[Comparative efficacy of various thrombolytic agents in treatment of pulmonary embolism].

The authors carried out a retrospective analysis of clinical efficacy of streptokinase and alteplase (actilyse®) in patients presenting with high- and intermediate-to-high risk pulmonary artery thromboembolism (PATE) who were discharged from hospital after appropriate treatment performed. Of the total number of the treated patients, we formed 2 groups comprising 20 patients each, receiving alteplase (group 1) and streptokinase (group 2). The patients were comparable by the main clinical characteristics, predisposing factors, severity of pulmonary artery thromboembolism (PATE) and duration of treatment.

[Temporary tamponing of the canal while removing the great saphenous vein in elderly patients].

The purpose of the study was to optimize the technique of removing the trunk of the great saphenous vein (GSV) in patients over 60 years. The study included a total of eighty-five patients aged over 60 years and presenting with primary varicose veins of the lower limbs and undergoing operations performed on the superficial venous system, including all stages of classical phlebectomy - crossectomy, stripping of the GSV, removal of tributaries and ligation of incompetent perforant veins. The patients were divided into two groups: the Study Group (n=44) patients endured removal of the GSV with the use of the technique of temporal tamponing of the canal, while in Group Two patients, composing a comparison group (n=41), the GSV was removed without the use of a tampon.

[Use of a thrombin inhibitor for treatment of deep vein thrombosis and pulmonary thromboembolism in patients with thrombophilia].

Presented herein are the results of oral administration of dabigatran etexilate for treatment and secondary prevention of lower-limb deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE) in patients with established thrombophilia, studying its efficacy and safety in prolonged administration during a year as compared with warfarin. The study group included a total of fifty-seven 18-to-79-year-old patients (33 men and 24 women) with DVT and PTE, taking dabigatran etexilate. The comparison group was composed of a total of 126 patients (65 men and 61 women) with DVT and PTE, taking warfarin.

[Seasonal cyclicity of acute arterial ischaemia and acute ascending varicothrombophlebitis].

The authors studied the seasonal cyclicity of the thrombotic and embolic process in the veins of the upper and lower extremities, as well as acute ascending varicothrombophlebitis in the great and small saphenous veins over eleven years. The study included a total of 1,513 patients. Of these, 593 (39.

[Clinical features of systemic scleroderma with lesions in respiratory organs].

This retrospective study included 64 patients divided into 2 groups. Group 1 was comprised of 34 patients with systemic scleroderma and signs of interstitial lung lesions (X-ray diagnostics), the control group included 30 patients with scleroderma alone. They were examined by general clinical, biochemical and immunological methods, ECG, Echo-CG, capillaroscopy, standard chest X-ray, spirometry, ultrasound studies of internal organs, oesophageal, gastric and duodenal endoscopy.

[Peculiarities of thrombin generation and prognosis of unfavourable outcome in patients with severe pneumonia and pneumogenic sepsis].

The study of thrombin production included 68 patients with severe pneumonia (SP) undergoing monitoring plasma thrombin potential in the thrombin generation test. Thrombin production was found to decrease in the patients who died compared with those alive on days 3-5 and 7-10 after onset of the disease. Endogenous thrombin potential decreased progressively during the first 7-10 days among the patients with the fatal outcome of SP.

[New approaches to primary differentiation of dyspnea in patients with pulmonary and cardiac pathology].

This study was aimed at searching new instruments for primary differentiation of dyspnea associated with lung or heart pathology. The study consisted of 3 stages and included analysis of "glossary dyspnea" of 482 patients aged 18-90yr. Stages i and II involved 359 patients with the known diagnosis: chronic obstructive pulmonary disease (COPD) (n=114, 31.

[Comparative evaluation of the health status of descendants of people residing in environmentally unfriendly regions by means of mathematical modeling].

