[The results of proton radiosurgery for pituitary endosellar adenomas].

465 patients with pituitary endosellar adenomas have passed irradiation on the synchrocyclotron PNPI (1000 MeV). Due to the high energy of the proton beam the rotating-convergent shoot-through technique was used. The single dose of 80-100 Gy was given.

[Proton irradiation of the pituitary gland for alleviating pain in patients with disseminated prostate cancer].

Central Research Institute of Roentgeno-Radiology; Medical Academy for Further Education, St. Petersburg Stereotactic ablation of the frontal lobe of the pituitary with narrow beams of 1,000 MeV protons was performed in 80 patients to alleviate pain caused by bone metastases. Pain was aborted for a long time so that pain-relieving medication was suspended in 56 (70%) patients.

[Proton stereotaxic therapy of epilepsy due to cerebral arteriovenous aneurysms].

The authors estimated the influence of proton-beam stereotaxic therapy on a course of epileptic fits in cerebral arteriovenous aneurysms (AVA). A stable disappearance of epileptic fits was noted in 16 of 29 patients (56%), in 12 of them (41%) positive angiography results were noted. The calculated D and V fields of irradiation for 16 patients without fits and for 13 patients with epileptic fits after proton-beam stereotaxic therapy have shown that with D being the same, the effect depends upon a fraction of an AVA irradiated area.

[Proton stereotaxic therapy of arteriovenous aneurysms of the brain].

The paper is concerned with analysis of angiographic findings on 62 patients with arteriovenous aneurysms (AVA) of the cerebral vessels who received proton beam stereotactic therapy in the period of 1978-1986 depending on an absorbed dose value of an irradiated volume. Proton stereotactic therapy (PST) of brain AVA located deep in the functionally important regions, can be used as an independent radical therapeutic method in such cases including inoperable ones. Complete AVA elimination from the blood flow or considerable reduction of the AVA volume was achieved in 68% of the patients after delivering a dose of approximately 40 Gy, the AVA volume being approximately 30%.

[Proton stereotaxic therapy of cerebral arteriovenous aneurysms].

Stereotaxic proton beam therapy using narrow beams (5-10 mm at 50% of isodose) at the energy of 100 MeV in single irradiation and the delivery of absorbed doses, the maximum dosage being 40-80 Gy, was provided to 99 patients with arteriovenous brain aneurysms. An analysis of the therapeutic results based on angiography data was performed in 50 patients with arteriovenous malformations with the volume up to 10 cm3. A positive effect was obtained in 31 of 50 patients.