[Clinical and morphologic diagnosis of uterine sarcoma].

The results of a clinico-morphological evaluation of the data on 419 patients suffering from uterine sarcoma are presented. It is recommended that dynamic and ultrasonic surveillance of patients with uterine myoma, particularly those in pre- or postmenopause, be carried out for timely detection of leiomyosarcoma. Premorbid pathogenetic status in patients with mixed mesodermal neoplasms and, especially, carcinosarcomas has much in common with the relevant characteristics of hormone dependent adenocarcinoma of the endometrium.

[Therapeutic approach in sarcoma of corpus uteri].

The results of treatment of 419 patients with endometrial sarcoma are presented. Five-year survival was 42.7% and it appeared to depend on histological pattern substantially: leimyosarcoma--49.

[Lymphatic cysts arising after extended surgery for cervical and endometrial tumors].

Retroperitoneal lymphatic cysts account for 10.0-15.0% of complications of extended hysterectomy for tumors of the cervix uteri and endometrium.

[Association of papillomavirus infection and latent hyperprolactinemia in patients with dysplasia and preinvasive cancer of the cervix uteri].

Gynecological screenings carried out in I, 247 females and supplemented by cytological examination of ectoendocervical mucosa smears established significantly higher rates of detection of cytological signs of papillomavirus infection (PVI), regardless of age, in cases of background pathologies of the uterine cervix (10.0%) than in females without detectable pathology of the ectocervix (3.6%).

[The indications for second-look laparotomy in ovarian cancer patients].

Data on 304 patients with ovarian malignancies (mostly epithelial-72.0%) who had undergone second-look surgery were analysed to develop indications and assess the clinical value of the procedure. Second-look operations were performed 10-22 months after primary surgery in the following clinical settings: (1) clinical remission if wash-offs from the Douglas' pouch peritoneum revealed tumor cells or a high blood-CA-125 level was established (8 patients with stage I-II cancer), (2) remission after 6-10 courses of combination chemotherapy (13 patients with stage III-IV tumor), (3) remission following non-radical primary surgery (117 cases), (4) patients with suspected relapse (144), and (5) cases who were not suspicious for relapse but required laparotomy for concomitant surgical pathology such as, for instance, ventral hernia (22).

[Multifactorial analysis of the effect of metabolic and endocrine factors on cellular immunity in patients with cancer of the uterine body].

Multifactorial analysis of effects of metabolic and endocrine determinants of the host and morphology of the tumor on cellular immunity has been undertaken in 29 patients with cancer of the corpus uteri. Several regression models obtained using the Hocking-Leslie method demonstrated significant effects of age, obesity, triglyceride levels, morphologic differentiation of the tumor and magnitude of invasion on various levels of cellular immunity, presenting as an increase in T-helper and decrease in suppressor counts. The multifactorial analysis depicted additive effects of endocrine homeostatic determinants and the tumor on different aspects of cellular immunity in cancer of the corpus uteri.

[Hyperprolactinemia as a marker of the progression of cervical cancer].

Elevated blood prolactin level was identified in 80% of untreated patients with advanced (stage II-IV) cervical cancer whereas it was normal at the earlier (preinvasive) stage. Patients with stage I-A, II tumors revealed either increased or normal blood prolactin level. Patients with advanced cancer who had undergone irradiation and surgery, either alone or in combination, showed hyperprolactinemia as often as 94% of the time.

[Treatment of patients with vulvar cancer].

Data concerning patterns of dissemination and recurrence as well as the end results of treatment of 148 cases of vulvar cancer were used to develop adequate therapeutic options for the disease versus age and extent of tumor. Prophylactic and therapeutic removal of the inguinal and femoral lymph nodes, high radicality of vulvo- and lymphadenectomy, and fast electron irradiation assured a better prognosis.

[The effect of hydroxyprogesterone caproate and its combination with tamoxifen on steroid hormone receptors in the tumor and on the basic parameters of reproductive homeostasis in patients with cancer of the corpus uteri].

