[Retrospective evaluation of blood immunologic parameters in the course of remission of acute lymphoblastic leukemia in children].

The authors investigated cellular and humoral immunity in 53 children over 3 years of age suffering from acute lymphoblastic leukemia. The children had remission lasting from 6 to 120 months and were followed up for 7-14 years after the diagnosis was made. The treatment was performed according to programs of polychemotherapy practiced in 1981-1988.

[Changes in the activity of endonucleolysis of nuclear DNA in children with acute leukemia].

The previously established fact of low activity of Ca, Mg-dependent endonucleolysis of cell nucleus DNA in lymphoproliferative diseases (CME-activity) brought the authors to study intranuclear characteristics of lymphoid cells in childhood acute lymphoblastic leukemia (ALL). The intensity of DNA-endonucleolysis was measured in 0.7% agarose gel using electrophoresis.

[Significance of different "tracing systems" in the assessment of remission and prerecurrence states in acute leukemia in children].

The authors provide the world reported data and materials of their own observations regarding the use of the "tracing systems" to control the residual pool of leukemic cells as a source of potential relapses. An attempt has been made to classify the techniques available; they are discussed from the stand point of the information content and feasibility in hematological practice. The necessity of developing studies into this problem in the USSR is emphasized.