[Model of ion diffusion in synaptic cleft based on stochastical integration of langevin equation at dielectric friction approximation].

Changes in the state of the central nervous system, leading to the development of pathological processes, are directly associated with a state of neurons, particularly with their conductivity in synaptic cleft region. The synaptic flexibility plays a key role in environmental adaptation, which manifests in dynamic changes of synaptic properties. However more attention was paid rather to their functional, than physical-chemical properties.

[Computer modeling of spatial-time distribution of metabolite concentrations in phantoms of biological objects by example of rat brain pial].

A method for quantitative assessment of the metabolite concentrations in digital phantoms of the biological objects has been proposed. The objects under consideration are expected to have a complex geometry of diffusive sources. We present an algorithm for calculation of non-steady state gradients of the diffusing compounds under their constant border concentration.

[Anticonvulsants as bioantioxidants under stress conditions].

The action of heterocyclic amides series (ethosuximide, phenytoin, primidone) on lipid peroxidation and membrane bound monoamine oxidases A and B under stress condition has been studied. The intraperitoneal injection of the drugs resulted in enhancement of SOD, decrease of brain malondialdehyde content and mitochondrial activity of monoamine oxidases A and B.

[Application of Brownian dynamics to the description of transmembrane ion flow as exemplified by the chloride channel of glycine receptor].

Using the Brownian dynamics of the movement of hydrated ion in a viscous water solution, a mathematical model has been built, which describes the transport of charged particles through a single protein pore in a lipid membrane. The dependences of transmembrane ion currents on ion concentrations in solution have been obtained. It was shown that, if the geometry of a membrane pore is identical to that of the inner part of the glycine receptor channel and there is no ion selectivity, then the values of both chloride and sodium currents are not greater than 0.

[Oxidative stress and oxygen status in ischemic stroke].

A dynamic assessment of oxygen status of the arterial blood, activity of antioxidant system enzymes (AOS), succinatedehydrogenase (SDG), mitochondrial alpha-glycero-phosphate-dehydrogenase (alpha-GPDH) and alkaline phosphatase (AP) as well as concentrations of reduced glutathione (GSH) and secondary products of lipid peroxidation reacting with thiobarbituric acid (PLPRTA) has been carried out in patients at the acute stage of ischemic stroke of hemispheric location. Relative hyperoxia as a result of the hyperventilation syndrome was mostly pronounced on day 1 and 3. At the same time, a reduced activity of AOS system and an increase of PLPRTA concentration have been observed from the 1st day after stroke.

[A mathematical model of conformational changes in membrane protein part of F0F1-ATP synthase].

The transformation of the electrochemical membrane proton gradient into the energy of chemical bond in adenosinetriphosphate is one of the most important biological processes occurring in the living cell. The main enzyme that directly catalyzes the synthesis of ATP from ADP and Pi in aerobic conditions is F0F1-ATP synthase. In the present study, conformational changes in membrane protein part of ATP synthase during its catalytic cycle were described in terms of dynamic equations of solid state rotation.

[Mathematical modeling of non-stationary spatial gradients of nitric oxide in the muscle wall of blood vessels].

A mathematical description of the diffusion of low-mass uncharged molecules in homogenous biological medium was considered. The distribution of nitric oxide in vascular smooth muscles was taken as an example. The model makes it possible to describe the spatial-temporal gradient of NO near the surface of endothelium in terms of one-dimensional diffusion.

[Control of the rate of the glucokinase reaction by its elementary stages].

Limitation of an enzymatic reaction by its elemental steps is characterized by so-called control coefficients for (quasi)stationary reaction rate. Established paradigm of "limiting step" cannot describe the control of glucokinase reaction. Flux control is distributed between several elemental steps (ATP binding, ADP release, etc.

[The use of glutathione as a protector agent in hypoxic exposure].

The antihypoxic effect of glutathione was studied in a pressure chamber of acute hypoxic hypoxia and in the perfused heart of non-inbred rats. The body's natural metabolite glutathione was found to show the properties of an active antihypoxant, a protector of energy action. The mechanism of this action of glutathione may be associated with decreased hyper-recovery of the mitochondrial respiratory chain and with its restored capacity to synthesize ATP at the first point of oxidative phosphorylation.