Publications by authors named "Iain Parry Hargreaves"
Efficacy and Safety of Coenzyme Q10 Supplementation in Neonates, Infants and Children: An Overview.
Antioxidants (Basel)
April 2024
Article Synopsis
- This article is the first to review the effectiveness and safety of coenzyme Q10 (CoQ10) supplementation specifically in younger populations, including neonates, infants, and children.
- It focuses on cases where CoQ10 supplementation is used due to various medical disorders rather than for healthy individuals, as there is no established need for it in otherwise healthy younger subjects.
- The review covers a range of clinical conditions, such as CoQ10 deficiency, muscular dystrophy, migraines, and other specific health issues in children.
Article Synopsis
- Post-viral fatigue syndrome (PVFS) involves various complex disorders characterized by severe fatigue, muscle and joint pain, cognitive issues, poor sleep quality, autonomic dysfunction, and neuropsychiatric symptoms, including ME/CFS and long COVID.
- There are currently no established clinical guidelines or FDA-approved treatments for PVFS, leading to a pressing need for new therapeutic approaches.
- Recent research highlights the potential role of mitochondrial dysfunction in PVFS conditions, and this article specifically reviews how coenzyme Q10 supplementation could help alleviate chronic fatigue and pain symptoms in these disorders.
Article Synopsis
- Mitochondrial dysfunction and oxidative stress may contribute to various endocrine disorders, highlighting the potential benefits of coenzyme Q10 (CoQ10) due to its protective roles in mitochondria and as an antioxidant.
- The article reviews the impact of CoQ10 deficiency and supplementation specifically in relation to thyroid issues, diabetes, male infertility, and polycystic ovary syndrome.
- Focus areas include conditions like hyperthyroidism and type II diabetes, suggesting CoQ10 could play a significant role in managing these health issues.
Article Synopsis
- * Key questions explored include ways to improve CoQ10's bioavailability, potential intravenous administration, its ability to cross the blood-brain barrier, and how it is transported within cells.
- * The article emphasizes the need for further research to understand why some trials have failed and to identify the best tissues for assessing CoQ10 levels clinically.
Article Synopsis
- - Mitochondrial dysfunction is linked to several neurodegenerative diseases, such as Parkinson's and Alzheimer's, due to its reduced ability to produce ATP, the energy currency of cells.
- - The article discusses how a deficiency in certain nutrients can further impair mitochondrial function, potentially worsening these conditions.
- - It suggests that supplements like CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid may help improve mitochondrial health and aid in treating these neurodegenerative diseases.
We report the cases of two patients who developed worsening behavioural and psychological symptoms of dementia (BPSD), coinciding with starting the factor Xa inhibitor direct oral anticoagulant medications apixaban and rivaroxaban, respectively. Both patients required detaining under the Mental Health Act. Their symptoms improved significantly, within 2 weeks, on switching to alternative anticoagulant therapies and they were both discharged from the acute psychiatric ward.
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