The aim of the study was to evaluate reproductive health of descendants of people who experienced effects of adverse environmental factors, such as radiation and chemical contamination (the descendants themselves were unaffected by these factors). Reproductive health of women was assessed by mathematical modeling. Factors of greatest importance for the health status of the descendants were distinguished among the 76 ones studied.

Clinical variants of severe pneumonia.

Pneumonia is a most common human disease and a leading cause of death from infectious pathology. The mortality rate amounts to 5.20% despite the improvement of the existing methods of treatment.

[Treatment of the acute lung abscess without sequestration].

The study aimed to assess the efficacy of the adopted principles of the treatment of lung abscess without sequestration on the example of 2397 patients. Treatment led to the complete recovery in 1731 (72,2%) patients. The 614 (25,6%) patients showed the chronization of the process and 52 (2,2%) died.

[Obstructive sleep apnea syndrome in patients with chronic obstructive pulmonary disorder].

Sleep obstructive apnea syndrome (SOAS) is a life-threatening respiratory disorder. Its combination with COPD further deteriorates respiratory distress and accelerates the development of pulmonary hypertension (crossover syndrome). Systemic inflammation with concomitant oxidative stress in patients with SOAS and COPD suggests their influence on the development of circulatory disorders.

[The investigation of prevalence of genital inflammation in women of second generation of descendants whose ancestors were in the area of radiation exposure].

There are the results of a comprehensive clinical examination of 112 women of childbearing age who are second generation descendants of those who were in the area of radiation exposure over 25 ED cSv. Incidence and factors leading to chronic inflammation of pelvic organs were studied. Immune status was evaluated by studying of subpopulation of immune cells in peripheral blood and levels of basic inflammatory cytokines.

[Computed tomographic findings in patients with chronic pulmonary obstruction and diabetes mellitus].

The study included 40 patients aged 33-71 years with chronic pulmonary obstruction (CPO) and diabetes mellitus (DM). They were examined by multilayer CT with detailed analysis of parenchymal tissues. The main microvascular changes in lung parenchyma included dilation, focal opacity (2-5 mm), and beaded vessels.

[The specific features of respiratory support in patients with obstructive sleep apnoea syndrome concurrent with chronic obstructive pulmonary disease (crossing-syndrome)].

Aim: To determine the specific features of respiratory support in patients with obstructive sleep apnoea syndrome (OSAS) concurrent with chronic obstructive pulmonary disease (COPD).

Subjects And Methods: Thirty-six patients with OSAS concurrent with COPD were examined. External respiration function, apnoea/hypopnoea index, and arterial gas composition were determined in all the patients.

[Digestive system pathology in patients with chronic obstructive pulmonary disease concurrent with coronary heart disease].

Aim: to study clinical and functional impairments in the digestive system in patients with chronic obstructive pulmonary disease (COPD), including that in the presence of coronary heart disease (CHD).

Subjects And Methods: Clinical and functional impairments were analyzed in 1104 patients. Of them, 402 patients had COPD (Group 1); 459 had COPD concurrent with angina on exertion (Group 2); 243 had CHD (Group 3).

[Peculiarities of the treatment of obstructive pulmonary disease in patients with combined pathology].

Effects of combined drug therapy were evaluated in 97 patients during a year Group 1 comprised 32 patients with chronic obstructive pulmonary disease (COPD), group 2 (n = 34) included patients with COPD and angina of effort, group 3 (n = 31) patients with CHD. Broncholytic therapy was prescribed in compliance with GOLD (2006) recommendations. Patients in groups 2 and 3 continued to receive antianginal therapy started before the onset of the study.

[The possibility of clinical diagnosis of non-massive pulmonary thromboembolism under conditions of limited availability of instrumental diagnostic tools].

The study included 105 patients with local segmental microcirculatory disturbances in the lungs and X-ray detectable pathologic changes of different localization or without them. The control group comprised 71 patients in whom perfusion scintiography revealed normal pulmonary circulation. Data on the patients' history, clinical and physical characteristics, results of laboratory analysis, functional-diagnostic, ultrasound and X-ray studies are presented.