Oxyprogesterone capronate (OPC) was administered preoperatively to 46 patients with endometrial tumors and tamoxifen (T) + OPC--to 72 patients. Complex treatment was followed by more pronounced pathomorphosis in tumor. Both schedules inhibited gonadotropin secretion and lowered colpocytoscopic indexes.

[Effect of tamoxifen on the content of cytoplasmic steroid hormone receptors of the tumor in patients with cancer of the corpus uteri].

A direct correlation between steroid hormone receptor level, tumor differentiation and pathogenetic pattern of tumor was established in 49 patients with endometrial carcinoma. Dynamics of tamoxifen-induced changes in progesterone receptor level proved an important criterion of hormone dependence of endometrial tumor.

[Treatment of patients with sarcoma of the uterus].

The choice of treatment for uterine sarcoma should be determined by histological pattern and stage of tumor as well as by the patient's general condition. Operation should be withheld unless it is life-saving. The extent of surgery should vary from extirpation of the uterus with the appendages (leiomyosarcoma) to extended extirpation with pelvic lymphadenectomy for mixed mesodermal tumor, carcinosarcoma and endometrial stromal sarcoma.

[Effect of progestin therapy on the level of cytoplasmic receptors in patients with cancer of the corpus uteri].

Correlations were identified between tumor morphobiochemical characteristics and basic parameters of reproductive homeostasis in 256 cases of endometrial carcinoma. A correlation was established between the levels of cytoplasmic receptors to estradiol (ER) and progesterone (PR), on the one hand, and morphological differentiation and spontaneous secretion in tumor tissue, on the other. A direct correlation was found between ER and metastatic spread to regional lymph nodes, and no correlation--between ER and PR and major parameters of reproductive homeostasis.

[Individualization of the indications for the postoperative tele-irradiation of patients with I-stage endometrial cancer].

Regression nonparametric model after Cox was used to assess the role of postoperative irradiation in combined and complex treatment for endometrial carcinoma. Radiotherapy was found to produce no significant impact on patients survival. The results of surgical, combined and complex treatment of 465 patients with stage-I endometrial carcinoma were compared.

[Factors influencing the prognosis of radiation therapy of patients with uterine cancer].

The results of radiation treatment of 390 cases of cancer of the corpus uteri were analysed. Five-year survival rate for the whole group was 62.1%.

[Effect of adjuvant hormonotherapy on the results of the radiation treatment of patients with cancer of the corpus uteri].

The paper discusses the results of treatment of endometrial cancer patients with high energy radiation (76 cases). Three-year survival rate was 78.3%.

[Experience with clinical use of human leukocyte interferon in cancer of the cervix uteri].

Interferon was injected intracervically as the first stage of combination treatment in 110 cases of histologically-verified Ca in situ and invasive cervical carcinoma. Colpomicroscopic, cytologic and histologic examination was carried before and after treatment. Posttreatment histologic examination failed to detect any tumor cells in 31 patients (28.

[Nonspecific gamma-esterase in the tissues in endometrial cancer].

Malignization of endometrium is accompanied by an increase in the production of nonspecific tissue gamma-esterase (NTE). NTE content in uterine tissues and mucus of patients with cancer of endometrium correlates with a degree of differentiation, spreading and depth of tumour cell invasion into the myometrium. The synthesis of NTE occurs in epithelial cells of the endometrium glands which secrete it into the uterus cavity.

[Malignant tumors of the genitalia in girls].

A review of the literature and analysis of 40 cases of genital malignancies girls are presented. 31 patients had ovarian tumor, 2--cervical, 4--vaginal and 3--tumor of the vulva. Most embryonal rhabdomyosarcoma of the vagina or the vulva occurred in patients under 4 whereas ovarian neoplasms (mostly germ and sex cord tumors) were observed at prepubertal and pubertal age.