[Use of metformin (siofor) in patients with gout and insulin resistance (pilot 6-month results)].

Aim: To evaluate metformin efficacy and safety in patients with gout and insulin resistance (IR).

Material And Methods: The trial included 26 patients with gout (criteria of the American collage of rheumatologists) and IR (index HOMA). The inclusion criteria were the following: absence of antigout therapy, normal hepatic and renal function, rejection of alcohol.

[Markers of vascular endothelium activation in gout].

Aim: To determine clinical significance of laboratory markers of vascular endothelium activation in gout.

Material And Methods: A total of 16 males aged 31-68 years with gout entered the study. The diagnosis satisfied Vallas' criteria, duration of the disease varied from 1.

[Severity of a female gout course].

Aim: Comparison of a gout course in males and females.

Material And Methods: The trial enrolled 34 patients (17 females and 17 males). The patients were matched by age and the disease duration.

[The effectiveness and safety of nimesulide (nimesile) in patients with gouty arthritis].

Patients with gout are at a high risk for drug-induced complications associated with the use of nonsteroidal anti-inflammatory drugs due to the baseline renal and hepatic abnormalities, metabolic disturbances, and concomitant diseases, such as arterial hypertension or type 2 diabetes mellitus. In this connection, it is expedient to use safer selective cycloxygenase-2 (COG-2) inhibitors. However, there are only single reports dealing with studies of the effectiveness and safety of selective COG-2 inhibitors in gout.

[Detection of sodium monourate crystals in biopsies of gastric mucosa in patients with gout].

Aim: To examine gastric biopsies with polarization microscopy for detection of sodium monourate crystals (SMC).

Material And Methods: The trial included 20 patients with gout diagnosis (mean age 55.7 years, mean duration of the disease 12.

[Insulin resistance syndrome in patients with gout and its influence on formation of clinical characteristics of the disease].

Aim: To evaluate the occurrence of immunoresistance (IR) syndrome in gout and its correlation with a gout course.

Material And Methods: Anthropometric parameters, blood lipid spectrum, levels of glucose, uric acid (UA), immunoreactive insulin, HOMA index were studied in 55 male patients with gout (mean age 50.1 +/- 7.

[Nimesil treatment of gouty arthritis].

Aim: To evaluate efficacy and safety of nimesil, a selective inhibitor of cyclooxigenase-2, in gouty arthritis (GA).

Material And Methods: Nimesil was given to 20 male patients with GA (mean age 53.8 years, mean duration of the disease 8.