[Urogenital pathology in patients with chronic obstructive lung disease and ischemic heart disease].

The objective of this study was to elucidate the incidence and clinical features of renal dysfunction and urogenital system disorders in 956 patients with chronic obstructive lung disease (COLD) and/or coronary heart disease (CHD). COLD was diagnosed in 346 patients (group 1), COLD and CHD in 402 (group 2), CHD in 211 (group 3). The methods included X-ray studies (survey and excretory urography), functional diagnostics (ECG, Doppler cardiography, assessment of external respiration, abdominal, renal, and bladder ultrasound, measurements of residual urine, transrectal and transabdominal examination of prostate).

[Heart rhythm disturbances in patients with chronic obstructive pulmonary disease in aggregate with coronary heart disease].

The purpose of the research was to study kinds, frequencies and features of heart rhythm disturbances (HRD) in patients with chronic obstructive pulmonary disease (COPD) subject to degree of severity, including presence of coronary heart disease (CHD). 1189 of patients with registered HRD were examined. 315 of them had COPD (group 1), 531--combination of COPD and CHD (group 2), 343 were CHD patients (group 3).

[Local permanent intraarterial antimicrobic therapy in postoperative period at the patients with cholangitis].

Method of local permanent intraarterial antimicrobic therapy was used in postoperative period at the patients with acute cholangitis. The method includes transfemoral catheterization of hepatic artery and permanent infusion of ceftriabol (2.0 ml per day) and metronidazol (1.

[Remote results of ultrasonic endarterectomy].

The authors carried out a comparative retrospective study of the efficacy of ultrasonic endarterectomy used for the restoration of the blood flow in patients diagnosed with atherosclerotic lesions of the femoral artery. The long-term outcomes of the operation (with the duration of the follow-up period amounting to 16 years) were analysed in a total of 535 patients. Based on the variety of different types of the operations performed, the patients were subdivided into three groups: Group I consisted of 208 subjects having undergone ultrasound-mediated endarterectomy, Group II comprised 244 patients having endured femoropopliteal bypass grafting with the reversed autovein above the knee joint; and Group III was composed of 83 patients following mechanical endarterectomy.

[Arterial hypertension in patients with chronic obstructive pulmonary disease in combination with coronary artery disease].

Aim: To study clinicofunctional features of arterial hypertension (AH) in patients with chronic obstructive pulmonary disease (COPD) including COPD patients with coronary artery disease (CAD); 24-h profile of blood pressure (BP) and changes in intracardiac hemodynamics; to compare the disturbances detected.

Material And Methods: 1256 patients were divided into 3 groups, 395 AH patients with COPD entered group 1; 509 AH patients with COPD and CAD, angina of effort--group 2, 352 AH patients with CAD--group 3.

Results: Most patients with comorbid diseases have 24-h BP profile of non dipper and night picker types in the presence of high heart rate explained by COPD effect on AH course.

[Means of improvement of surgical treatment for oropharyngeal planocellular carcinoma].

A new technique of intraoperative bolus-assisted administration of chemical drugs for oropharyngeal carcinoma has been developed. In tongue tumor, the lingual artery was ligated at the site of origin from the external carotid artery and catheter was installed after venous flow was blocked. Bolus was used to administer 5-fluorouracyl intraoperatively before and after removal of primary tumor.

[Surgical method in treatment of squamous cell carcinoma of the mouth cavity and oral part of the pharynx].

Surgical method of treatment was used in 194 patients with tumors of the mouth cavity and oral part of the pharynx. Combined treatment (radiation therapy and operation in various combinations) was used in 110 of these patients and in 84 patients the treatment was complex (polychemotherapy + operation + postoperative course of radiation therapy). Comparative characterization of operations fulfilled on the initial focus has shown that the number of function-saving operations in the group of patients treated by complex methods was 86.