Hypotension During Vasopressor Infusion Occurs in Predictable Clusters: A Multicenter Analysis.

Published evidence indicates that mean arterial pressure (MAP) below a goal range (hypotension) is associated with worse outcomes, though MAP management failures are common. We sought to characterize hypotension occurrences in ICUs and consider the implications for MAP management. Retrospective analysis of 3 hospitals' cohorts of adult ICU patients during continuous vasopressor infusion.

Diagnostic suspicion bias and machine learning: Breaking the awareness deadlock for sepsis detection.

Many early warning algorithms are downstream of clinical evaluation and diagnostic testing, which means that they may not be useful when clinicians fail to suspect illness and fail to order appropriate tests. Depending on how such algorithms handle missing data, they could even indicate "low risk" simply because the testing data were never ordered. We considered predictive methodologies to identify sepsis at triage, before diagnostic tests are ordered, in a busy Emergency Department (ED).

End-user evaluation of an interface for clinical decision support using predictive algorithms.

There have been decades of interest in advanced computational algorithms with potential for clinical decision support systems (CDSS), yet these have not been widely implemented in clinical practice. One major barrier to dissemination may be a user-friendly interface that integrates into clinical workflows. Complicated or non-intuitive displays may confuse users and may even increase patient management errors.