinoma, skin melanoma, Hodgkin's disease, lymphoma, and probably stomach cancer. No link was detected between esophageal, thyroid, colorectal cancer or cervical carcinoma, on the one hand, and GMF variations in prenatal period, on the other.

[Smoking affects metal-ecotoxicant accumulation and genotoxic reactions in leukocytes].

The investigation was concerned with the influence of smoking on manganese (Mn), lead (Pb) and cadmium (Cd) content in the blood of metropolitan groups of varying age as well as on genotoxic reactions in leukocytes after test irradiation ex vivo. The study involved 325 inhabitants of St.Petersburg, aged 10-90 years.

[Prognosis of efficacy of organ-saving treatment of invasive bladder cancer].

It is suggested that Scr-index for radiation-induced apoptosis in leukocytes in vitro be determined prior to combined therapy of urinary bladder cancer in order to estimate its efficacy. It was identified by studying leukocytes of peripheral blood from patients in whony white blood cells DNA level decreased after exposure to 2 Gy and 3-hr incubation at 37 degrees C. Values over 1.

[Pre- and early natal exposure to geomagnetic field as risk for melanoma and basal cell skin tumors].

Histories of 173 male and female patients with melanoma and basal cell skin tumors (BCST) were followed to elucidate the influence of pre- and early natal exposure to geomagnetic field (GMF) on future incidence of cancer. A positive correlation was established between exposure to GMF during critical months of prenatal period, on the one hand, and melanoma detection, on the other. However, a similar correlation involving BCST was inverse which suggests a difference in the etiologies.

[Influence of cultivation conditions on bacterial DNA content and bacterial membrane permeability].

The study included measurement of intracellular and extracellular DNA content and evaluation of bacterial membrane condition during plankton growth and in isolated communities. This was performed at different stages of bacterial development and after heating at the temperature of heat shock system activation. The content of intracellular bacterial DNA in the community decreased after 72 hours of cultivation growth more prominently than during plankton growth.

[The hemathological reactions in rats after partial screening from natural electromagnetic fields].

The influence of partial screening of EMF on the composition of white blood cells was studied in the experiments on rats. Two kinds of copper rings were used in these experiments: individual for each rat and common for the cage. It was shown that inside the ring the composition of blood cells was changed--in 3-5 hours the number of granulocytes increased and in 24 hours it restored to the initial level.

[Vilon effect on consequences of repeated radioactive and mercuric impact in small doses].

The purpose of the study was to determine the efficacy of vilon administration in rats after reiterated exposure to ecotoxicants (mercury in concentration near to maximum allowable one and gamma-radiation in small dose). In 24 hours after repeated radioactive and mercuric impact (RMI) and for 30 consecutive days the animals reported lymphopenia. At the same time the indices of DNA leucocytes content and structure did not differ from the parameters of intact animals, this could evidence the development of adaptation reactions.

[Geomagnetic field variation in early ontogenesis as a risk factor for oncopathology].

The data on 534 cancer patients with tumors of 15 different sites were evaluated to elucidate the influence of geomagnetic field (GMF) in certain months of the pre- and early postnatal periods on future incidence of cancer. We identified neoplasms of the breast, lung, urinary bladder, hypophysis, ovary, prostate, liver, Hodgkin's disease, lymphoma and, possibly, gastric cancer as GMF-dependent. This relationship appeared to be idiosyncratic with every cancer variety.

[Prognostication of hematotoxicity for radio- and chemotherapy in patients with breast cancer].

The effectiveness of radiation and chemotherapy for breast cancer depends on individual response to drug-induced toxicity. The response can be evaluated by means of myelodepression. To this end, changes in leukocyte DNA level after ex vivo gamma radiation test were used as a criterion.

[The influence of geomagnetic field on blood leukocyte radiosensitivity and gender determination in humans].

The gender and age features of the geomagnetic field (GMF) influence (K-indexes) on the leukocyte radiosensitivity (S) in human blood in case of normal and enhanced levels of metal-ecotoxicants (Pb, Cd, Hg, Mn, Zn, Cu) in blood was studied, as well as the impact of the GMF intensity alterations on the child gender determination. In the whole studied population (n = 244) it was observed a negative relationship between S- and K-indexes. It was shown that the most changes of blood leukocyte radiosensitivity depended on the GMF oscillations in men older than 45 years.

[The use of cycloferon in experimental radiotherapy of tumors].

The biological activity of cycloferon (CF) used in interferon manufacture has been investigated for its therapeutic and prophylactic properties which may be used for radiotherapy of glioma. It was demonstrated in experiments on rats that use of CF is most effective at an early stage of irradiation due to decrease in tumor mass which does not occur in case of irradiation alone. When used at a later stage, CF caused certain hematological indices of immunity to rise.

[Benz(a)pyrenes and N-nitrosamines in dry dairy products].

Results of works induding study of effect of different factors (environment, type of equipment, technology) on content of cancerogenic substances in dry milk products were summarized. Possible reasons of appearance of cancerogens in milk in process of drying were determined, dataes of concentration of benz(a)pyren and N-nytrozamens in milk and warmth carrier before and after drying were established. Explanation of separate appearances which connect with change of quantity of cancerogens in product on different stages of drying was suggested.