CIC/ATXN1-rearranged tumors in the central nervous system are mainly represented by sarcomas: A comprehensive clinicopathological and epigenetic series.

CIC fusions have been described in two different central nervous system (CNS) tumor entities. On one hand, fusions of CIC or ATXN1 genes belonging to the same complex of transcriptional repressors, were reported in the CIC-rearranged, sarcoma (SARC-CIC). The diagnosis of this tumor type, which was recently added to the World Health Organization (WHO) Classification of CNS tumors, is difficult mainly because the data concerning its histopathology (as compared to its soft tissue counterpart), immunoprofile, and clinical as well as radiological characteristics are scarce in the literature.

Security and reliability of CUSTOMBONE cranioplasties: A prospective multicentric study.

Background: Repairing bone defects generated by craniectomy is a major therapeutic challenge in terms of bone consolidation as well as functional and cognitive recovery. Furthermore, these surgical procedures are often grafted with complications such as infections, breaches, displacements and rejections leading to failure and thus explantation of the prosthesis.

Objective: To evaluate cumulative explantation and infection rates following the implantation of a tailored cranioplasty CUSTOMBONE prosthesis made of porous hydroxyapatite.

Is More Always Better?: Discovering Incentivized mHealth Intervention Engagement Related to Health Behavior Trends.

Behavioral medicine is devoting increasing attention to the topic of participant engagement and its role in effective mobile health (mHealth) behavioral interventions. Several definitions of the term "engagement" have been proposed and discussed, especially in the context of digital health behavioral interventions. We consider that engagement refers to specific interaction and use patterns with the mHealth tools such as smartphone applications for intervention, whereas adherence refers to compliance with the directives of the health intervention, independent of the mHealth tools.

wrapper: Operationalizing engagement strategies in mHealth.

The advancement of digital technologies particularly in the domain of mobile health (mHealth) holds great promise in the promotion of health behavior. However, keeping users engaged remains a central challenge. This paper proposes a novel approach to address this issue by supplementing existing and future mHealth applications with an engagement wrapper - a collection of engagement strategies integrated into a single, coherent model.

Acceptability of smartphone technology to interrupt sedentary time in adults with diabetes.

Breaking up sitting time with light- or moderate-intensity physical activity may help to alleviate some negative health effects of sedentary behavior, but few studies have examined ways to effectively intervene. This feasibility study examined the acceptability of a new technology (NEAT!) developed to interrupt prolonged bouts (≥20 min) of sedentary time among adults with type 2 diabetes. Eight of nine participants completed a 1-month intervention and agreed that NEAT! made them more conscious of sitting time.

Intradural extramedullary spinal metastases of non-neurogenic origin: a distinct clinical entity or a subtype of leptomeningeal metastasis? A case-control study.

Background: Leptomeningeal metastases from carcinoma are still poorly understood.

Objective: To better define the management of unique intradural extramedullary spinal metastases (IESM) from solid cancers of non-neurogenic origin, in particular regarding leptomeningeal metastasis (LM).

Methods: We conducted a retrospective, multicenter, case-control study including 11 patients with IESM matched with 11 patients with LM.

[Peculiarities of professional burnout of anaesthetists-experts in resuscitation in various age periods].

The article is devoted to consideration of the problem of professional burnout with anaesthetists-experts in resuscitation in various age periods that is very actual in modern medicine. It is shown that peculiarity of the doctors' activity provokes formation of professional burnout in them. Psycho-emotional tension born by the sense of responsibility before the patients determines formation of responsible attitude of the doctors towards therapy, but it also has negative consequences in concern with disorder of homeostatic balance and unreasonable energetic expenditure.

[Psycho-physiological peculiarities of stomatologists aged 50-65 with essential hypertension].

The article presents the results of studying of psycho-physiological peculiarities in stomatologists in the age before 65, that is actual in modern medicine. Certain specificity of psycho-physiological indices in stomatologists with essential hypertension is shown. The proposition is justified that alexithimia and susceptibility to illnesses of psychosomatic origin (particularly, essential hypertension) in stomatologists are essentially influenced by withdrawal, absence of inclination to partnership, cooperation, compromise at solution of problems and in conflict situations, and irresponsible attitude to other people, reduced empathy and sympathy to other people.

[Intermittent prolonged fever triggered by efforts].

Introduction: Fever of unknown origin is a common reason for care in internal medicine. The wide variety of possible etiologies makes it difficult to standardize the diagnostic work-up that has to be primarily guided by the interview and physical examination.

Case Report: We report a case of prolonged fever having as main characteristics to be intermittent and triggered by efforts.

[Inhibition of lipase activity by low-molecular-weight chitosan].

Inhibition of enzymatic activity of lipase (EC 3.1.1.

[Structural and energy changes in water and its biological activity].

The authors consider the structural and energy changes occurring in water during its treatment using physical methods and the impact of these conditions on metabolic processes. Emphasis is laid on the necessity of putting the integral indices, considering the magnitude of changes in the structural and energetic conditions of water and its biological activity, into practice.

[Inhibitors of ribonucleases].

