[Progressive multifocal leukoencephalopathy in HIV-positive individuals].

The article discusses the historical aspect and modern ideas about the etiology and pathogenesis of progressive multifocal leukoencephalopathy in patients with HIV infection. An analysis and synthesis of literature data on the clinical presentation of this pathology was carried out. The possibilities and limitations of laboratory and instrumental diagnostic methods, including neuroimaging methods, are discussed in detail.

Comparison of Steroidogenic and Ovulation-Inducing Effects of Orthosteric and Allosteric Agonists of Luteinizing Hormone/Chorionic Gonadotropin Receptor in Immature Female Rats.

Gonadotropins, including human chorionic gonadotropin (hCG), are used to induce ovulation, but they have a number of side effects, including ovarian hyperstimulation syndrome (OHSS). A possible alternative is allosteric luteinizing hormone (LH)/hCG receptor agonists, including the compound TP4/2 we developed, which remains active when administered orally. The aim was to study the effectiveness of TP4/2 (orally, 40 mg/kg) as an ovulation inducer in FSH-stimulated immature female rats, compared with hCG (s.

Stimulation of Ovulation in Immature Female Rats Using Orthosteric and Allosteric Luteinizing Hormone Receptor Agonists.

Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) are widely used for the treatment of reproductive disorders and for controlled ovulation induction, but their use is limited by side effects. Allosteric agonists of the LH/hCG receptor, including thieno[2,3-d]thienopyrimidine TP03 developed by us, can become an alternative. TP03 (50 mg/rat, i.

[The structure of stroke and the effect of somatic and addiction diseases on its appearance and course in patients with HIV infection].

Objective: To study the contribution of somatic and addiction diseases to the formation and course of acute cerebrovascular accidents in people with HIV infection.

Material And Methods: The study included 123 patients with HIV infection, aged 27 to 86 years, who were treated in the primary vascular departments of hospitals in the Tyumen region in the period from 2013 to 2019. The patients were divided into two groups corresponding to the typology of stroke.

[Experience in the management of patients with genetic epilepsies and epileptic encephalopathies in the outpatient practice].

Objective: To describe the spectrum of being detected gene mutations in patients with epilepsy in clinical practice of neurologists specializing in epilepsy with an analysis of diagnosed epileptic syndromes, the characteristics of seizures, the timing of a genetic diagnosis, options and treatment effectiveness.

Patients And Methods: The study included 100 patients (40 boys, 60 girls) with epilepsy and/or epileptic encephalopathy and a gene mutation identified. The average age was 6.

[Secondary spondylogenic epidural abscess].

The article presents the results of a retrospective analysis of 200 patients with hematogenous osteomyelitis of the spine who were treated in the Tyumen Regional Clinical Hospital #2. Neurological disorders were present in 37 patients (group I); 163 patients (group II) had no neurological disorders; according to CT and MRI, secondary spondylogenic epidural abscess was diagnosed in 24 patients. At admission, the severity of neurological deficit assessed using the Frankel scale was as follows: Grade A - 6 cases, Grade B - 7 cases, Grade C - 17 cases, Grade D - 5 cases, and Grade E - 2 cases (epidural abscess without neurological deficit).

[Modern problems of stroke at different hospitalization stages based on the data of the Regional Vascular Center of Tyumen].

Aim: To analyze clinical and organizational aspects of stroke patients care and factors affecting the outcomes of the disease at the prehospital and inpatient stages.

Material And Methods: The medical documentation of patients with acute vascular lesions of the brain who were admitted and were subsequently treated at the Regional Vascular Center in Tyumen in 2016-2018 was studied retrospectively. At the first stage, factors affecting the delay in admission of patients (n=173) to the hospital were identified.

[Intrathecal administration of drugs].

The article summarizes the introduction of drugs into the cerebrospinal fluid. Indications and contraindications for the administration of pharmaceuticals in the cerebrospinal fluid spaces are presented. Main groups of pharmacological agents used for endolumbar introduction and conditions under which they are used, as well as advantages and disadvantages of this treatment are considered.

[Meteorological risk factors of stroke].

