Publications by authors named "Iain Mylchreest"
A 60 microm internal diameter (i.d.) stainless-steel needle was adapted to the orthogonal ESI probe ( microESI) of a commercial ion trap mass spectrometer, and used for capillary liquid chromatography/tandem mass spectrometry (LC/MS/MS) protein identification experiments.
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- Triple quadrupole mass spectrometers are crucial for high-throughput quantitation in pharmaceuticals due to their sensitivity and specificity, especially when operated in multiple reaction monitoring (MRM) mode.
- Recent advancements have improved these instruments to achieve mass resolution of less than 0.1 Dalton, addressing past limitations with interference from matrix components or metabolites.
- The paper highlights the benefits of enhanced resolution, particularly in reducing interference during analyses (like with mometasone and PPG), maintaining sensitivity, and demonstrating stability during extended operation.