Duropathy as a rare motor neuron disease mimic: from bibrachial amyotrophy to infratentorial superficial siderosis.

Background: Bibrachial amyotrophy associated with an extradural CSF collection and infratentorial superficial siderosis (SS) are rare conditions that may occasionally mimic ALS. Both disorders are assumed to be due to dural tears.

Case Presentation: A 53-year-old man presented with a 7-year history of slowly progressive asymmetric bibrachial amyotrophy.

SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis.

Oncofetal transcription factor SALL4 is essential for cancer cell survival. Recently, several groups reported that immunomodulatory imide drugs (IMiDs) could degrade SALL4 in a proteasome-dependent manner. Intriguingly, we observed that IMiDs had no effect on SALL4-positive cancer cells.

A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes.

Unlabelled: Unfortunately, available liver cancer treatments are associated with modest survival advantage. The biggest factor improving survival is early detection, but the current understanding of early transformation events is limited. Therefore, we set up a model to study these early events and investigated the relationship of premalignant, senescent hepatocytes, a regenerative environment, and the influence of secreted factors on liver tumorigenesis.

Relation of sensorimotor and cognitive cerebellum functional connectivity with brain structural damage in patients with multiple sclerosis and no disability.

Background And Purpose: To investigate the relationship between the functional connectivity (FC) of the sensorimotor and cognitive cerebellum and measures of structural damage in patients with multiple sclerosis (MS) and no physical disability.

Methods: We selected 144 relapsing-remitting MS patients with an Expanded Disability Status Scale score of ≤1.5 and 98 healthy controls from the Italian Neuroimaging Network Initiative database.

[Salicylate-induced modification of plant proteomes (review)].

Here we present a brief review of the reports concerning proteome modifications under the influence of salicylic acid, which is one of the major mediators of both local and systemic immunity. We describe also the results of our own studies of the salicylate-induced changes in proteomes of pea leaves and roots. Fifteen salicylate-inducible proteins, which were previously unknown, have been identified.

[Use of atomic force microscopy to study the cytomorphological signs of papillomavirus infection].

The paper presents the results of studying genital squamous epitheliocytes from human papillomavirus-infected female patients by cytology and atomic force microscopy. The squamous epitheliocytes with and without cytomorphological signs of papillomavirus infection (koilocytosis, dyskeratosis, parakeratosis, hyperkeratosis) have been compared. Examining the surface of the squamous epithelium has yielded quantitative characteristics of infection-induced surface changes.

[Estimation of doses of irradiation with radon-222 and its degradation products in adults of Tomsk].

The paper presents the results of statistical processing of experimental data on the volumetric activity of radon within the premises of various buildings. The results were used to estimate internal radiation doses of inhaled radon and its short-lived degradation products in the population of Tomsk. The average annual population-weighed value of the effective dose was 1.

[Characteristics of caries and parodontal diseases in young men with constitutionally determined nutrition insufficiency].

151 young men with constitutionally determined nutrition insufficiency were examined. For absolute majority of them multiple caries with primary lesions development in incisors and on 3 molar surfaces was typical. In patients with constitutionally determined nutrition insufficiency caries complications with predominance of acute apical or chronic periodontitis were 3 times more often diagnosed.

[Possibility of development of oral and tissues diseases in young men with constitutional nutrition insufficiency].

Thorough examination of 114 young men of pre-constriction military training age disclosed that possibility of oral cavity pathology development is mainly determined by the indices DMFT, PMA, OHI-S and the following parameters of mixed saliva -- basic salivary flow, pH and Lactobacillus and Streptococcus mutans amounts. The degree of these factors changes expressed in scores identifies groups of low, medium and high probability of stomatologic pathology development and basing on this to individualize curative and preventive measures.

[Factors determining the formation of radon levels inside buildings].

The theoretical and experimental investigation of radon levels inside dwellings of Tomsk was carried out. The statistical analysis of gathered results let us to reveal the significant factors, which define the formation of radon levels inside the buildings and dependencies of radon distribution. The significant factors are: building type (urban or rural), year season, floor level (is significant only for buildings of rural type), daytime and social factor includes habits and life stile of inhabitants.

[Stomatologic diseases in young men with constitutionally related malnutrition].

The stomatologic investigation has revealed multiple caries in the youths of pre-conscription age with constitutionally conditioned malnutrition (CCM). Its specific features are the following: the high affection of incisor and molar teeth, the involvement as a rule of 3 dental surfaces, the high incidence of complicated caries (especially when the bode mass index is 16.69 + /- 0.

[Radiation doses in children of the Tomsk region during inhalation of radon-222].

The paper presents the results of the studies of the levels of radon in the premises of 30 kindergartens and 36 schools of Tomsk and its region, which were conducted in 1989 to 2000. The volume activity of radon in the air of the premises was measured by using passive track detectors of gamma-radiation upon a long-term exposure of 1-3 months. In parallel with these measurements, statistical data required for a more accurate assessment of effective doses were collected.

