[The use of ketamine in an experimental model of generalized cerebral ischemia].

Thus far, a sufficiently effective cerebroprotective substances has not been discovered. Glutamate overproduction plays a key role in ischemic brain lesion. Ketamine is assigned to the group of commonly used clinical anesthetics, being also familiar as NMDA antagonist.

[Glutamate antagonists--a new stage in the development of cerebral protection?].

This is a survey of 35 papers, published in medical journals worldwide over the past 5 years, in an attempt to disclose the current level of understanding the fine biochemical mechanism underlying neuronal lesions, as well as to outline the possible trends of cerebroprotective therapy evolution, as put forward by the authors of the cited works. A number of researches demonstrate the role of glutamate and other excitatory amino acids in neuronal lesions' development during hypoxia, hypoglycemia, cranio-cerebral trauma and the like. It is logical to presume that the antagonists of glutamate receptors and their relationship to ionic canals may be considered as having an essential bearing on the build-up of a complex cerebroprotective strategy, corroborated in turn by a number of studies on cell cultures in vitro, and in numerous animal models as well.

[A case of an impossible cannulation of the v. jugularis and v. subclavia in a female patient with longstanding myasthenia gravis and immunosuppressive therapy].

The report deals with a female patient presenting myasthenia gravis of 8-year duration, maintained on continuous APV, repeatedly cannulated central veins, and immunosuppressive therapy with corticosteroids--Imuran and Sandimmun. Repeated CT examination of the mediastinum fails to detect any process. The consecutive scanning is necessitated because of the impossibility to cannulate v.