Publications by authors named "Iakovleva S"

Peculiarities of military occupational activities are repeated stress and high degree of psychoemotional strain. The article deals with results of momentary study covering a select from military men cohort, with thyroid tests, renal functional tests, diurnal monitoring of blood pressure and psychologic state assessment. Course of arterial hypertension in military men subjected to chronic stress presents prevailing systolic-diastolic and diastolic variants with excessive decrease of blood pressure at night, with high values of albuminuria.

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The paper presents the results of follow-up of 11 patients with Parkinson's disease (PD) after neurotransplantation (NT) of fetal brain dopaminergic suspension into the caudatus and putamen on one or two sides. All the patients were clinically assessed at least 3 months before and during a follow-up (for as long as 9 years) in accordance with the Core Assessment Program for Intracranial Transplantation (CAPIT) by a Russian group of the Network of European CNS Transplantation and Restoration (NECTAR) Programme by using the Unified Parkinson's Disease Rating Scale (URDRS). An analysis of clinical findings showed that: 1) there was a slight amelioration in bradykinesia, rigidity, and smaller dosage of L-DOPA; 2) tremor and drug-induced dyskinesia remained unchanged; 3) subsequently (till 9 years), the clinical effect slightly decreased in almost all patients with PD and in some of them the clinical status became worse than that prior to surgery; 4) repeated NT (2 cases) in the striatum contralaterally did not improved the situation; 5) only neurostimulation of subcortical structures improved clinical results.

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Aim: To show that the activity of a multiple myeloma (MM) course, its sensitivity to chemotherapy and prognosis correlate with maturity of medullary plasma cells (MPC).

Material And Methods: Bone marrow films from 88 primary MM patients. The films were stained by Romanovsky-Giemsa and studied by the immersion objective.

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Serum levels of lactate dehydrogenase (LDG) and beta 2-microglobulin (beta 2-MG) were measured in 164 and 128 patients with multiple myeloma (MM), respectively. High levels of LDG were recordable in 15.4% of patients at diagnosis and 36.

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A crystallization method was proposed to assess disturbances in the lipid system; it was based on the interaction of a serum lipid fraction with a lecithin matrix. A total of 255 invidividuals were examined. A model experiment was performed by using chemically pure cholesterol (96 samples) and 10 different cholesterol esters (240 samples).

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A diagnostic agent for enzyme immunoassay of ceruloplasmin has been developed. The method is highly sensitive and specific. The minimal detectable amount of ceruloplasmin is 25 ng/ml, variance coefficients with 1 lot being 2.

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Photooptical response, both of the whole blood and of its non-pigmented fraction-plasma to the low-intensity red light is investigated. For the case of the blood irradiation in vitro it is shown that the mechanism of the low-intensity red light effect on the blood is not directly associated with the pigmented molecular complexes concentrated in erythrocytes. Thus the effect of the low-intensity red light on living organisms includes the mechanisms not using light absorption by the specialized macromolecule--photoreceptor as a primary photophysical action.

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Rabbit tissue fluid at different stages of wound healing was studied. Interaction between the formation of liquid crystalline fractions and the course of healing was revealed both under natural conditions and under periodic laser irradiation of the wound.

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It was established that localized exposure of an inflammatory focus to laser radiation causes, besides the well-known effect on biochemical activity, structural photophysical reorganization of the liquid crystalline complexes not only in the irradiated tissues but also in parts of the organism situated at a distance from the exposed area.

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Liquid-crystalline structure formation in glycoprotein solutions irradiated by helium-neon laser in the presence of hydrogen peroxide was observed by both polarizing microscopy and spectrophotometry. High molecular weight (2.10(6) Da) and heavily glycosylated (about 80%) glycoprotein was isolated from the mucus layer of pig small intestine.

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On the basis of the data obtained during examination of 27 children, the authors present the criteria of the differential diagnosis of hereditary diseases of the neuromuscular diseases and their phenocopies. It has been shown that the myopathic syndrome may develop in perinatal and infectious lesions of the nervous system, dermatomyositis, rickets and bone disease.

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The review analyses the available evidence on the role of acid and alkaline phosphatases, ATPase as well as non-organic phosphate in the processes of precipitation of insoluble calcium salts in tissues. Participation of phospholipids in this process is noted. The identical role of the ensymatic systems in calcification in the processes of bone formation and in pathological foci including tumours is demonstrated.

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