[Criteria for the assessment of radon potential risk in territories].

The detailed analysis of criteria used in the different countries for an assessment of radon potential risk in territories was made. Such criteria as radon flux density from earth surface, radon concentration in soil air, specific activity of 226Ra in superficial soils were chosen. The analysis has revealed that the most reliable criterion is the value of equilibrium radon concentration in the soil air.

[In vitro induced activity of polymorphonuclear leukocyte myeloperoxidase at different stages of opisthorchis invasion and at stages of a different rehabilitative period].

Polymorphonuclear leukocytes from 115 patients with opisthrochiasis at its different (acute and chronic) stages were studied before and 1-3 days, 1-3 months, and 1-2 years after antihelminthic therapy with bilthricide. The functional activity of the cells in question was evaluated following an hour load with different drugs: bilthricide, ascorbic acid, decaris, cyclophosphane, doxycycline in a final concentration of 2.5 x 10(-5) mole/l.

[Increase of lysosomal cationic proteins of polymorphonuclear leukocytes as a response to opisthorchis invasion].

Cytochemistry was used to study the level of lysosomal cationic proteins of polymorphonuclear peripheral leukocytes in 25 and 20 patients with acute and chronic opisthorchiasis, respectively, before treatment. Comparison groups included patients with chronic viral hepatitis C, bronchial asthma, as well as apparently healthy individuals free of Opisthorchis invasion. That the ratios of an increase in the intracellular content of lysosomal cationic proteins to that in the control individuals were found to be 13.

[Adaptability of Opisthorchis felineus metacercariae as a result of altered phagocytic activity of polymorphonuclear neutrophils].

The higher absorptivity of neutrophils during their alpha-tocopherol stimulation has been found to promote lower adaptability in the metacercariae of Opisthorchis felineus, a reverse picture was observed when cyclophosphanum was used. The antihelminthic effect of biltricide is probably to be unassociated with the changed functional activity of polymorphonuclear leukocytes, but to be determined by its direct action on helminths. This phenomenon was studied on golden hamsters inoculated with Opisthorchis felineus.

[The assessment of the impact of different radon sources into indoor air].

The contributions of different radon sources into total indoor radon level can differ in some times depending on geographical and climatic features of the locality, building characteristics, lifestyle and habits of the population. The revealing of most significant radon sources for examined locality and the assessment of their relative contributions will allow planning expected radon levels during building design stage. The analysis of the factors influencing indoor radon levels and the computation of radon enter to dwellings from different sources were carried out in Tomsk.

[Role of the number of stories in the radiation-sanitary assessment of residential buildings].

Upon long-term exposure, the radioactive gas radon-222 and its decay products in increased doses adversely affect human health. Since the human being spends about 65% of his time in the buildings, it is necessary to evaluate air radiation purity in the rooms, which can be obtained by making a sanitary radiological survey of residential buildings. The scope of the rooms in many-storeyed buildings to be examined can be considerably reduced if the regularities in radon distribution are known.

[Immunological status and its changes in children during surgery on anterior eye segment].

Nonspecific and specific immunity values were studied in 70 children before and in various periods after 74 operations on the anterior segment of the eyeball. In children with persistent autosensitization to ocular tissue autoantigens (alpha-crystalline and S-antigen) postoperative uveitis presented as an immunocomplex disease with signs of exhaustion of the functional potential of the phagocytosis and complement systems. In children without autosensitization uveitis was associated with immunity activation.

[The myeloperoxidase of the polymorphonuclear leukocytes as a marker of the stage of Opisthorchis invasion and as an indicator of the efficacy of chemotherapy].

A total of 152 patients with Opisthorchis infection at the acute and chronic stage of the diseases, as well as 1-3 days and 1-2 months after therapy with biltricide in a dose of 60 mg/kg body weight. Intracellular myeloperoxidase was spectrophotometrically determined. Its activity was demonstrated to be significantly varying at the different opisthorchiasis stage.

[Secretory and immunocompetent functions of the parotid and submaxillary salivary glands after thymectomy].

The dynamics of morphological, enzymatic and immunologic salivary glands indices in pubertal rates was investigated after thymectomy. The data obtained analysis demonstrated the functional salivary glands reconstruction, having immunologic and secretory characteristics: stimulation of the humoral and cellular immunity factors; reduction of the albuminous and rise of the mucous salivary glands component represented the remote effect of thymectomy /3 months]. Activation of the salivary glands immune characteristics may be explained by their belonging to the thymic-peripharyngeal complex.

[Experience in the surgical treatment of chronic suppurative lung disease in children].

Unlabelled: Operations were performed on 750 children with cystic hypoplasia and dysontogenetic and acquired bronchiectases. The operation volume: pulmonectomy, lobectomy, combined resections, resection of pulmonary tissue with extirpation of bronchi, extirpation of bronchi.

Complications: atelectasis, pneumonia, intrapleural hemorrhage were encountered in 87 (11.