Based on correlation analysis of stroke, recorded in Khanty-Mansiysk during 5 years, and standard meteorological factors, we found the significant relationship between the frequency of stroke and daily temperature amplitude. The positive correlation between the frequency of stroke and between-day changes in air temperature in the combination with changes in atmospheric pressure during 3 h was identified. A maximal number of strokes was recorded in December, April, May and July and a minimal number was in January, June, August and September.

[Clinical and epidemiological characteristics of stroke in the Khanty-Mansi autonomous region].

A study of registry data revealed that morbidity, mortality, early lethality and frequency of secondary cases of stroke were significantly lower compared to those in the Russian Federation that could be explained by the younger mean age of the population in the Khanty-Mansi autonomous okrug (KMAO). Annual frequency of new cases of stroke among men was higher than among women though the prevalence of risk factors was lower in men. The levels of morbidity in men and women differed significantly than in the country as a whole.

[Prevalence and risk factor structure of cerebral stroke in people of the Khanty-Mansi autonomous okrug].

Based on the data of cerebral stroke register carried out in the Khanty-Mansi autonomous okrug in 2004-2007, the information on the prevalence of main risk factors has been obtained. Arterial hypertension is the most significant risk factor for all forms of acute cerebral blood flow disturbance. Comparison of prevalence of main risk factors of stroke in residents of this region and people of other regions of the Russian Federation has revealed significant differences for all factors, with the exception of alcohol abuse.

[Disturbances of blood lipid content after acute disorders of brain blood flow].

The parameters of blood lipid spectrum have been analyzed in 421 patients who survived cerebral stroke and transitory ischemic attacks in 2004-2008. The study included people of Khanty-Mansiysk and Khanty-Mansi autonomous okrug and watchmen. The statistical analysis did not reveal differences between mean concentrations of total cholesterol, high and low density lipoproteins and triglycerides in the settled population and in watchmen.

[Epidemiology and risk factors of cerebral stroke in Khanty-Mansiysk autonomic region: population register data].

Based on register data, epidemiologic indicators of cerebral stroke for the population of Khanty-Mansiysk autonomic okrug and values of early mortality and mean ages of patients have been obtained. The structure of acute disturbances of brain blood circulation has been studied. It has been shown that morbidity and mortality from cerebral stroke in the population of autonomic okrug is significantly lower compared to the same indicators in the Russian Federation in whole.

[Effects of hydrophilic and hydrophobic hydration in tetramethylbisurea and N,N'-dimethylpropyleneurea solutions].

The thermal effects of dissolving tetramethylbisurea in water at 298-318 K and N,N'-dimethylpropyleneurea at 293-313 K have been measured. It was shown that the standard heat of dissolution of tetramethylbisurea at 298 K was 3.58 +/- 0.

[A computer dermograph for localization diagnosis of focuses of internal organ diseases].

The principle of operation of DgKTD-01 dermographic hardware-software system for functional and localization diagnosis of internal organ diseases is described. The automated system can be used in restorative medicine departments and health centers for health state monitoring. The system can be effectively used by family physicians.

[Trans-meatal hyperbaric aerosol therapy some forms of otitis media chronica].

80 patients with otitis media chronica were effectively treated with hyperbaric aerosol. The aerosol therapy was performed with the help of a special device the design of which was based on that of made in Russia ultrasonic inhalator IUP-OIM intended for aerosol therapy of the upper respiratory tracts. The inhalator was furnished with a mini-compressor for pumping aerosol in the middle ear with maximal permissible pressure of hyperbaric aerosol delivery 10 kPa.

[Criteria of the evaluation of tubal function in patients with secretory otitis media].

Tubular function was assessed in patients with secretory otitis media before and after surgery (an original version of anterior tympanostomy). Preoperative tubular function was measured by impedance tympanometry. After tympanostoma was placed the acoustic tube was subjected to direct manometry.

[Clinico-audiological characteristics of secretory otitis media in children].

87 children aged 2-14 years with hypoacusis caused by secretory otitis media were examined and treated surgically. The diagnosis was made basing on the data obtained at otomicroscopy and tympanometry which in combination with tonal and speech hearing examinations provided quantitation and staging of the middle ear affection. It is suggested that morphologically and audiologically secretory otitis media undergoes four clinical stages: pre-exudative, primarily serous exudative, primarily mucous exudative, tympanosclerotic.