[Ceramides and gangliosides in benign and malignant human ovarian tumors].

Composition and content of ceramides and gangliosides from different kinds of human ovary benign and malignant epithelial tumours were studied. The ceramide content was shown to decrease significantly in the tumours, especially in malignant tumours, in comparison with the normal ovary tissue. In the tumour ceramides a sphingosine base composition changes: sphinganine was found along with sphingenine, which is characteristic for normal ceramides.

[Human ovarian ceramides and gangliosides in aging].

The age dependence of the ceramide and ganglioside content in human ovaries has been studied. It has been found that the ganglioside content does not change upon ageing, while the ceramide content alters with age, showing initial increase around the age of 45-47 years but then drops drastically. The composition of gangliosides undergoes drastic changes in the course of time, GM3 and GD3 being the major gangliosides in human ovaries.

[Amides of ganglioside GD3].

Analysis of natural ganglioside lactones usually employs NH3 treatment. In the present paper it has been shown that the GD3 dilactone forms with ammonia three rather than one GD3 amides--a GD3 diamide and two GD3 monoamides. The structure of these amides is discussed.

[Comparative study of lymph node gangliosides and blood serum of normal and T-lymphotrophic baboons].

The gangliosides from the lymph nodes and blood sera of normal and T-lymphomic baboons were studied. In lymph nodes the major gangliosides were identified as GM3 and GD3, those in blood sera--as GM3, GM1 and GD3. Gangliosides GM3 and GD3 contained N-acetyl as well as N-glycoloyl neuraminic acids.