[Radiation modulating properties of derivates of 1,4-dihydropyridine and 1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8 dione].

First attempt to analyse radiation modifying action of 52 compounds--derivatives of 1,4-dihydropyridine is presented. Many of these compounds have electrodonating and antioxidative activities. Local radioprotective effects of the substances has been studied using experimental model with partial beta- and X-rays exposure of sole skin in rats to doses of 40 and 30 Gy.

[Clastogenicity of ethyl methanesulfonate and dimethyl terephthalate in the micronucleus test and ways for its modification].

In the mouse transplacental test, EMS induced micronuclei and disturbed haemopoiesis in female bone marrow and foetal liver. Dimethyl terephthalate at the tested dose was ineffective in pregnant females increasing however the level of these events in foetuses. Hence, both the alkylating agent and the phthalate derivative penetrate placenta and are dangerous for embryos.

[1,4-dihydroisonicotinic acid (1,4-DHINA) derivatives, inhibitors of chemical mutagenesis].

The paper summarizes the results of studies into the modifying effect of some 1,4-dihydroisonicotinic acid (1,4-DHINA) derivatives during chemical mutagenesis in eukaryotic organisms. The compounds under study are effective in reducing the incidence of point and chromosomal mutations induced by ethylmethane sulfonate (EMS) in Drosophila sex cells, displaying the specificity of the influence depending on some factors. The effects of these antimutagens on the formation and repair of chromosomal breaks were studied during mutagenized sperm storage in Drosophila female receptacula semenis.

[Effects of cerebrocrast on local cerebral circulation and EEG in cats with cerebral hemorrhage].

In experiments on awake cats before and after intracerebral hemorrhage influence of cerebrocrast and nimodipine intravenous infusion (1 microgram/kg-1/min-1 during 60 min) on cerebral blood flow (CBF) in the cortex, thalamus and reticular formation and power of (alpha + beta)-, theta-, and delta-waves was investigated. During cerebrocrast infusion increasing CBF and improving bioelectrical activity were demonstrated.