RNases are the most important enzymes of cellular metabolism. They influence gene expression, cell growth and differentiation, participate in cell protection against pathogens and induction of apoptosis. Since intracellular RNases exist mainly in complexes with their inhibitors, the latter are also involved in all above-mentioned processes.

[Mathematical modeling of laser-induced selective destruction of labyrinthine vestibular receptors].

Basing on mathematical modeling, we tried to investigate in humans the ability of laser energy to suppress the function of the ampullar receptors of the semicircular canels and otolith receptors; to elicit mechanism of action of laser energy on labyrinthine receptors. Modeling has shown that in 1 mm thickness of the canal wall laser impact raises temperature of the liquid to 120 degrees C. Temperature higher than 100 degrees C stands in it up to 120 ms.

[Cerebral cavernomas, epilepsy and seizures. Natural history and therapeutic strategy].

Purpose: To review, from a retrospective series of 48 patients presenting with seizures associated with one or more supratentorial cavernoma(s), the natural history of the seizures and outcome according to medical and surgical treatment.

Methods: Patients were divided into two groups: group A included patients presenting with a single seizure or rare seizures (n=21), and group B patients having intractable epilepsy (n=27). All received antiepileptic drugs and 35 were operated on (12 in the group A and 23 in the group B).

[Modern evaluation of the accuracy of determination of the acid-forming function of the stomach by the method of intragastric pH-metry].

Described are the results of research of how the standard location (antral region-stomach body-cardium) of the comparison electrode in the 3-electrode probe affects the clinical evaluation of the acid-forming function of the stomach (AFC) in patients with gastric and duodenal ulcer. It was found that a sufficient accuracy (+/-0.2) in measurements of basal pH of the stomach body and, consequently, in clinical evaluation of AFC for the main standard locations is ensured by pH-probes with the chlorosilver skin comparison electrode.

[Cerebral cavernomas followed by epileptic seizures: clinical picture, diagnosis, and treatment].

The clinical features of epilepsy associated with cerebral cavernomas and the results of different types of its surgical treatment: cavernonectomy, extended cavernomectomy, and epileptic focus resection were analyzed. The clinical, radiological, and electrophysiological data were studied in 48 patients with epileptic seizures associated with cerebral cavernomas who had been admitted to the Unit of Neurosurgery, Saint Anna Hospital (Paris, France) in 1982-2001. According to the severity of epileptic manifestations, the patients were divided into 2 groups: 1) 21 patients with single and rare seizures and 2) 27 patients with drug-resistant epilepsy.

[Accuracy of acidity changes in the gastrointestinal tract as determined by pH-tubes with the internal and external comparison electrodes].

It was for the first time that the presence of diffusive potentials on the borders between segments of the gastrointestinal tract (GIT) with differing compositions and pH values were detected in the practice of pH-metry. The diffusive potentials were found to be a cause for a considerably worsening accuracy of pH measurements by the second measuring electrode of the two-electrode pH-tube with the internal comparison electrode. On the contrary, when pH-tube with the external cutaneous comparison electrode is in use, the measuring accuracy does not deteriorate virtually for all electrodes in the latter case.

[New medical pH probes for the examination of the gastrointestinal system].

The paper deals with pH-probes with mercurius chloride versus silver chloride electrodes for intragastric pH-metry. Present-day oral, transnasal, and endoscopic pH-probes with reusable epicutaneous silver chloride electrode have been designed and introduced into medical practice.

[Changes in clinical-instrumental parameters in patients with mitral stenosis after balloon catheterization valvuloplasty of the mitral valve].

The results of mitral valvuloplasty using a balloon catheter were presented for 104 patients with mitral stenosis. Instrumental measurements and clinical symptoms were evaluated before the operation, 6 and 12 months after it (62 and 42 patients, respectively). The balloon dilatation has increased mitral orifice from 120.

[The use of an automated teaching system in a therapy department].

At the division of general therapy N 1 of the Kirov Military Medical Academy a version of automated training system was elaborated for the IBM AT/386 users of MS DOS operational system. The knowledge text control was carried out during the lessons at the display classroom equipped with Wyse-85 terminals ("Wyse Technology Company"), DEC VT 220 regimen, and connected up to PC IBM AT/386 which works in multiterminal function. Application of text control has shown that the volume of knowledge had increased up to 82-90%, but it was right only for the groups where the methodics of classes with application of the results of text controls was strictly adhered.

[Monocyte functional activity and nonspecific antiviral cellular resistance in adaptation to the conditions of eastern Siberia].

Monocyte functional activity and antiviral cellular resistance were studied in the newcomers to the Baikal region from the European Russia. A total of 105 patients with acute respiratory diseases and 30 normal subjects were examined. 46 healthy residents of St.

[Therapeutic effect of intravascular phosphobion during transesophageal electric cardiostimulation in patients with ischemic heart disease].

The authors propose a new method of treating coronary patients with angina pectoris of effort and at rest. It involves combination of transesophageal pacing with simultaneous intravenous administration of phosphobion. The treatment given to 10 coronary patients produced positive antiischemic and hemodynamic effect against its absence in control subjects treated conventionally with ATP.